Package of anti-allergic probiotic Lactobacillus by focusing on the regulatory role of immunosuppressive motifs in allergy

Mazhary, Zakie; Fard, Najaf Allahyari; Minuchehr, Zarrin; Javanshir, Nahid

doi:10.1016/j.imu.2019.100280

Cited by 11 publications

(5 citation statements)

References 30 publications

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“…However, some variants of CpG motifs and other microbial DNA sequences may have anti-inflammatory properties ( 78 , 79 ). This appears to be the case for many species of Lactobacillus ( 80 ) which could explain why the probiotic effects of lactobacilli depend on the presence of TLR9 in the gut ( 81 ).…”

Section: What Do Microbial Exposures Do For the Immune Systemmentioning

confidence: 97%

The old friends hypothesis: evolution, immunoregulation and essential microbial inputs

Rook

2023

Front. Allergy

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In wealthy urbanised societies there have been striking increases in chronic inflammatory disorders such as allergies, autoimmunity and inflammatory bowel diseases. There has also been an increase in the prevalence of individuals with systemically raised levels of inflammatory biomarkers correlating with increased risk of metabolic, cardiovascular and psychiatric problems. These changing disease patterns indicate a broad failure of the mechanisms that should stop the immune system from attacking harmless allergens, components of self or gut contents, and that should terminate inappropriate inflammation. The Old Friends Hypothesis postulates that this broad failure of immunoregulation is due to inadequate exposures to the microorganisms that drive development of the immune system, and drive the expansion of components such as regulatory T cells (Treg) that mediate immunoregulatory mechanisms. An evolutionary approach helps us to identify the organisms on which we are in a state of evolved dependence for this function (Old Friends). The bottom line is that most of the organisms that drive the regulatory arm of the immune system come from our mothers and family and from the natural environment (including animals) and many of these organisms are symbiotic components of a healthy microbiota. Lifestyle changes that are interrupting our exposure to these organisms can now be identified, and many are closely associated with low socioeconomic status (SES) in wealthy countries. These insights will facilitate the development of education, diets and urban planning that can correct the immunoregulatory deficit, while simultaneously reducing other contributory factors such as epithelial damage.

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Section: What Do Microbial Exposures Do For the Immune Systemmentioning

confidence: 97%

The old friends hypothesis: evolution, immunoregulation and essential microbial inputs

Rook

2023

Front. Allergy

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“…In the current study, the predicted IMs from BCRC 16100 did not display any Th1 cytokine induction capabilities and only IM5 in GM-080 exhibited IL-12 induction activity in mouse splenocytes (Table 2). Although the frequency of IMs in the genomes of probiotics may be associated with their antiallergic potential [43], the observed immunomodulatory activities of the predicted IMs warrant experimental examination. In the present study, we could not predict the relationship between the antiallergic activity of GM-080 and the associated changes in Th1 cytokine induction in vitro (Figure 2B,F) or the reduction in Th2 cytokine levels in vivo (Figure 5F).…”

Section: Discussionmentioning

confidence: 99%

Lacticaseibacillus paracasei GM-080 Ameliorates Allergic Airway Inflammation in Children with Allergic Rhinitis: From an Animal Model to a Double-Blind, Randomized, Placebo-Controlled Trial

Lin

Chang

Jhong

et al. 2023

Cells

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Background: Probiotics may facilitate the clinical management of allergic diseases. However, their effects on allergic rhinitis (AR) remain unclear. We examined the efficacy and safety of Lacticaseibacillus paracasei GM-080 in a mouse model of airway hyper-responsiveness (AHR) and in children with perennial AR (PAR) by using a double-blind, prospective, randomized, placebo-controlled design. Methods: The production of interferon (IFN)-γ and interleukin (IL)-12 was measured by using an enzyme-linked immunosorbent assay. GM-080 safety was evaluated via the whole-genome sequencing (WGS) of virulence genes. An ovalbumin (OVA)-induced AHR mouse model was constructed, and lung inflammation was evaluated by measuring the infiltrating leukocyte content of bronchoalveolar lavage fluid. A clinical trial was conducted with 122 children with PAR who were randomized to receive different doses of GM-080 or the placebo for 3 months, and their AHR symptom severity scores, total nasal symptom scores (TNSSs), and Investigator Global Assessment Scale scores were examined. Results: Among the tested L. paracasei strains, GM-080 induced the highest IFN-γ and IL-12 levels in mouse splenocytes. WGS analysis revealed the absence of virulence factors or antibiotic-resistance genes in GM-080. The oral administration of GM-080 at 1 × 107 colony forming units (CFU)/mouse/day for 8 weeks alleviated OVA-induced AHR and reduced airway inflammation in mice. In children with PAR, the oral consumption of GM-080 at 2 × 109 CFU/day for 3 months ameliorated sneezing and improved Investigator Global Assessment Scale scores significantly. GM-080 consumption led to a nonsignificant decrease in TNSS and also nonsignificantly reduced IgE but increased INF-γ levels. Conclusion: GM-080 may be used as a nutrient supplement to alleviate airway allergic inflammation.

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“…probiotics must consider the interactions these bacteria have on the amelioration of disease symptoms. The presence of immunosuppressive motifs across the genome sequences of probiotic species of Lactobacillus associated with reduced allergenicity have been identified and could serve as the basis for the selection of probiotic species to be utilized in treatment strategies ( 143 ). Additionally, previous investigations suggest prebiotic and probiotic supplementation to promote greater abundance of Prevotella spp.…”

Section: Therapeutic and Control Strategies For Allergic Diseasesmentioning

confidence: 99%

Immunologic, genetic, and ecological interplay of factors involved in allergic diseases

Falcon

Caoili

2023

Front. Allergy

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An allergic or type I hypersensitivity reaction involves a misdirected immune overreaction to innocuous environmental and dietary antigens called allergens. The genetic predisposition to allergic disease, referred to as atopy, can be expressed as a variety of manifestations—e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, allergic asthma, anaphylaxis. Globally, allergic diseases are one the most common types of chronic conditions. Several factors have been identified to contribute to the pathogenesis and progression of the disease, leading to distinctively variable clinical symptoms. The factors which can attenuate or exacerbate allergic reactions can range from genetic heterozygosity, the prominence of various comorbid infections, and other factors such as pollution, climate, and interactions with other organisms and organism-derived products, and the surrounding environment. As a result, the effective prevention and control of allergies remains to be one of the most prominent public health problems. Therefore, to contextualize the current knowledge about allergic reactions, this review paper attempts to synthesize different aspects of an allergic response to describe its significance in the global health scheme. Specifically, the review shall characterize the biomolecular mechanisms of the pathophysiology of the disease based on underlying disease theories and current findings on ecologic interactions and describe prevention and control strategies being utilized. An integrated perspective that considers the underlying genetic, immunologic, and ecologic aspects of the disease would enable the development of more effective and targeted diagnostic tools and therapeutic strategies for the management and control of allergic diseases.

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Package of anti-allergic probiotic Lactobacillus by focusing on the regulatory role of immunosuppressive motifs in allergy

Cited by 11 publications

References 30 publications

The old friends hypothesis: evolution, immunoregulation and essential microbial inputs

The old friends hypothesis: evolution, immunoregulation and essential microbial inputs

Lacticaseibacillus paracasei GM-080 Ameliorates Allergic Airway Inflammation in Children with Allergic Rhinitis: From an Animal Model to a Double-Blind, Randomized, Placebo-Controlled Trial

Immunologic, genetic, and ecological interplay of factors involved in allergic diseases

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