Pacing Lead-Induced Granuloma in the Atrium: A Foreign Body Reaction to Polyurethane

Shinagawa, Yoko; Kobayashi, Yuka; Iiri, Takao; Kitazawa, Hitoshi; Okabe, Masaru; Kobayashi, Hiroshi; Okazaki, Etsuo; Aizawa, Yoshifusa

doi:10.1155/2013/396595

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Rheumatic carditis is characterized by Aschoff nodules and MacCallum plaques (44). Granulomas have also been described as a reaction to a foreign body in patients with implanted permanent pacemaker (45).…”

Section: Histopathological Findings Potential Etiological Factors And...mentioning

confidence: 99%

Giant cell myocarditis in modern clinical practice

Lasica,

Đukanović,

Zdravković

et al. 2023

Medicinska istraživanja

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Giant cell myocarditis is a rare but extremely severe disease with a frequent need for heart transplantation and a high mortality rate. To this day, the most common reason for the occurrence of this disease has not been precisely determined, but its frequent association with autoimmune diseases speaks in favor of autoimmune etiology. Clinically, it is presented to the greatest extent by symptoms and signs of acute heart failure and ventricular rhythm disturbances, which are registered in as many as half of the patients. Arrhythmias can be accompanied by the occurrence of palpitations, repeated syncope, and even sudden cardiac death. A severe degree of acute heart failure in hemodynamically unstable patents who respond inadequately to the administered therapy for heart failure and refractory heart rhythm disorders and/or conduction disorders that are common in these patients should always raise suspicion of giant cell myocarditis. Given that changes in electrocardiogram, echocardiography and positive biomarker values are not strictly specific for this disease, the diagnosis of giant cell myocarditis is most often established by endomyocardial biopsy, especially in patients with the fulminant form of the disease. Timely endomyocardial biopsy enables not only quick and accurate diagnosis, but also early administration of immunosuppressive therapy, which greatly improves the outcome in these patients. Pathohistological verification of this disease is important so as to rule out cardiac sarcoidosis and other granulomatous infectious and non-infectious diseases. Given that in a large number of patients the disease has a fulminant course, early and rapid diagnosis, application of inotropic stimulation and mechanical circulatory support in hemodynamically unstable patients and adequate modern therapeutic regimen can largely reduce mortality in these patients, which is still high despite modern diagnostics and therapeutic progress of medicine.

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Section: Histopathological Findings Potential Etiological Factors And...mentioning

confidence: 99%

Giant cell myocarditis in modern clinical practice

Lasica,

Đukanović,

Zdravković

et al. 2023

Medicinska istraživanja

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“…The widespread utilization of medical devices has resulted in adverse FBR-related biological events [11]. The specific characteristics of the implant material play a crucial role in influencing FBRs, impacting the behavior of immune cells and the thickness of fibrous capsules formed around the implant.…”

Section: Introductionmentioning

confidence: 99%

Structural Features of Connective Tissue Formed around Resin Implants Subcutaneously Embedded in Dairy Cows

Katayama,

Ichii,

Nakamura

et al. 2023

Animals

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Foreign body reactions (FBRs) are inadvertently observed in invading or artificially embedded materials, triggering inflammation and subsequent fibrotic processes to occur in situ. Here, we assessed the spatiotemporal formation of connective tissue around implanted materials to establish a technique using connective tissue formed by FBRs as xenografts. An acrylic resin implant, comprising a columnar inner rod and a tubular outer cylinder (OC) with several slits, was embedded in adult dairy cows. Tissues formed in the inner rod and OC groups were histologically analyzed at weeks 2, 4, 8, and 12. Edematous tissues with non-collagenous fibers formed for 2 weeks and showed increased cellularity after 4 weeks. The weight, thickness, amounts of total protein, collagen, DNA, and quantitative scores of α-smooth muscle actin-positive myofibroblasts or elastic fibers notably increased after 8 weeks, with condensed collagen fibers showing orientation. Inflammatory cells were primarily localized in tissues close to the OC, and their numbers increased, with the count of CD204+ cells peaking at 8 weeks and declining at 12 weeks. The count of Ki67+ proliferating cells slightly increased in tissues close to the OC; however, the number and lumen of CD31+ vessels increased. These results may help understand FBR-related tissue remodeling.

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