Paediatric Ovarian Dysgerminoma: A Case Report

Adhikari, Siddhant; Joti, Santosh; Chhetri, Parvat Kuwar

doi:10.31729/jnma.7894

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Semiologically, the clinical picture usually presents with progressive abdominal pain and a rapidly growing palpable abdomino-pelvic mass. In adolescents and even in women of childbearing age, pregnancy may be implicated as a triggering factor for the tumour, suggesting a hormonal component associated with tumourogenesis [21].…”

Section: Discussionmentioning

confidence: 99%

Giant dysgerminoma with pelvic metastases at the time of puberty: A case report and review of the literature

Medina Torres,

Restrepo Becerra

2023

Magna Sci. UCEVA

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This study aims to provide a comprehensive insight into the clinical presentation, diagnostic challenges and management strategies associated with a rare occurrence of giant dysgerminoma with pelvic metastases in an adolescent patient. We intend to add valuable information to the medical literature that may help to better understand and manage similar cases in the future, making this case report potentially valuable to clinicians and researchers in the fields of gynaecological oncology and paediatric oncology. Germ cells, the precursors of the ova in women and sperm in men, can give rise to germ cell tumours if their migration goes wrong during embryogenesis. These tumours, which can be malignant or benign, are generally rare. In particular, germ cell lesions in women are usually benign, whereas in men they are often malignant. These tumours can present as intra- or extragonadal masses due to the migratory nature of the germ cells. Dysgerminoma, a rare malignant germ cell tumour, is more common in men than testicular seminoma. In women, dysgerminomas account for 1-2% of malignant ovarian tumours and present as exotic lesions. They are usually relatively small, but giant lesions have been reported. They also exhibit rapid growth and a characteristic lobulated surface, retaining the ovarian shape. Extra-ovarian presentations are rare but may extend into the abdominal region. In men, seminomas may occur extra-testicularly, particularly in the mediastinum. Dysgerminomas respond well to radiotherapy and chemotherapy, with survival rates of over 90% at five years with timely and appropriate treatment worldwide

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Section: Discussionmentioning

confidence: 99%

Giant dysgerminoma with pelvic metastases at the time of puberty: A case report and review of the literature

Medina Torres,

Restrepo Becerra

2023

Magna Sci. UCEVA

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“…Most dysgerminomas are asymptomatic and quite large at diagnosis [100]. Clinical manifestations include abdominal pain, abdominal distention, palpable mass, decreased appetite, nausea/vomiting and ovarian torsion [101].…”

Section: Dysgerminomamentioning

confidence: 99%

“…With regard to the treatment of dysgerminoma, effective therapeutic options include conservative surgery, chemotherapy and irradiation [100,107]. Most patients present with early-stage disease, and, hence, surgery alone can be curative.…”

Section: Dysgerminomamentioning

confidence: 99%

Ovarian Masses in Children and Adolescents: A Review of the Literature with Emphasis on the Diagnostic Approach

et al. 2023

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Most abdominal masses in the pediatric population derive from the ovaries. Ovarian masses can occur in all ages, although their incidence, clinical presentation and histological distribution vary among different age groups. Children and adolescents may develop non-neoplastic ovarian lesions, such as functional cysts, endometrioma, torsion, abscess and lymphangioma as well as neoplasms, which are divided into germ cell, epithelial, sex-cord stromal and miscellaneous tumors. Germ cell tumors account for the majority of ovarian neoplasms in the pediatric population, while adults most frequently present with epithelial tumors. Mature teratoma is the most common ovarian neoplasm in children and adolescents, whereas dysgerminoma constitutes the most frequent ovarian malignancy. Clinical manifestations generally include abdominal pain, palpable mass, nausea/vomiting and endocrine alterations, such as menstrual abnormalities, precocious puberty and virilization. During the investigation of pediatric ovarian masses, the most important objective is to evaluate the likelihood of malignancy since the management of benign and malignant lesions is fundamentally different. The presence of solid components, large size and heterogenous appearance on transabdominal ultrasonography, magnetic resonance imaging and computed tomography indicate an increased risk of malignancy. Useful tumor markers that raise concern for ovarian cancer in children and adolescents include alpha-fetoprotein, lactate dehydrogenase, beta subunit of human chorionic gonadotropin, cancer antigen 125 and inhibin. However, their serum levels can neither confirm nor exclude malignancy. Management of pediatric ovarian masses needs to be curative and, when feasible, function-preserving and minimally invasive. Children and adolescents with an ovarian mass should be treated in specialized centers to avoid unnecessary oophorectomies and ensure the best possible outcome.

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“…El tratamiento actual consiste en la cirugía conservadora de fertilidad, quimioterapia adyuvante y radiación postoperatoria. La sobrevida en 5 años está entre el 75% y 90% en los estadios tempranos (9) .…”

Section: Introductionunclassified

Disgerminoma puro de ovario gigante en paciente joven de 19 años

Pelaes-Cruz,

Malpartida-Huamancaja,

Vicuña- Victorio

et al. 2024

Rev peru ginecol obstet.

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El disgerminoma de ovario es una neoplasia muy infrecuente. Se presentamayormente en mujeres jóvenes con manifestaciones clínicas inespecíficas, aunquepueden señalar dolor abdominal, sensación de masa y alteraciones menstruales.Se comunica el caso de una paciente joven de 19 años multípara con sensación demasa intraabdominal, de crecimiento progresivo y asociado a dolor de tipo opresivo.En el examen tomográfico se encontró una masa anexial dependiente de ovario,por lo que se le practicó una anexectomía derecha y biopsia por congelación másestadiaje. La evaluación macroscópica evidenció una tumoración de 25 x 20 x 13cm, que pesaba 5,760 gramos. Mediante evaluación microscópica y estudios deinmunohistoquímica se la diagnosticó como disgerminoma puro. En base al tamañopromedio y antecedentes, fue catalogada como disgerminoma gigante.

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Paediatric Ovarian Dysgerminoma: A Case Report

Cited by 7 publications

References 11 publications

Giant dysgerminoma with pelvic metastases at the time of puberty: A case report and review of the literature

Giant dysgerminoma with pelvic metastases at the time of puberty: A case report and review of the literature

Ovarian Masses in Children and Adolescents: A Review of the Literature with Emphasis on the Diagnostic Approach

Disgerminoma puro de ovario gigante en paciente joven de 19 años

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