Paclitaxel alleviates the sepsis-induced acute kidney injury via lnc-MALAT1/miR-370-3p/HMGB1 axis

Xu, Lina; Hu, Gangfeng; Xing, Pengcheng; Zhou, Minjie; Wang, Donglian

doi:10.1016/j.lfs.2020.118505

Cited by 48 publications

(38 citation statements)

References 44 publications

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“…Interestingly, miR-150-5p show the same trend in circRNA-miRNA-mRNA network, suggesting that miR-150-5p may have a key role in the therapy of SLA through lncRNA/circRNA-miRNA-mRNA network. In addition, many researches revealed several miR-370-3p related ceRNA in sepsis progression, including lnc-MALAT1/miR-370-3p/HMGB1 [34], lnc-NEAT1/miR-370-3p/ Irak2 [35], lnc-NEAT1/miR-370-3p/TSP-1[36], which is consistent with our results of circRNA-miRNA-mRNA network. However, the mechanism of ncRNAs is complicated and we will further explore these predicted ceRNA mechanisms.…”

Section: Discussionsupporting

confidence: 89%

Whole Transcriptome Analysis on Sepsis Caused by Pyogenic Liver Abscess

Zhao¹,

Liu²,

Han³

et al. 2021

Preprint

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Background Pyogenic liver abscess (PLA) is a common clinical disease throughout the world with remaining high mortality and morbidity. This study sought to investigate key genes and non-coding RNAs (ncRNAs) associated with the pathogenesis and treatment of sepsis caused by PLA (SLA). Methods We constructed the expression profiles of RNAs by RNA sequencing in the peripheral blood of healthy subjects, SLA and seven day therapy of SLA patients. Then the sequencing data was analysed through integrated bioinformatics strategy. Results 4549 mRNAs, 9808 lncRNAs, 467 circRNAs and 292 miRNAs were differentially expressed (DE) between SLA and control samples. 3199 mRNAs, 6018 lncRNAs, 161 circRNAs and 132 miRNAs were differentially expressed between SLA after 7 days therapy and SLA control subjects. Moreover, DE mRNAs of the former two comparisons were both related to immunity and T cell-mediated immune response; DE lncRNAs were both associated with B cell receptor signaling pathway and Osteoclast differentiation; DE circRNAs were both related to Chagas disease and B cell receptor signaling pathway; DE miRNAs exerts its specific role in the process of SLA by MAPK signaling pathway and Estrogen signaling pathway compared to DE lncRNAs, circRNAs and mRNAs. Finally, lncRNA/circRNA–miRNA–mRNA network was constructed to explore the internal regulating relationships of these ncRNAs and mRNAs. Conclusions Our results may provide a new perspective on differential RNA expression involved in the pathogenesis and treatment of SLA and accelerate the development of novel treatments for this disease.

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Section: Discussionsupporting

confidence: 89%

Whole Transcriptome Analysis on Sepsis Caused by Pyogenic Liver Abscess

Zhao¹,

Liu²,

Han³

et al. 2021

Preprint

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“…Patients with sepsis undergo an inflammatory response driven by continuous or late HMGB1 release (Wei et al, 2019). Therefore, targeting HMGB1 may serve as a promising therapeutic strategy for sepsis-induced AKI (Xu et al, 2020). However, whether miR-106a-5p and HMGB1 are involved in circTLK1mediated AKI progression remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA TLK1 Promotes Sepsis-Associated Acute Kidney Injury by Regulating Inflammation and Oxidative Stress Through miR-106a-5p/HMGB1 Axis

Yang

2021

Front. Mol. Biosci.

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Sepsis is an inflammatory disorder and leads to severe acute kidney injury (AKI). Circular RNAs (circRNAs) have been identified as a critical type of regulatory noncoding RNAs (ncRNAs) that present the important functions in various diseases. In this study, we identified a novel circRNA circTLK1 in the regulation of sepsis-induced AKI. We observed that circTLK1 expression was elevated in the cecal ligation and puncture (CLP) rat model compared with that in the control rats. The urine levels of neutrophil gelatinase–associated lipocalin (NGAL) and kidney injury molecule-1 (Kim-1) and the serum levels of creatinine (sCr) and blood urea nitrogen (BUN) were increased by the CLP treatment in the rats but were blocked by the circTLK1 shRNA. The circTLK1 shRNA reduced the CLP-induced kidney injury in the rats. The circTLK1 knockdown repressed oxidation stress, inflammation, and apoptosis in the sepsis-related AKI rat model. Moreover, lipopolysaccharide (LPS) treatment increased the production of TNF-α, IL-1β, and IL-6 in the HK-2 cells, while the circTLK1 shRNA could attenuate the enhancement in the cells. Bax and cleaved caspase-3 expression was upregulated, but Bcl-2 expression was downregulated by the LPS in the HK-2 cells, in which circTLK1 depletion reversed this effect in the cells. The depletion of circTLK1 attenuated the LPS-induced apoptosis in the HK-2 cells. CircTLK1 enhanced HMGB1 expression by sponging miR-106a-5p in the HK-2 cells, and miR-106a-5p and HMGB1 were involved in circTLK1-meidated injury of LPS-treated cells. Therefore, we concluded that circTLK1 contributed to sepsis-associated AKI by regulating inflammation and oxidative stress through the miR-106a-5p/HMGB1 axis. CircTLK1 and miR-106a-5p may be employed as the potential targets for the treatment of AKI.

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“…Earlier studies have demonstrated that blocking strong expression of HMGB1 in inflammatory diseases, such as rheumatoid arthritis, myositis, and systemic lupus erythematosus can attenuate inflammation (24). Recent studies have found that targeting HMGB1 can reduce inflammatory response which in turn reduces sepsis associated organ damage (25)(26)(27)(28). Therefore, antagonizing HMGB1 in serum or intervening in the pathway of HMGB1 mediated proinflammatory pathways may facilitate development of potential therapies in sepsis.…”

Section: The Role Of Hmgb1 In Inflammationmentioning

confidence: 99%

The Regulatory Role of High-Mobility Group Protein 1 in Sepsis-Related Immunity

2021

Front. Immunol.

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High-mobility group box 1 (HMGB1), a prototypical damage-associated molecular pattern (DAMP) molecule, participates in multiple processes of various inflammatory diseases through binding to its corresponding receptors. In the early phase, sepsis is mainly characterized as a multi-bacterial-induced complex, excessive inflammatory response accompanied by the release of pro-inflammatory mediators, which subsequently develops into immune paralysis. A growing number of in vivo and in vitro investigations reveal that HMGB1 plays a pivotal role in the processes of inflammatory response and immunosuppression of sepsis. Therefore, HMGB1 exerts an indispensable role in the immune disorder and life-threatening inflammatory syndrome of sepsis. HMGB1 mainly mediate the release of inflammatory factors via acting on immune cells, pyroptosis pathways and phosphorylating nuclear factor-κB. Moreover HMGB1 is also associated with the process of sepsis-related immunosuppression. Neutrophil dysfunction mediated by HMGB1 is also an aspect of the immunosuppressive mechanism of sepsis. Myeloid-derived suppressor cells (MDSCs), which are also one of the important cells that play an immunosuppressive effect in sepsis, may connect with HMGB1. Thence, further understanding of HMGB1-associated pathogenesis of sepsis may assist in development of promising treatment strategies. This review mainly discusses current perspectives on the roles of HMGB1 in sepsis-related inflammation and immunosuppressive process and its related internal regulatory mechanisms.

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Paclitaxel alleviates the sepsis-induced acute kidney injury via lnc-MALAT1/miR-370-3p/HMGB1 axis

Cited by 48 publications

References 44 publications

Whole Transcriptome Analysis on Sepsis Caused by Pyogenic Liver Abscess

Whole Transcriptome Analysis on Sepsis Caused by Pyogenic Liver Abscess

Circular RNA TLK1 Promotes Sepsis-Associated Acute Kidney Injury by Regulating Inflammation and Oxidative Stress Through miR-106a-5p/HMGB1 Axis

The Regulatory Role of High-Mobility Group Protein 1 in Sepsis-Related Immunity

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