2012
DOI: 10.2147/ijn.s34381
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Paclitaxel-loaded iron platinum stealth immunomicelles are potent MRI imaging agents that prevent prostate cancer growth in a PSMA-dependent manner

Abstract: Background and methods:Problems with the clinical management of prostate cancer include the lack of both specific detection and efficient therapeutic intervention. We report the encapsulation of superparamagnetic iron platinum nanoparticles (SIPPs) and paclitaxel in a mixture of polyethyleneglycolated, fluorescent, and biotin-functionalized phospholipids to create multifunctional SIPP-PTX micelles (SPMs) that were conjugated to an antibody against prostate-specific membrane antigen (PSMA) for the specific targ… Show more

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Cited by 46 publications
(41 citation statements)
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“…Our long history of applications of NMR to prostate cancer diagnosis 2,25,26,[33][34][35][36][37] suggested that we turn to this area for a candidate cell-surface epitope to discriminate between cancer cells and normal, non-malignant cells. Research on prostate cancer-specific cell markers 25,[27][28][29] led to the identification of PSMA, the folate receptor, as a cell-surface protein that is highly-overexpressed on prostate tumors.…”
Section: Specific Binding Of Anti-psma-conjugated Spions To Psma-posimentioning
confidence: 99%
See 1 more Smart Citation
“…Our long history of applications of NMR to prostate cancer diagnosis 2,25,26,[33][34][35][36][37] suggested that we turn to this area for a candidate cell-surface epitope to discriminate between cancer cells and normal, non-malignant cells. Research on prostate cancer-specific cell markers 25,[27][28][29] led to the identification of PSMA, the folate receptor, as a cell-surface protein that is highly-overexpressed on prostate tumors.…”
Section: Specific Binding Of Anti-psma-conjugated Spions To Psma-posimentioning
confidence: 99%
“…Such SPIONs loaded with therapeutic molecules, such as drugs, 2 microRNAs, 3 or shRNA, 4 are useful both as diagnostic and therapeutic agents, and an important, open question is how to accurately determine their concentrations in the target tissues in vivo, in a non-invasive manner. The direct methods that have been applied to SPION quantitation include both nonmagnetic schemes, such as positron emission tomography-computed tomography 5,6 and those utilizing the magnetic properties of the SPIONs, which include SQUID studies.…”
Section: Introductionmentioning
confidence: 99%
“…7 The ethylene oxide-propylene oxide (EO-PO) triblock copolymers have been extensively investigated. P105 is a PEO 37 -PPO 56 -PEO 37 triblock copolymer with a molecular weight of 6,500 Da and the potent ability to sensitize multidrug-resistant tumors and the capacity to encapsulate hydrophobic drugs. 8,9 OA-loaded P105/TPGS mixed micelles (OA-micelles) were prepared using a thin-film hydration method and possessed the aforementioned advantages.…”
Section: Wu Et Almentioning
confidence: 99%
“…Rapid release of water-soluble drugs may induce drug precipitation or their binding to plasma proteins in vivo, effectively resulting in drug dilution and possibly leading to drug inactivation. 37 Therefore, the slower release of OA from micelles can be an advantage for the antitumor effect of OA in vivo.…”
Section: Preparation and Characterization Of The Oa-micellesmentioning
confidence: 99%
“…On the other hand, nanotechnology is also being employed for diagnostic development. 101,103 The rationale for the employment of diagnostics development is to achieve a higher accuracy of diagnosis. Improvements in the sensitivity and specificity of nanotechnology are warranted and promising.…”
mentioning
confidence: 99%