2012
DOI: 10.1161/circinterventions.112.969972
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Paclitaxel-Coated Versus Uncoated Balloon Angioplasty Reduces Target Lesion Revascularization in Patients With Femoropopliteal Arterial Disease

Abstract: Background-In disease of the femoropopliteal artery, paclitaxel-coated balloon (PCB) therapy improved angiographic outcomes as compared with uncoated balloon (UCB) angioplasty. Nevertheless, it remains uncertain whether PCB may reduce the need for reintervention. Methods and Results-We searched Medline, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), scientific session abstracts, and relevant web sites for trials of PCB versus UCB angioplasty. Key words were: "superficial femoral artery,"… Show more

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Cited by 114 publications
(58 citation statements)
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“…Most of current DES platforms slowly release cytostatic sirolimus or cytotoxic paclitaxel [9,43]. DCB are balloon catheters that are engineered for acute release of cytotoxic paclitaxel upon immediate contact with the vessel wall using an appropriate excipient, i.e., a drug carrier (contrast, urea, sorbitol) [7]. Stent-grafts consist of a stent platform covered with fabric (Dacron) or polytetrafluoroethylene (PTFE) that act as a barrier against NIH that encroaches the vessel lumen [44].…”
Section: Equipment Specificationsmentioning
confidence: 99%
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“…Most of current DES platforms slowly release cytostatic sirolimus or cytotoxic paclitaxel [9,43]. DCB are balloon catheters that are engineered for acute release of cytotoxic paclitaxel upon immediate contact with the vessel wall using an appropriate excipient, i.e., a drug carrier (contrast, urea, sorbitol) [7]. Stent-grafts consist of a stent platform covered with fabric (Dacron) or polytetrafluoroethylene (PTFE) that act as a barrier against NIH that encroaches the vessel lumen [44].…”
Section: Equipment Specificationsmentioning
confidence: 99%
“…Animal studies have provided strong proof of concept and several multicentre, randomized, controlled trials have shown a discernible difference in respect to vessel restenosis with all three strategies compared with standard old balloon angioplasty as described later [7][8][9][10]63]. On the other hand, laser and directional atherectomy have no proven benefit compared with standard balloon angioplasty and stenting [64,65].…”
Section: Procedural Featuresmentioning
confidence: 99%
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“…While duration of contact with the vessel wall (balloon delivery) may be brief (1-3 minutes), the effect of retained drug continues over several weeks [13]. Efficacy and better outcome measures following the use of drug covered balloons (DCBs) were proven when compared to plain balloon PTA [14,15]. Currently, DESs have been successfully shown to treat longer 2 Journal of Angiology and difficult CTO lesions in femoropopliteal disease as demonstrated in few concluded and current trials [16,17].…”
Section: Introductionmentioning
confidence: 99%