Pacientes con enfermedad de Parkinson avanzada con y sin congelación de la marcha. Análisis comparativo de lesiones vasculares en resonancia magnética cerebral

Gallardo, María José; Cabello, J; Pastor, Catherine M.; Muñoz-Torrero, J.J.; Carrasco, S.; Ibáñez, R.; Vaamonde, J.

doi:10.1016/j.nrl.2013.02.014

Cited by 10 publications

(1 citation statement)

References 32 publications

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“…When FOG occurs early in PD, it always has a mild form, and early detection of FOG is an alarm signal that may cast doubt on a diagnosis of PD. [ 17 ] The prevalence of FOG is higher in older patients, many of whom have osteoporosis and other multisystem diseases. FOG is one of the major disabling symptoms of advanced PD, as severe FOG can lead to falls, pain, skin contusions, fractures, and activity limitations.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of freezing of gait with early Parkinson disease in Chinese patients

Zhang¹,

Yin

Ouyang

et al. 2016

Medicine

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Section: Discussionmentioning

confidence: 99%

A prospective study of freezing of gait with early Parkinson disease in Chinese patients

Zhang¹,

Yin

Ouyang

et al. 2016

Medicine

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Analysis of gait characteristics and related factors in patients with Parkinson's disease based on wearable devices

Tang,

Liao,

Yao

et al. 2024

Brain and Behavior

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BackgroundPostural instability and gait disorder dominant (PIGD) is one of the most common disabling symptoms of Parkinson's disease (PD), which seriously affects patients’ quality of life. Therefore, it is essential to identify PIGD and develop targeted interventions to reduce the risk of PIGD in PD patients.Aim:This study aimed to investigate the gait characteristics of PD patients based on wearable devices and to establish a predictive model for their related influencing factors.MethodsThe retrospective medical records of patients from January 2020 to September 2023 were collected, including 159 patients with PD (divided into PIGD [n = 73] and non‐PIGD [n = 86] groups) and 200 healthy patients (as the healthy control group). Information from social demographic data, a blood test, scale scores, gait analysis based on wearable devices, white matter lesions, and the Fazekas scale was extracted and analyzed.ResultsCompared with the healthy control group, the mean step length, mean rate, mean angular velocity, and step length were lower in the PD group, while the mean steps were higher in the turning test. The incidence of PIGD was 46% in PD patients, and PD patients with the non‐tremor onset mode were more likely to develop PIGD than those with the tremor onset mode. Compared to the non‐PIGD group, the PIGD group showed more serious gait problems in different experimental tasks and had a higher Hoehn and Yahr (H‐Y) stage, Hamilton Anxiety Scale (HAMA) score, Hamilton Depression Scale score, periventricular white matter (PVWM) score, deep white matter score, and Fazekas scale score, but they had lower hemoglobin levels, D‐dimer levels, Tinetti Balance scores, Tinetti Gait scores, Berg Balance Scale scores, and Mini‐Mental State Examination (MMSE) scores. Logistic regression analysis showed that the MMSE score was negatively correlated with the occurrence of PIGD, while the HAMA score, H‐Y stage, PVWM score, and non‐tremor form of onset were positively correlated with the occurrence of PIGDConclusionThe incidence of gait disorder in PD patients is higher than that in the normal population. Moreover, cognitive dysfunction, anxiety state, H‐Y stage, PVWM score, and the non‐tremor mode of onset can be considered independent risk factors for PIGD.

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White Matter Hyperintensities, Dopamine Loss, and Motor Deficits in De Novo Parkinson's Disease

et al. 2021

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A BS TRACT: Background: White matter hyperintensities, prevalent in patients with Parkinson's disease (PD), significantly affect parkinsonian motor symptoms. The objective of this study was to investigate the relationship between white matter hyperintensities and nigrostriatal dopamine depletion and their interaction or mediating effects on motor symptoms in patients with drug-naive early-stage PD. Methods: This cross-sectional study enrolled 501 patients with de novo PD who initially underwent [ 18 F] N-(3fluoropropyl)-2β-carbonethoxy-3β-(4-iodophenyl) nortropane positron emission tomography and brain magnetic resonance imaging scans between April 2009 and September 2015 in a tertiary-care university hospital. We quantified dopamine transporter availability in each striatal subregion and assessed the severity of periventricular and lobar white matter hyperintensities using the Scheltens scale. The relationship between white matter hyperintensities, dopamine transporter availability in the posterior putamen, and Unified Parkinson's Disease Rating Scale (UPDRS) motor scores was assessed using multivariate linear regression and mediation analyses.Results: Periventricular and frontal white matter hyperintensities were generally associated with dopamine transporter availability in striatal subregions after adjusting for age at symptom onset, sex, disease duration, and vascular risk factors. There was an interaction effect between periventricular white matter hyperintensities and dopamine transporter availability in the posterior putamen for the axial motor score. The effect of white matter hyperintensities on UPDRS total score and bradykinesia subscore was indirectly mediated by dopamine transporter availability in the posterior putamen, whereas the axial sub-score was directly affected by white matter hyperintensities. Conclusions: This study suggests that the detrimental effect of white matter hyperintensities on parkinsonian motor symptoms is more relevant and independent for axial motor impairments in the status of mildly decreased striatal dopamine transporter availability.

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Pacientes con enfermedad de Parkinson avanzada con y sin congelación de la marcha. Análisis comparativo de lesiones vasculares en resonancia magnética cerebral

Abstract: Vascular lesions may contribute to the onset or worsening of FOG in patients with PD. This study suggests that cerebral vascular disease should be considered in patients with FOG.

Cited by 10 publications

References 32 publications

A prospective study of freezing of gait with early Parkinson disease in Chinese patients

A prospective study of freezing of gait with early Parkinson disease in Chinese patients

Analysis of gait characteristics and related factors in patients with Parkinson's disease based on wearable devices

White Matter Hyperintensities, Dopamine Loss, and Motor Deficits in De Novo Parkinson's Disease

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