Paediatric cornea crosslinking current strategies: A review

Prasher, Pawan; Sharma, Ashok; Sharma, Rajan; Vig, Vipan K.; Nirankari, Verinder S.

doi:10.1016/j.aopr.2022.11.002

Cited by 2 publications

(1 citation statement)

References 102 publications

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“…Performing CXL in children is done under the same protocols as adults, however, after performing crosslinking in the pediatric population, it is critical to counsel the patients and their families about the need for long-term follow-up and the potential need for repeat crosslinking. While CXL is effective in the pediatric population with similar complication rates as adults, the potential for further progression after CXL is higher in the pediatric population [20]. Special considerations such as the potential need for general anesthesia need to be considered when performing CXL in a younger population.…”

Section: Timing Of Crosslinkingmentioning

confidence: 99%

Update on corneal crosslinking for keratoconus and corneal ectasia

Greenstein,

Hersh

2024

Current Opinion in Ophthalmology

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Purpose of review To review corneal crosslinking for keratoconus and corneal ectasia, and recent developments in the field. This study will review the mechanism of crosslinking, clinical approaches, current results, and potential future innovations. Recent findings Corneal crosslinking for keratoconus was first approved by U.S. FDA in 2016. Recent studies have confirmed the general long-term efficacy of the procedure in decreasing progression of keratoconus and corneal ectasia. New types of crosslinking protocols, such as transepithelial treatments, are under investigation. In addition, adjunctive procedures have been developed to improve corneal contour and visual function in these patients. Summary Crosslinking has been found to be well tolerated and effective with the goal of decreasing progression of ectatic corneal diseases, keratoconus and corneal ectasia after refractive surgery. Studies have shown its long-term efficacy. New techniques of crosslinking and adjunctive procedures may further improve treatments and results.

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Section: Timing Of Crosslinkingmentioning

confidence: 99%

Update on corneal crosslinking for keratoconus and corneal ectasia

Greenstein,

Hersh

2024

Current Opinion in Ophthalmology

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Biomimetic Corneal Stroma for Scarless Corneal Wound Healing via Structural Restoration and Microenvironment Modulation

Huang,

Jiang,

et al. 2023

Adv Healthcare Materials

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Corneal injury‐induced stromal scarring causes the most common subtype of corneal blindness, and there is an unmet need to promote scarless corneal wound healing. Herein, a biomimetic corneal stroma with immunomodulatory properties is bioengineered for scarless corneal defect repair. First, a fully defined serum‐free system is established to derive stromal keratocytes (hAESC‐SKs) from a current Good Manufacturing Practice (cGMP)‐grade human amniotic epithelial stem cells (hAESCs), and RNA‐seq is used to validate the phenotypic transition. Moreover, hAESC‐SKs are shown to possess robust immunomodulatory properties in addition to the keratocyte phenotype. Inspired by the corneal stromal extracellular matrix (ECM), a photocurable gelatin‐based hydrogel is fabricated to serve as a scaffold for hAESC‐SKs for bioengineering of a biomimetic corneal stroma. The rabbit corneal defect model is used to confirm that this biomimetic corneal stroma rapidly restores the corneal structure, and effectively reshapes the tissue microenvironment via proteoglycan secretion to promote transparency and inhibition of the inflammatory cascade to alleviate fibrosis, which synergistically reduces scar formation by ≈75% in addition to promoting wound healing. Overall, the strategy proposed here provides a promising solution for scarless corneal defect repair.

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Paediatric cornea crosslinking current strategies: A review

Cited by 2 publications

References 102 publications

Update on corneal crosslinking for keratoconus and corneal ectasia

Update on corneal crosslinking for keratoconus and corneal ectasia

Biomimetic Corneal Stroma for Scarless Corneal Wound Healing via Structural Restoration and Microenvironment Modulation

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