Packing Density of Glycolipid Biosurfactant Monolayers Give a Significant Effect on Their Binding Affinity Toward Immunoglobulin G

Imura, Tomohiro; Masuda, Yoichi; Ito, Seya; Worakitkanchanakul, Wannasiri; Morita, Tomotake; Fukuoka, Tokuma; Sakai, Hideki; Abe, Masahiko; Kitamoto, Daï

doi:10.5650/jos.57.415

Cited by 17 publications

(9 citation statements)

References 28 publications

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“…These MELs exhibit not only excellent interfacial properties [12], but also remarkable differentiation‐inducing activities against human leukaemia cells [13,14], rat pheochromocytoma [15] and mouse melanoma cells [16,17]. MELs also show high binding affinity towards different immunoglobulins and lectins [18–23]. In addition, MEL‐A, the major component of MELs, dramatically increases the efficiency of gene transfection mediated by cationic liposomes [24–27].…”

Section: Melsmentioning

confidence: 99%

“…Previously Im et al [21] reported that MEL‐A shows high binding affinity towards human IgG. The binding behaviour was further investigated by using surface plasmon resonance and the measurement of surface pressure (π)–area ( A ) isotherms [23]. Three kinds of MEL‐A were prepared: MEL‐A (m) from methyl myristate, MEL‐A (o) from olive ( Olea europea ) oil and MEL‐A (s) from soybean oil.…”

Section: Binding Affinity Towards Immunoglobulins and Lectins Of Melmentioning

confidence: 99%

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Production of glycolipid biosurfactants by basidiomycetous yeasts

Morita

Fukuoka

Imura

et al. 2009

Biotech and App Biochem

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BSs (biosurfactants) produced by various micro-organisms show unique properties (e.g. mild production conditions, lower toxicity, higher biodegradability and environmental compatibility) compared with chemically synthesized surfactants. The numerous advantages of BSs have prompted applications not only in the food, cosmetic and pharmaceutical industries but also in environmental protection and energy-saving technology. Among BSs, glycolipid types are the most promising, owing to their high productivity from renewable resources and versatile biochemical properties. MELs (mannosylerythritol lipids), which are glycolipid BSs abundantly produced by basidiomycetous yeasts such as strains of Pseudozyma, exhibit not only excellent interfacial properties, but also remarkable differentiation-inducing activities against human leukaemia cells. MELs also show high binding affinity towards different immunoglobulins and lectins. Recently, a cationic liposome bearing MEL has been demonstrated to increase dramatically the efficiency of gene transfection into mammalian cells. These features of BSs should broaden their application in new advanced technologies. In the present review the current status of research and development on glycolipid BSs, especially their production by Pseudozyma yeasts, is described.

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Section: Melsmentioning

confidence: 99%

Section: Binding Affinity Towards Immunoglobulins and Lectins Of Melmentioning

confidence: 99%

Production of glycolipid biosurfactants by basidiomycetous yeasts

Morita

Fukuoka

Imura

et al. 2009

Biotech and App Biochem

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“…Surfactin is not ribosomally synthesized; it is synthesised by a multifunctional enzyme system as that involved in the synthesis of the peptide antibiotics released from bacilli bacteria [5]. Moreover, B. licheniformis has the ability to produce many surface active lipopeptides [7, 8]. …”

Section: Introductionmentioning

confidence: 99%

Enhancement ofBacillus subtilisLipopeptide Biosurfactants Production through Optimization of Medium Composition and Adequate Control of Aeration

Ghribi

Ellouze-Chaâbouni²

2011

Biotechnology Research International

134

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Interest in biosurfactants has increased considerably in recent years, as they are potentially used in many commercial applications in petroleum, pharmaceuticals, biomedical, and food processing industries. Since improvement of their production was of great importance to reduce the final coast, cultural conditions were analyzed to optimize biosurfactants production from Bacillus subtilis SPB1 strain. A high yield of biosurfactants was obtained from a culture of B. subtilis using carbohydrate substrate as a carbon source; among carbohydrates, glucose enhanced the best surfactin production. The optimum glucose concentration was 40 g/L. Higher amount of biosurfactants was obtained using 5 g/L of urea as organic nitrogen source and applying C/N ratio of 7 with ammonium chloride as inorganic nitrogen source. The highest amount of biosurfactants was recorded with the addition of 2% kerosene. Moreover, it was shown, using an automated full-controlled 2.6 L fermenter, that aeration of the medium, which affected strongly the growth regulated biosurfactants synthesis by the producing cell. So that, low or high aerations lead to a decrease of biosurfactants synthesis yields. It was found that when using dissolved oxygen saturation of the medium at 30%, biosurfactants production reached 4.92 g/L.

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“…Konishi et al, (2007), Imura et al, (2007Imura et al, ( , 2008, and Ito et al, (2007), for example, developed and studied the kinetics of interactions in carbohydrate ligand systems composed of self-assembled monolayers of mannosylerythritol lipid-A (MEL-A) serving as a high-affinity, easy to handle and low-cost ligand system for immunoglobulin G and M and lectins.. Table 1 below lists the latest discoveries in the biotechnological and nanotechnological fields applicable to biosurfactants, and in particular the latest successful results of mannosylerythritol lipids (MELs) application in the enhancement of the gene transfection efficiency of cationic liposomes as well as some interesting applications of glycolipids and other biosurfactants in drug delivery and gene therapy. Biosurfactants use as a "green" alternative for high-performance nanomaterials production and, in particular, for the synthesis and stabilization of metal-bound nanoparticles will also be described.…”

Section: Biotechnological and Nanotechnological Applications Of Surfamentioning

confidence: 99%

Biosurfactants and Bioemulsifiers Biomedical and Related Applications – Present Status and Future Potentials

Fracchia¹,

Cavallo²,

Martinotti³

et al. 2012

Biomedical Science, Engineering and Technology

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Packing Density of Glycolipid Biosurfactant Monolayers Give a Significant Effect on Their Binding Affinity Toward Immunoglobulin G

Abstract: Mannosylerythritol lipid-A (MEL-A

Cited by 17 publications

References 28 publications

Production of glycolipid biosurfactants by basidiomycetous yeasts

Production of glycolipid biosurfactants by basidiomycetous yeasts

Enhancement ofBacillus subtilisLipopeptide Biosurfactants Production through Optimization of Medium Composition and Adequate Control of Aeration

Biosurfactants and Bioemulsifiers Biomedical and Related Applications – Present Status and Future Potentials

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