Paclitaxel/gelatin coated magnetic mesoporous silica nanoparticles: Preparation and antitumor efficacy in vivo

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

“…Target molecules allow the MSNs to reach the tumor tissue only through a molecular recognition mechanism. Then, once in the internal tissue, the stimuliresponsive capping agent [5,34] permits the release of the drug as a response to internal (change of pH [42][43][44][45], temperature [46][47][48], redox reactions [40,[49][50][51][52]) or external (irradiation with light [53][54][55], magnetic field [55][56][57]) stimuli.…”

Controllably Switched Drug Release from Successively Dual‐Targeted Nanoreservoirs

“…When pH of the solution continuously decreased to 5.0 without GSH treatment, the release amounts for the cross‐linked nanoparticles was only 20.9%, but for the uncross‐linked nanoparticles, it reached to 42.9%. This releasing discrepancy under different pH values can be ascribed to the cross‐linked structure, which leads to a compact structure of the MMSN coating layer, and restrains the mobility of the polymer segment, which would further hinder the penetration of the outside liquid to wet the drug molecules and prevent DOX from diffusion to the solution, thus endowing the cross‐linked nanoparticles good stability during the blood circulation. Interestingly, the release profiles of the cross‐linked MMSN‐S 2 ‐PEI‐PEG‐PBA kept the same as the uncross‐linked one in the presence of 10 × 10 −3 m GSH at pHs 7.4 and 5.0 during 24 h, respectively, which proved the redox‐triggered ability.…”

“…The peaks at 2924 and 2852 cm −1 were attributed to the asymmetrical stretching vibration and symmetrical stretching vibration of CH bonds in the methylene (CH 2 ) of cetyltrimethylammonium bromide (CTAB), respectively (Figure S5A, Supporting Information). In this system, CTAB is not only used as the organic template for the mesopores, but as the surfactant to stabilize Fe 3 O 4 in aqueous solution . After extracting the template, these peaks disappeared, indicating the formation of mesoporous structure (Figure S5B, Supporting Information).…”

“…To evaluate the crystallinity of the magnetic mesoporous silica nanoparticles, wide‐angle X‐ray diffraction (WAXRD) was conducted in Figure D. The broad band at 2θ = 23° is derived from the amorphous mesoporous silica nanoparticles, and the characteristic peaks at (220), (311), (400), (511), and (440) are typical of a spinel magnetite structure . The saturation magnetization was also characterized by vibrating sample magnetometer (VSM).…”

“…Actually, many efforts have been devoted to integrate magnetic nanoparticles with mesoporous silica nanoparticles for various bioapplications . In an attempt to exploit magnetic targeting to increase the enrichment of nanoreservoirs around the tumor site, many researches have focused on the superparamagnetic iron oxide nanoparticles due to their good biocompatibility . What is more, the magnetic mesoporous silica nanoparticles (MMSNs) could prevent iron leaching in acidic biological environment and provide good physical stability to magnetic nanoparticles.…”