Paediatric MOG-antibody disease presenting with intracranial hypertension and unilateral vision loss without radiological evidence of optic neuritis

Maran, Jack Jonathan; Sharpe, Cynthia; Carroll, Stuart

doi:10.1016/j.jneuroim.2023.578083

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…Table 4 documents the demographics and reported cause of each case of optic neuritis within the last year. Of note, most cases were post-infectious [ 9 , 12 ] or related to MOG antibody disease [ 11 , 14 ]. All patients presented with decreased visual acuity [ 9 - 14 ]; however, not all patients presented with optic pain [ 9 , 10 , 14 ] and dyschromatopsia.…”

Section: Discussionmentioning

confidence: 99%

“…Of note, most cases were post-infectious [ 9 , 12 ] or related to MOG antibody disease [ 11 , 14 ]. All patients presented with decreased visual acuity [ 9 - 14 ]; however, not all patients presented with optic pain [ 9 , 10 , 14 ] and dyschromatopsia. In all six cases, each patient was treated with intravenous methylprednisone with a resolution of symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…In all six cases, each patient was treated with intravenous methylprednisone with a resolution of symptoms. In cases where the patient was followed up several months later, recurrence of disease [ 11 ] or long-term functional deficits were found upon examination [ 14 ]. Interestingly, both of the mentioned cases of optic neuritis were found to be caused by MOG antibody disease.…”

Section: Discussionmentioning

confidence: 99%

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Optic Neuritis in a 15-Year-Old Female Patient: A Case Report and Literature Review

Chan,

Pereira

2024

Cureus

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Optic neuritis represents a rare clinical entity leading to vision loss within the pediatric population. While not an urgent or life-threatening condition, optic neuritis may serve as a manifestation of various systemic diseases. When pediatric patients present with complaints of vision loss, it is imperative to consider optic neuritis as a potential differential diagnosis. This prompts further investigation to exclude systemic diseases capable of causing substantial morbidity. This article details a case report involving optic neuritis in a 15-year-old Hispanic female, outlining the investigation and management approach. Additionally, a review of the literature identifies six recent case reports documenting pediatric optic neuritis within the last year.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Optic Neuritis in a 15-Year-Old Female Patient: A Case Report and Literature Review

Chan,

Pereira

2024

Cureus

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Intracranial Hypertension and Optic Neuritis in Two Unrelated Seronegative Cases

Nejad Shahrokh Abadi,

Shekarchian,

Toosi

et al. 2024

Clinical Case Reports

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Intracranial Hypertension (ICHT) is identified as the elevation of Cerebrospinal Fluid (CSF) pressure in patients devoid of any underlying causes. Optic Neuritis (ON) is not typically seen as a complication of ICHT, and patients diagnosed with concurrent manifestation of both these disorders usually have some identifiable underlying cause. In this report, we highlight the clinical and para‐clinical findings in two unrelated children presenting with high CSF opening pressures and Optic neuritis in the absence of any identifiable neurological or immunological cause.

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Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): current understanding and challenges

2023

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New diagnostic criteria for myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) have recently been proposed, distinguishing this syndrome from other inflammatory diseases of the central nervous system. Seropositivity status for MOG-IgG autoantibodies is important for diagnosing MOGAD, but only in the context of robust clinical characterization and cautious interpretation of neuroimaging. Over the last several years, access to cell-based assay (CBA) techniques has improved diagnostic accuracy, yet the positive predictive value of serum MOG-IgG values varies with the prevalence of MOGAD in any given patient population. For this reason, possible alternative diagnoses need to be considered, and low MOG-IgG titers need to be carefully weighted. In this review, cardinal clinical features of MOGAD are discussed. Key challenges to the current understanding of MOGAD are also highlighted, including uncertainty regarding the specificity and pathogenicity of MOG autoantibodies, the need to identify immunopathologic targets for future therapies, the quest to validate biomarkers that facilitate diagnosis and detect disease activity, and the importance of deciphering which patients with MOGAD require long-term immunotherapy.

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Paediatric MOG-antibody disease presenting with intracranial hypertension and unilateral vision loss without radiological evidence of optic neuritis

Cited by 5 publications

References 31 publications

Optic Neuritis in a 15-Year-Old Female Patient: A Case Report and Literature Review

Optic Neuritis in a 15-Year-Old Female Patient: A Case Report and Literature Review

Intracranial Hypertension and Optic Neuritis in Two Unrelated Seronegative Cases

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): current understanding and challenges

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