Packing procedure effective for liver transplantation in hemophilic patients with HIV/HCV coinfection

Eguchi, Susumu; Soyama, Akihiko; Hara, Takanobu; Hidaka, Masaaki; Ono, Satoshi; Adachi, Tomohiko; Hamada, Takashi; Kugiyama, Tota; Ito, Sinichiro; Kanetaka, Kengo; Maekawa, Takuji; Sekino, Motohiro; Hara, Tetsuya; Nagai, Kazuhiro; Miyazaki, Yasushi

doi:10.1007/s00595-020-02051-1

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Recently, results of liver transplantation (LT) for patients with hemophilia have been published indicating that the complication rate-especially bleeding complications-was higher in hemophiliac patients, while overall survival rate was the same as that in patients without hemophilia. 18 For hemophilia patients, meticulous hemostasis and planning for bleeding control are very important for successful LT. [19][20][21] Including LT, all HPB surgeries were performed safely and mortality and post-operative morbidity were not conspicuous. The incidence and number of complications that occurred in this series, such as blood loss, complication rate, and mortality, were too small to analyze.…”

Section: Discussionmentioning

confidence: 99%

National survey of hepatobiliary and pancreatic surgery in hemophilia patients in Japan

Yoshimoto-Haramura

Hidaka

Hasegawa

et al. 2021

J Hepato Biliary Pancreat

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Background Approximately 8300 hemophiliacs are registered in Japan, but no comprehensive reports on hepatobiliary and pancreatic surgery (HBPS) have been conducted. This report investigates the current status of HPBS in hemophilia patients in Japan. Methods The subjects were hemophiliac patients seen between January 1 2007, and December 31 2017, at facilities participating in this study among the facilities for performing high‐difficulty cases nationwide designated by the Japanese Society for HBPS. A retrospective examination of short‐term outcomes in 49 cases was conducted to assess patient background, disease, surgical procedure, and complications. Results The types of hemophilia were A: 43 cases, B: four cases, and von Willebrand disease: two cases (hemophilia severity: mild 32, moderate seven, severe 10). The target malignant diseases for surgery were hepatocellular carcinoma (HCC) in 20 cases, intrahepatic cholangiocellular carcinoma (CCC) in four cases, combined HCC‐CCC in two cases, hilar CCC in two cases, and pancreatic cancer in four cases. As for the surgical procedure, limited resection (subsegmentectomy and partial hepatectomy) was performed in 16 cases of HCC even with normal liver function tests. Pancreaticoduodenectomy and distal pacreatectomy were performed for pancreatic cancers as in the standard procedure. Postoperative complications were postoperative bleeding in two cases after hepatectomy and one after pancreatectomy in one case. When compared with Japanese National Clinical Data base, the complication rates after hepatectomy and pancreatectomy were not conspicuous in hemophilic patients. Conclusions As long as they are performed in qualified centers, complication rate is not increased in hemophilic patients undergoing HBPS.

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Section: Discussionmentioning

confidence: 99%

National survey of hepatobiliary and pancreatic surgery in hemophilia patients in Japan

Yoshimoto-Haramura

Hidaka

Hasegawa

et al. 2021

J Hepato Biliary Pancreat

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“…In Japan, our study group advocated changes in the current order of priority for the deceased donor LT (DDLT) waiting list for patients co-infected with HIV/HCV, including an increase in priority for co-infected patients in 2013 and the establishment of a scoring system for DDLT registration corresponding to the Model for End-stage Liver Disease (MELD) in 2019. 14 Recently, the introduction of the use of the direct-acting antiviral agent (DAA) for HCV has been shown to eradicate HCV hepatitis and related liver cirrhosis, even in patients with HIV [15][16][17] after LT for HCV-related liver cirrhosis. Previously, our LT patients were reinfected with HCV and became cirrhotic within 5 years; however, after the introduction of DAA, our patients attained a better overall survival after LT.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the introduction of the use of the direct‐acting antiviral agent (DAA) for HCV has been shown to eradicate HCV hepatitis and related liver cirrhosis, even in patients with HIV 15–17 after LT for HCV‐related liver cirrhosis. Previously, our LT patients were re‐infected with HCV and became cirrhotic within 5 years; however, after the introduction of DAA, our patients attained a better overall survival after LT.…”

Section: Introductionmentioning

confidence: 99%

Impact of sustained viral response for hepatitis C virus on the outcomes of liver transplantation in hemophilic patients with human immunodeficiency virus/hepatitis C virus co‐infection: A nationwide survey in Japan

Hidaka

Eguchi

Hasegawa

et al. 2022

Hepatology Research

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Aim: Human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection from blood products for hemophilia has been a social problem in Japan, and liver transplantation (LT) for these patients has been a challenging procedure. However, with the advent of the direct-acting antiviral agent for HCV and change in the policy for prioritization of deceased donor LT, the results of LT for patients co-infected with HCV/HIV may have improved.Methods: This study was conducted to provide updated results of our nationwide survey of LT for patients co-infected with HCV/HIV, from January 1997 to December 2019. We collected data on 17 patients with HIV/HCV co-infection who underwent either deceased donor LT (n = 5) or living donor LT (n = 12).

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Recent advances in surgery and its perioperative treatment in people with hemophilia

Rodríguez-Merchán

2021

Expert Review of Hematology

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Packing procedure effective for liver transplantation in hemophilic patients with HIV/HCV coinfection

Cited by 3 publications

References 10 publications

National survey of hepatobiliary and pancreatic surgery in hemophilia patients in Japan

National survey of hepatobiliary and pancreatic surgery in hemophilia patients in Japan

Impact of sustained viral response for hepatitis C virus on the outcomes of liver transplantation in hemophilic patients with human immunodeficiency virus/hepatitis C virus co‐infection: A nationwide survey in Japan

Recent advances in surgery and its perioperative treatment in people with hemophilia

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