Paediatric origins of adult lung disease bullet 6: Paediatric origins of adult lung disease

Mutius, Erika von

doi:10.1136/thorax.56.2.153

Cited by 75 publications

(6 citation statements)

References 52 publications

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“…33–41 The study is particularly consistent with the recent results of the NAC Manchester Asthma and Allergy Study Group in preschool children, which have shown that both transient and persistent wheezers have reduced lung function compared with nonwheezing children. 39 Interestingly, the latter study group was also able to show that diminished lung function in high risk infants at one month of age preceded the subsequent occurrence of wheezing and other respiratory symptoms.…”

Section: Discussionsupporting

confidence: 87%

Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non-smoking mothers

Jędrychowski

Perera

Maugeri

et al. 2010

Paediatric and Perinatal Epidemiology

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SUMMARY Impaired fetal development is associated with a number of adult chronic diseases and it is believed that these associations arise as a result of the phenomenon of “epigenetic programming”, which involves persisting changes in structure and function of various body organs caused by ambient factors during critical and vulnerable periods of early development. The main goal of the study was to assess the association between lung function in early childhood and prenatal exposure to fine particulate matter (PM2.5 ), which represents a wide range of chemical compounds potentially hazardous for fetal development. Among pregnant women recruited prenatally to the study personal measurements of PM2.5 was performed over 48 hours in the second trimester of pregnancy. After delivery, infants were followed over five years and the interviewers visited participants at their homes to record children’s respiratory symptoms every three months in the child’s first two years of life and every 6 months later. In the fifth year of the follow-up, children were invited for standard lung function testing and quantified by FVC, FEV1 and FEV05 levels. Material consisted of 176 children of nonsmoking mothers, who performed at least two acceptable spirometry measurements. Multivariable linear regression model showed a significant deficit of FVC at the highest quartile of PM2.5 exposure (beta coefficient = − 91.9 , P = 0.008), after adjustment for covariates (age, gender, birth weight, height and wheezing). Also FEV1 level in children was inversely correlated with prenatal exposure to PM2.5, and the average FEV1 deficit amounted to 87.7 ml (P = 0.008) at the higher level of exposure. Although the effect of PM2.5 exposure on FEV05 was proportionally weaker (−72.7, P = 0.026) it was significant as well. The lung function level was inversely and significantly associated with the wheezing recorded over the follow-up. The findings showed that significant lung function deficits in early childhood is associated with prenatal exposure to fine particulate matter, which may affect fetal lung growth.

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Section: Discussionsupporting

confidence: 87%

Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non-smoking mothers

Jędrychowski

Perera

Maugeri

et al. 2010

Paediatric and Perinatal Epidemiology

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“…Asthma is a common disease in children and the origin of the majority of adult cases, indicating that childhood events have an important role in asthma pathogenesis [ 1 – 3 ]. Childhood is an important period for the maturation of the immune system, and specific infections may alter immunologic programming, which plays a critical role in the progression of allergic airways disease (AAD) in adulthood.…”

Section: Introductionmentioning

confidence: 99%

Neonatal Streptococcus pneumoniae Infection May Aggravate Adulthood Allergic Airways Disease in Association with IL-17A

et al. 2015

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Epidemiologic studies have demonstrated that some bacteria colonization or infections in early-life increased the risk for subsequent asthma development. However, little is known about the mechanisms by which early-life bacterial infection increases this risk. The aim of this study was to investigate the effect of neonatal Streptococcus pneumoniae infection on the development of adulthood asthma, and to explore the possible mechanism. A non-lethal S. pneumoniae lung infection was established by intranasal inoculation of neonatal (1-week-old) female mice with D39. Mice were sensitized and challenged with ovalbumin in adulthood to induce allergic airways disease (AAD). Twenty-four hours later, the lungs and bronchoalveolar lavage fluid (BALF) were collected to assess AAD. Neonatal S. pneumoniae infection exacerbated adulthood hallmark features of AAD, with enhanced airway hyperresponsiveness and increased neutrophil recruitment into the airways, increased Th17 cells and interleukin (IL)-17A productions. Depletion of IL-17A by i.p. injection of a neutralizing monoclonal antibody reduced neutrophil recruitment into the airways, alleviated airway inflammation and decreased airway hyperresponsiveness. Furthermore, IL-17A depletion partially restored levels of inteferon-γ, but had no effect on the release of IL-5 or IL-13. Our data suggest that neonatal S. pneumoniae infection may promote the development of adulthood asthma in association with increased IL-17A production.

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“…Previous clinical and epidemiologic data have demonstrated links between early immune functioning and later physical health outcomes [ 10 - 12 ]. In general, severe infection has been shown to be associated with increased risk of physical health problems in adolescence and later adulthood.…”

Section: Introductionmentioning

confidence: 99%

Association between infection early in life and mental disorders among youth in the community: a cross-sectional study

Goodwin

2011

BMC Public Health

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BackgroundThe objective of this study was to examine the association between infection early in life and mental disorders among youth in the community.MethodsData were drawn from the MECA (Methods in Epidemiology of Child and Adolescent psychopathology), a community-based study of 1,285 youth in the United States conducted in 1992. Multiple logistic regression analyses were used to investigate the association between parent/caregiver-reported infection early in life and DSM/DISC diagnoses of mental disorders at ages 9-17.ResultsInfection early in life was associated with a significantly increased odds of major depression (OR = 3.9), social phobia (OR = 5.8), overanxious disorder (OR = 6.1), panic disorder (OR = 12.1), and oppositional defiant disorder (OR = 3.7).ConclusionsThese findings are consistent with and extend previous results by providing new evidence suggesting a link between infection early in life and increased risk of depression and anxiety disorders among youth. These results should be considered preliminary. Replication of these findings with longitudinal epidemiologic data is needed. Possible mechanisms are discussed.

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Paediatric origins of adult lung disease bullet 6: Paediatric origins of adult lung disease

Cited by 75 publications

References 52 publications

Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non-smoking mothers

Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non-smoking mothers

Neonatal Streptococcus pneumoniae Infection May Aggravate Adulthood Allergic Airways Disease in Association with IL-17A

Association between infection early in life and mental disorders among youth in the community: a cross-sectional study

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