Paclitaxel treatment reduces neointimal hyperplasia in cultured human saphenous veins☆

Schachner, Thomas; Steger, Christina; Heiss, Simone; Bonaros, Nikolaos; Sterlacci, William; Laufer, Guenther; Bonatti, Johannes

doi:10.1016/j.ejcts.2007.09.015

Cited by 14 publications

(8 citation statements)

References 22 publications

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“…Despite all expectations and our previously published results concerning human vein culture [17], the cultured pig vein segments showed no intimal hyperplasia, even though the vein culture method, components of the culture medium and the culture conditions were exactly the same. These findings are in contrast to Murphy et al [18], who noticed neointima formation in cultured porcine saphenous veins with significant reduction after paclitaxel treatment.…”

Section: Discussioncontrasting

confidence: 77%

“…For instance, we found a constant amount of elastic fibers in the wall of human saphenous veins, contrary to porcine internal mammary veins with increased percentage in the media of all vein segments. Moreover, human saphenous veins showed a double configured media, each consisting of a longitudinal and a circumferential part [17], in contrast to the media of porcine internal mammary veins (native, cultured and after CAGB), which consist of a single layer of circularly deployed vascular smooth muscle cells. All these microscopic findings may also play a role on molecular levels and lead to a different hemostasis of human and animal vessels, raising the question, in how far are animal models and organ culture models matchable to human conditions?…”

Section: Discussionmentioning

confidence: 90%

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Neointimal hyperplasia in a porcine model of vein graft disease: comparison between organ culture and coronary artery bypass grafting

Bonatti

Nagiller

et al. 2011

Eur Surg

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Background: Neointima formation is a crucial problem in the early phase after coronary artery bypass grafting which may result in vein graft stenosis and occlusion 10 years after surgery.Methods: Six pigs underwent aortocoronary bypass surgery by grafting the left internal mammary vein to the left anterior descending coronary artery (LAD). The remnants of internal mammary veins were cultured for 14 days under standardized conditions. Pigs were sacrificed two weeks after surgery. Histological and immunohistological investigations were performed with special regard to morphometric analysis, differences of the vein wall structure and connective tissue changes.Results: Histological examination revealed similar amounts of collagen, elastic and reticulin fibers in intima and media of native and cultured vein segments with an accumulation in the neointima of vessel specimens after bypass surgery (p < 0.01). Moreover, veins at day 14 after bypass surgery showed a significant increase of the intima (220.74 mm vs. 1.91 mm in native and 2.14 mm in cultured veins; p < 0.01) and a thickening of the media (334.07 mm vs. 52.44 mm in native and 76.29 mm in cultured veins; p < 0.01).Conclusions: Contrary to cultured vessel specimens, venous conduits are characterized by the development of neointima formation, thickening of the media and a higher percentage of elastic, collagen, reticulin fibers and vascular smooth muscle cells in the intima.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 90%

Neointimal hyperplasia in a porcine model of vein graft disease: comparison between organ culture and coronary artery bypass grafting

Bonatti

Nagiller

et al. 2011

Eur Surg

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“…Antiproliferative agents, such as the highly lipophilic microtubular stabilizer paclitaxel, prevent neointimal hyperplasia by inhibiting migration and cell division (figure 1). 11 A recent retrospective study of 19 patients with symptomatic ICAD showed promising results for a paclitaxel-coated DCB compared with the Wingspan stent system, with a lower recurrence rate 12…”

Section: Introductionmentioning

confidence: 99%

Percutaneous transluminal angioplasty using the novel drug-coated balloon catheter SeQuent Please NEO for the treatment of symptomatic intracranial severe stenosis: feasibility and safety study

Gruber

Braun

Kahles

et al. 2018

J NeuroIntervent Surg

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ObjectivesIntracranial arteriosclerotic disease is a relevant cause of ischemic stroke worldwide with a high recurrence rate despite best medical treatment. Following the SAMMPRIS trial, endovascular treatment has remained a second-line therapy. Meanwhile, there has been significant advances in device technology. SeQuent Please NEO is a novel polymer-free, drug-coated (paclitaxel/iopromide) balloon (DCB) primarily designed for cardiology. Because of its high flexibility and pushability, it may also be suitable for intracranial use. The aim of this study was to assess the feasibility and safety of SeQuent Please NEO DCB in symptomatic intracranial severe stenosis.MethodsA single-center retrospective cohort study of patients with symptomatic intracranial severe stenosis treated with SeQuent Please NEO DCB was performed at a tertiary stroke center.ResultsTen patients (all men, median age 73 years (IQR 69–77)) were included. Median pre-treatment stenosis grade was 78% (IQR 75–80%) with four internal carotid artery, two mid-basilar artery, and four vertebral artery lesions. Median post-treatment stenosis grade was 50% (IQR 45–53%). Successful angioplasty was achieved in all cases without technical failure. There were no cases of peri-procedural reocclusion and no deaths at median follow-up of 3 months (IQR 2–3).ConclusionIn this pilot study, SeQuent Please NEO DCB was feasible and safe in the treatment of symptomatic intracranial severe stenosis. It might represent a promising alternative to medical treatment in selected cases.

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“…Paclitaxel is a potent antiproliferative agent that prevents ISR by inhibiting cell division and migration for weeks and even months, by formation of abnormally stable microtubules. 23 The physical-chemical properties of the fixation allow only minimal amounts of the drug to be washed away by the blood stream during the insertion of the balloon into the stenotic vessel segment. The drug itself is brought in close contact with the luminal surface of the vessel intima by prolonged balloon inflation for 60 seconds with approximately 16% of the substance being taken up by the adjacent intima during this period.…”

Section: Discussionmentioning

confidence: 99%

Neurovascular In-Stent Stenoses: Treatment with Conventional and Drug-Eluting Balloons

Vajda

Güthe

Pérez

et al. 2011

AJNR Am J Neuroradiol

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Paclitaxel treatment reduces neointimal hyperplasia in cultured human saphenous veins☆

Cited by 14 publications

References 22 publications

Neointimal hyperplasia in a porcine model of vein graft disease: comparison between organ culture and coronary artery bypass grafting

Neointimal hyperplasia in a porcine model of vein graft disease: comparison between organ culture and coronary artery bypass grafting

Percutaneous transluminal angioplasty using the novel drug-coated balloon catheter SeQuent Please NEO for the treatment of symptomatic intracranial severe stenosis: feasibility and safety study

Neurovascular In-Stent Stenoses: Treatment with Conventional and Drug-Eluting Balloons

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