Packaging of Multiparticulate Dosage Forms

Murthy, K. S. Keshava; Reiterer, Franz; Wendt, Jürgen

doi:10.1201/b14855-16

Drugs and the Pharmaceutical Sciences

1994

DOI: 10.1201/b14855-16

|View full text |Cite

Packaging of Multiparticulate Dosage Forms

K. S. Keshava Murthy¹,

Franz Reiterer²,

Jürgen Wendt³

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2004

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Particle Size Distributions of Inert Spheres and Pelletized Pharmaceutical Products by Image Analysis

Heinicke¹,

Schwartz

2004

Pharmaceutical Development and Technology

View full text Add to dashboard Cite

Image analysis was used to measure particle size distributions (PSDs) of ensembles of 425 to 1400 microm-size materials. Repeatability of a measurement, suitable sample sizes, and methods of sampling were assessed. Two lots of inert spheres were compared prior to drug layering in a Glatt GPCG-5 rotor. The differences in PSD in the starting materials were reflected in the rotor-granulated products. Such detailed information was not available from sieving with U.S. standard wire mesh sieves. The products from the rotor process were polymer-coated in a Wurster process in a Glatt GPCG-3, 4-in. Wurster. The resolution of the technique was sufficient to measure differences in diameter equating to 4-microm coat thickness, which resulted from applying 2% polymer coat weight. The utility of the technique for monitoring commercial scale processes was demonstrated by measuring diameter after layering drug onto nonpareils in a Glatt RG-150 rotor, and by measuring the diameter after application of a polymer solution in a Glatt 46-in. Wurster coating process. The similarity of samples removed from the sample port in situ and samples from the batch suggested that processes in the fluid bed are intensively mixed and inherently random.

show abstract

Particle Size Distributions of Inert Spheres and Pelletized Pharmaceutical Products by Image Analysis

Heinicke¹,

Schwartz

2004

Pharmaceutical Development and Technology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Packaging of Multiparticulate Dosage Forms

Cited by 1 publication

References 14 publications

Particle Size Distributions of Inert Spheres and Pelletized Pharmaceutical Products by Image Analysis

Particle Size Distributions of Inert Spheres and Pelletized Pharmaceutical Products by Image Analysis

Contact Info

Product

Resources

About