Paediatric outcome following infertility management/genetic outcome

DOOR (deafness, onychodystrophy, osteodystrophy, mental retardation) syndrome in one of the twins after conception with intracytoplasmic sperm injection

“…Demographic background of the ICSI parents such as higher parental age, longer period of infertility prior to conception, pre-existing parental and genetic conditions have so far been addressed as confounding factors for the relatively excess number anomalies in ICSI children. Animal research and recent reports in literature also suggest that there may be a low risk of epigenetic defects and rare diseases related to imprinting disorders caused by ICSI [Boundelle, 2004;Maher, 2005]. Since no parental factors have been identified to increase the risk of DOOR syndrome, we do not know whether parental demographics or the ICSI procedure itself had a role in the development of DOOR syndrome in the present case.…”

“…Higher rate of unbalanced chromosomal anomalies and de novo chromosomal anomalies have also been related to ICSI [Boundelle, 2004]. Altered hormonal environment, the loss of selective mechanisms against morphologically abnormal sperm in vivo, and point mutations due to various chemical exposures during the in vitro phase have raised concerns against the procedure [Boundelle, 2004].…”

“…Higher rate of unbalanced chromosomal anomalies and de novo chromosomal anomalies have also been related to ICSI [Boundelle, 2004]. Altered hormonal environment, the loss of selective mechanisms against morphologically abnormal sperm in vivo, and point mutations due to various chemical exposures during the in vitro phase have raised concerns against the procedure [Boundelle, 2004]. Demographic background of the ICSI parents such as higher parental age, longer period of infertility prior to conception, pre-existing parental and genetic conditions have so far been addressed as confounding factors for the relatively excess number anomalies in ICSI children.…”

Synthesis and characterizations of nanosized iron(II) hydroxide and iron(II) hydroxide/poly(vinyl alcohol) nanocomposite

“…Within the past few years, several reports have determined that there may be a link between ICSI and an increased risk of birth defects and specific imprinting disorders such as Angelman syndrome and Beckwith–Wiedemann syndrome [Maher, 2005]. Higher rate of unbalanced chromosomal anomalies and de novo chromosomal anomalies have also been related to ICSI [Boundelle, 2004]. Altered hormonal environment, the loss of selective mechanisms against morphologically abnormal sperm in vivo, and point mutations due to various chemical exposures during the in vitro phase have raised concerns against the procedure [Boundelle, 2004].…”

To Be or not to Be? A Critical Appraisal of the Welfare of Children Conceived through New Reproductive Technologies

“…Follow up studies of ICSI-conceived children show that they have an increased risk of major congenital malformations and reduced future fertility (Hansen et al, 2002;Debaun et al, 2003;Maher et al, 2003;Bonduelle, 2004;Ponjaert-Kristoff ersen et al, 2004;Sutcliff e, 2004;Bonduelle et al, 2005;Belva et al, 2006;Sutcliff e et al, 2006), the most likely causes of which are thought to be sperm characteristics rather than the procedure itself.…”