Paecilomyces variotii fungemia in a patient with multiple myeloma: case report and literature review

Salle, Valery; Lecuyer, E.; Chouaki, Taïeb; Lescure, François Xavier; Смаил, А.; Vaidie, A.; Dayen, C.; Schmit, J. L.; Ducroix, J.-P.; Douadi, Y.

doi:10.1016/j.jinf.2004.09.006

Cited by 29 publications

(20 citation statements)

References 18 publications

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“…However, small-subunit ribosomal gene sequences showed that the two species are unrelated: P. variotii belongs to the order Eurotiales, while P. lilacinus is a member of the order Hypocreales (27). Although they are uncommon, Paecilomyces infections are associated with almost any organ or system of the human body (40). Most cases concern immunocompromised patients and are cutaneous or catheter related.…”

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“…However, dissemination, for example, that involving the central nervous system, has been observed in a number of cases (15,24). Ocular infections associated with prolonged contact lens use or ocular surgery have also been reported (40), as has peritonitis in patients with continuous ambulatory peritoneal dialysis (24), which apparently responded well to antifungal therapy, with cures occurring in 11 of the 13 cases.…”

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Identification ofPaecilomyces variotiiin Clinical Samples and Settings

et al. 2010

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Paecilomyces variotii is a commonly occurring species in air and food, but it is also associated with many types of human infections and is among the emerging causative agents of opportunistic mycoses in immunocompromised hosts. Paecilomyces can cause hyalohyphomycosis, and two species, Paecilomyces lilacinus and P. variotii, are the most frequently encountered organisms. In the present study, a set of 34 clinical isolates morphologically identified as P. variotii or P. lilacinus were formally identified by sequencing intergenic transcribed spacer regions 1 and 2 (including 5.8S rDNA) and a part of the ␤-tubulin gene. Three isolates were identified as P. lilacinus, and five of the presumptive P. variotii isolates did not belong to the genus Paecilomyces but were identified as Talaromyces eburneus (anamorph, Geosmithia argillacea) or Hamigera avellanea (anamorph, Merimbla ingelheimense). Applying the most recent taxonomy, we found that the clinical P. variotii isolates could be identified as P. variotii sensu stricto (14 strains), P. formosus (11 strains), and P. dactylethromorphus (1 strain). These data indicate that P. formosus occurs in clinical samples as commonly as P. variotii. Susceptibility tests showed that the antifungal susceptibility profiles of P. variotii, P. formosus, and P. dactylethromorphus are similar and that all strains tested were susceptible to amphotericin B in vitro. P. lilanicus, T. eburneus, and H. avellanea had different susceptibility profiles; and flucytosine and voriconazole were the least active of the antifungal drugs tested against these species. Our results indicate that correct species identification is important to help guide appropriate antifungal therapy.Paecilomyces variotii is a commonly occurring species that has previously been isolated from various substrates, including (pasteurized) foods, soil, indoor air, and wood (23,36,41,42,43). However, it is also associated with many types of human infections and is listed among the emerging causative agents of opportunistic mycoses in immunocompromised hosts. Paecilomyces can cause hyalohyphomycosis (1), and two species, Paecilomyces lilacinus and P. variotii, are the most frequently encountered (20, 52). Both species are morphologically similar but can be differentiated on the basis of conidial color and growth rates (41). However, small-subunit ribosomal gene sequences showed that the two species are unrelated: P. variotii belongs to the order Eurotiales, while P. lilacinus is a member of the order Hypocreales (27). Although they are uncommon, Paecilomyces infections are associated with almost any organ or system of the human body (40). Most cases concern immunocompromised patients and are cutaneous or catheter related. However, dissemination, for example, that involving the central nervous system, has been observed in a number of cases (15,24). Ocular infections associated with prolonged contact lens use or ocular surgery have also been reported (40), as has peritonitis in patients with continuous ambulatory peritoneal dialy...

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Identification ofPaecilomyces variotiiin Clinical Samples and Settings

et al. 2010

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“…Paecilomyces varitii observed in the guano of R. hardwickii was reported in earlier studies in the substrate including pasteurized food, soil, indoor air and wood (Samson 1974;Pitt et al, 2009). Paecilomyces is listed among the emerging causative agents of opportunistic mycoses in immune compromised hosts, cutaneous or catheter related associated with almost any organ or system of the human body (Salle et al, 2005) and it causes hyalohyphomycosis (Ajello, 1986). The occurrence of Malbranchea sp.…”

Section: Discussionmentioning

confidence: 84%

Guanophilic Fungi of Mouse-Tailed Bats

Misra¹

2015

S. Asian J. Life Sci.

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| Bats utilize a wide range of structures as their roosting sites and occupy various food niches. The guanophilic fungi of insectivorous bats such as Rhinopoma hardwickii and R. microphyllum were isolated and identified morphologically using phase contrast and scanning electron microscopes. The fungal culture was carried out using potato dextrose agar (PDA) and species such as Aspergillus versicolar gr., A. flavus, A. niger, Aspergillus sp., Penicillium funiculosum, Penicillium sp., Absidia corymbifera, Cladosporium cladosporiodes, C. resinae, Chrysosporium tropicum, Paecilomyces varitii, Malbranchea sp., Trichoderma sp., Mucor sp. and yeast were isolated and characterized. Chrysosporium tropicum plays a vital role in degrading the insectivorous bat guano which has rich contents of keratin, while C. resinae decomposes the hydrocarbons available in the guano. Many other fungi isolated in this study are opportunistic and some are medically and environmentally important.

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“…Paecilomyces spp. infections have been rarely reported in dogs, 4–9 cats, 10,11 humans 12–18 and other animals 10 . Paecilomyces variotii and Paecilomyces lilacinus are responsible for most human and animal hyalohyphomycosis infections 19 .…”

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Generalized calcinosis cutis associated with disseminated paecilomycosis in a dog

Holahan¹,

Loft

Swenson

et al. 2008

Veterinary Dermatology

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A 4-year-old spayed female mixed breed dog was referred to the Michigan State University, Veterinary Teaching Hospital (MSU-VTH) with vomiting, lethargy and anorexia of 2 weeks duration. Abdominal radiographs and ultrasonography showed hepatosplenomegaly. Cytological evaluation of ultrasound-guided fine needle aspirates of the liver and spleen revealed fungal organisms and pyogranulomatous inflammation; fungal culture documented Paecilomyces variotii infection. The dog received antifungal therapy and supportive care. Multiple firm plaque-like skin lesions, predominantly involving the inguinal region, developed 18 days after initial presentation and were diagnosed histopathologically as calcinosis cutis. While generalized calcinosis cutis has been reported in three dogs with blastomycosis and one dog with leptospirosis, the association with disseminated Paecilomyces spp. infection is novel.

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Paecilomyces variotii fungemia in a patient with multiple myeloma: case report and literature review

Cited by 29 publications

References 18 publications

Identification ofPaecilomyces variotiiin Clinical Samples and Settings

Identification ofPaecilomyces variotiiin Clinical Samples and Settings

Guanophilic Fungi of Mouse-Tailed Bats

Generalized calcinosis cutis associated with disseminated paecilomycosis in a dog

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