Pacientes con trastorno por uso de alcohol:  resultados iniciales de un registro multicéntrico en la Red de Trastornos Adictivos-RTA. Estudio CohRTA

Sanvisens, Arantza; Rivas, Inmaculada; Rubio, Gabriel; Gual, Antoni; Torrens, Marta; Short, Antoni; Álvarez, Francisco; Tor, Jordi; Farré, M.; Fonseca, Fernando Rodrı́guez de; Muga, Roberto

doi:10.20882/adicciones.931

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…While major depressive disorders and anxiety are the most prevalent psychopathological comorbid disorders in alcohol use population 8 – 10 , cocaine and cannabis abuse are the most common lifetime comorbid substance disorders associated to AUD 11 . Moreover, chronic alcohol consumption could modulate neurogenesis and produce distortions on the central nervous system causing neurocognitive impairment 12 , 13 .…”

Section: Introductionmentioning

confidence: 99%

Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients

García-Marchena

Pizarro

Pavón

et al. 2020

Sci Rep

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Lysophosphatidic acid (LPA) species are bioactive lipids participating in neurodevelopmental processes. The aim was to investigate whether the relevant species of LPA were associated with clinical features of alcohol addiction. A total of 55 abstinent alcohol use disorder (AUD) patients were compared with 34 age/sex/body mass index-matched controls. Concentrations of total LPA and 16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA species were quantified and correlated with neuroplasticity-associated growth factors including brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-2, and neurotrophin-3 (NT-3). AUD patients showed dysexecutive syndrome (22.4%) and memory impairment (32.6%). Total LPA, 16:0-LPA, 18:0-LPA and 18:1-LPA concentrations, were decreased in the AUD group compared to control group. Total LPA, 16:0-LPA, 18:2-LPA and 20:4-LPA concentrations were decreased in men compared to women. Frontal lobe functions correlated with plasma LPA species. Alcohol-cognitive impairments could be related with the deregulation of the LPA species, especially in 16:0-LPA, 18:1-LPA and 20:4-LPA. Concentrations of BDNF correlated with total LPA, 18:2-LPA and 20:4-LPA species. The relation between LPA species and BDNF is interesting in plasticity and neurogenesis functions, their involvement in AUD might serve as a biomarker of cognitive impairment.

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Section: Introductionmentioning

confidence: 99%

Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients

García-Marchena

Pizarro

Pavón

et al. 2020

Sci Rep

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“…A researcher chosen by the principal investigator of each center was responsible for collecting all the data and registering it in an online database that was specially designed for the CohRTA project (Coresoft Clínico, http://www.coresoft.es). More details of the protocol have been published elsewhere (Sanvisens et al., 2018).…”

Section: Methodsmentioning

confidence: 99%

Clinical features of individuals with laboratory values suggestive of advanced liver fibrosis when first treated for alcohol use disorder

Zuluaga,

Fuster,

Blanes

et al. 2024

Alcohol, Clinical and Experimental Research

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BackgroundEffective screening for alcohol‐associated liver disease is relevant in the context of chronic, excessive alcohol consumption. Patients with alcohol‐associated liver disease are often not diagnosed until their liver disease is decompensated. We analyzed the prevalence and associations of Fibrosis‐4 index (FIB‐4) values suggestive of advanced liver fibrosis in patients referred for their first treatment of alcohol use disorder (AUD).MethodsWe conducted a cross‐sectional, multicenter study of noncirrhotic individuals referred for their first AUD treatment between March 2013 and April 2021. We obtained sociodemographic data, substance use characteristics, and blood samples at admission. We considered a FIB‐4 value ≥2.67 suggestive of advanced liver fibrosis and used logistic regression analyses to identify features associated with this value.ResultsWe included 604 patients (67% male), with a median age at admission of 48 years [IQR: 41–56 years]. The median duration of regular alcohol consumption was 21 years [IQR: 18–30 years] and the median alcohol consumption was 105 standard drink units (SDU)/week [IQR: 63–160 SDU/week]. A FIB‐4 value ≥ 2.67 was present in 19.3% of cases. These patients reported more frequent binge drinking (75.4% vs. 66%, p = 0.05) than those with FIB‐4 values below 2.67. In multivariate analysis, a history of binge drinking (OR 1.9, 95% CI, 1.05–3.47), anemia (OR 2.95, 95% CI, 1.42–6.11), leukopenia (OR 7.46, 95% CI, 2.07–26.8), and total serum bilirubin >1 mg/dL (OR 6.46, 95% CI, 3.57–11.7) were independently associated with FIB‐4 values ≥2.67.ConclusionsOne in five patients admitted to treatment for AUD without evidence of decompensated liver disease have FIB‐4 values suggestive of advanced liver fibrosis. The presence of a binge drinking history, anemia, leukopenia, and elevated bilirubin levels is associated with high FIB‐4 values.

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“…This scientific network currently consists of 18 research groups from different regions of Spain and is dedicated to expanding academic knowledge about substance abuse, its origins, and consequences. Within the RTA framework, the first multicentre study of Spanish patients with AUD seeking treatment for the first time (CohRTA study) was carried out in 2013 (Sanvisens et al, 2017) and to date, has enrolled over 900 patients and has a biobank of associated biological samples. ■ IMMUNE SYSTEM: DISCREET DISORDERS The immune system is very complex and is key to host defence against pathogens; it comprises two components: innate and adaptive immunity (Szabo & Saha, 2015).…”

Section: «Alcohol Is the Most Widely Consumed Psychoactive Substance And Is Responsiblementioning

confidence: 99%

Las otras dianas del trastorno por uso de alcohol: Afectaciones sistémicas derivadas del consumo excesivo de alcohol

Sanvisens

Muga

2021

Metode SSJ

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Drinking alcohol is an established and normalised practice in our society, even though it can physically harm us. High-risk alcohol drinking patterns can increase the chance of negative consequences for the drinkers or their environment. The liver is by far the organ most affected by alcohol abuse; however, alcohol use disorder is a systemic disease which affects a wide range of organs and psychological processes. Other systems that can be affected by continued alcohol consumption include the immune, neurological, and cardiovascular systems. In addition, alcohol can lead to epigenetic alterations that may be transmitted from one generation to the next.

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Pacientes con trastorno por uso de alcohol: resultados iniciales de un registro multicéntrico en la Red de Trastornos Adictivos-RTA. Estudio CohRTA

Abstract: Resumen

Cited by 4 publications

References 26 publications

Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients

Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients

Clinical features of individuals with laboratory values suggestive of advanced liver fibrosis when first treated for alcohol use disorder

Las otras dianas del trastorno por uso de alcohol: Afectaciones sistémicas derivadas del consumo excesivo de alcohol

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