1999
DOI: 10.1002/(sici)1097-0142(19991201)86:11<2364::aid-cncr26>3.0.co;2-3
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Paclitaxel, cisplatin, and 5-fluorouracil for patients with advanced or recurrent squamous cell carcinoma of the head and neck

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Cited by 36 publications
(12 citation statements)
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References 11 publications
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“…Despite the administrative and toxicity profile complexity of the MVAC regimen, our response rate of 46% and 1‐year survival rate of 43% compares favorably with recent studies using paclitaxel/cisplatin/5‐fluorouracil and paclitaxel/ifosfamide/cisplatin regimens with 1‐year survival rates of 37% and 41%, respectively 20, 21. What is lacking in our study, as well as in other studies, are data on quality of life.…”
Section: Discussionsupporting
confidence: 65%
“…Despite the administrative and toxicity profile complexity of the MVAC regimen, our response rate of 46% and 1‐year survival rate of 43% compares favorably with recent studies using paclitaxel/cisplatin/5‐fluorouracil and paclitaxel/ifosfamide/cisplatin regimens with 1‐year survival rates of 37% and 41%, respectively 20, 21. What is lacking in our study, as well as in other studies, are data on quality of life.…”
Section: Discussionsupporting
confidence: 65%
“…The median number of cycles administered and the dose intensity achieved for all four study agents highlight the feasibility of this regimen (the primary objective of the current trial). For both cisplatin and paclitaxel, median dose intensities and median total doses were equivalent to those reported previously,11–17, 26 but the duration of treatment was significantly shorter in the current study.…”
Section: Discussionsupporting
confidence: 80%
“…The observed response rate and median OS, both of which were somewhat higher than those consistently reported in association with the standard cisplatin/5‐FU regimen in this setting, are noteworthy 5, 6. Compared with other paclitaxel‐containing combinations, the current regimen was equally active in the induction setting15–17 but had a higher level of activity in patients with recurrent disease 11–14. This finding also holds true for the comparison of the study regimen with docetaxel‐containing regimens 24, 25.…”
Section: Discussionsupporting
confidence: 50%
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“…Depending on the patient population treated, response rates ranged from 40 to 60%, with moderate response duration in some patients [28][29][30][31][32]40,41]. Depending on the patient population treated, response rates ranged from 40 to 60%, with moderate response duration in some patients [28][29][30][31][32]40,41].…”
Section: Taxanes In Combination With Other Chemotherapy Agentsmentioning
confidence: 99%