Paclitaxel-loaded Pluronic nanoparticles formed by a temperature-induced phase transition for cancer therapy

Oh, Keun Sang; J, Song; Cho, Sun Hang; Lee, Bum Suk; Kim, Sang Yoon; Kim, Kwangmeyung; Jeon, Hyesung; Kwon, Ick Chan; Yuk, Soon Hong

doi:10.1016/j.jconrel.2010.08.021

Cited by 73 publications

(48 citation statements)

References 31 publications

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“…In an approach for improving the traditional paclitaxel formulation in Cremophor EL, Oh and collaborators, included paclitaxel in nanoparticles generated by a temperature-induced phase transition, with a mixture of Pluronic F-68 and liquid PEG, being this process solvent free [457].…”

Section: Paclitaxel Encapsulationmentioning

confidence: 99%

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Pérez-Herrero

Fernández‐Medarde

2015

European Journal of Pharmaceutics and Biopharmaceutics

1,466

754

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Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases. It is characterized by uncontrolled cell proliferation and an absence of cell death that, except for hematological cancers, generates an abnormal cell mass or tumor. This primary tumor grows thanks to new vasculatization and, in time, adquires metastatic potential and spreads to other body sites, which causes metastasis and finally death. Cancer is caused by damage or mutations in the genetic material of the cells due to environmental or inherited factors. While surgery and radiotherapy are the primary treatment used for local and non-metastatic cancers, anti-cancer drugs (chemotherapy, hormone and biological therapies) are the choice currently used in metastasic cancers. Chemotherapy is based on the inhibition of the division of rapidly growing cells, which is a characteristic of the cancerous cells, but unfortunately, it also affects normal cells with fast proliferation rates, like the hair follicles, bone marrow and gastrointestinal tract cells, generating the characteristic side effects of chemotherapy. The indiscriminate destruction of normal cells, the toxicity of conventional chemotherapeutic Código de campo cambiado

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Section: Paclitaxel Encapsulationmentioning

confidence: 99%

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Pérez-Herrero

Fernández‐Medarde

2015

European Journal of Pharmaceutics and Biopharmaceutics

1,466

754

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“…Temperature-induced phase transitions were reported for Pluronic/PLGA and Pluronic/PEO mixtures, where Pluronic is a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer and PEO stands for poly(ethylene oxide) [15,16]. The polymer mixtures formed a homogeneous phase upon heating above the melting temperature.…”

Section: Discussionmentioning

confidence: 99%

Paclitaxel-loaded poly(lactide-co-glycolide)/poly(ethylene vinyl acetate) composite for stent coating by ultrasonic atomizing spray

Yuk

Park

et al. 2012

Science and Technology of Advanced Materials

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The mixture of poly(lactide-co-glycolide) (PLGA) and poly(ethylene vinyl acetate) (PEVA) forms a homogeneous liquid in an organic solvent such as tetrahydrofuran, and a phase-separated PLGA/PEVA composite can be prepared from it by evaporating the organic solvent. Exploiting this phenomenon, we designed a novel method of preparing a drug-loaded PLGA/PEVA composite and used it for coating drug-eluting stents (DESs). Paclitaxel (PTX), an anticancer drug, was chosen as a model drug. PLGA acts as a microdepot for PTX, and PEVA provides mechanical strength to the coating material. The presence of PLGA in the PLGA/PEVA composite suppressed PTX crystallization in the coating material, and PTX showed a sustained release rate over more than 30 days. The mechanical strength of the PLGA/PEVA composite was better than that of PEVA used as a control. After coating the stent with a PLGA/PEVA composite using ultrasonic atomizing spray, the morphology of the coated material was observed by scanning electron microscopy, and the release pattern of PTX was measured by high-performance liquid chromatography.

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“…Phospholipids in combination with aqueous solvent or hydrophilic polymers, as PEG, were used as a matrix for incorporation of paclitaxel molecules [41]. The particles formed had an average size of 1000 nm.…”

Section: Complexes Of Paclitaxelmentioning

confidence: 99%

Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability

et al. 2011

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AbstractPaclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.

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Paclitaxel-loaded Pluronic nanoparticles formed by a temperature-induced phase transition for cancer therapy

Cited by 73 publications

References 31 publications

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Paclitaxel-loaded poly(lactide-co-glycolide)/poly(ethylene vinyl acetate) composite for stent coating by ultrasonic atomizing spray

Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability

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