Paediatric solid oral dosage forms for combination products: Improving in vitro swallowability of minitablets using binary mixtures with pellets

Patient Acceptability and Preferences for Solid Oral Dosage Form Drug Product Attributes: A Scoping Review

“…Future drug product development is likely to customize existing approaches and make use of a contemporary SODF, such as pellets and minitablets, 64 to improve acceptability and thus adherence for all individuals, while also addressing the specific needs of particular patient populations, such as pediatrics, older adults, those with dysphagia, and those with cognitive impairment. 6 To deliver a truly patient-centered approach to drug product design, patients need to be more actively involved in designing drug products so as to directly determine their priorities and what is important to them.…”

“…The EMA recently published a letter of support 63 for testing oral drug product acceptability in children <12 years using the ClinSearch Acceptability Score Test ® , which was developed following publication of the EMA guideline on pharmaceutical development of drug products for pediatric use. 11 Future drug product development is likely to customize existing approaches and make use of a contemporary SODF, such as pellets and minitablets, 64 to improve acceptability and thus adherence for all individuals, while also addressing the specific needs of particular patient populations, such as pediatrics, older adults, those with dysphagia, and those with cognitive impairment. 6 To deliver a truly patient-centered approach to drug product design, patients need to be more actively involved in designing drug products so as to directly determine their priorities and what is important to them.…”