Paediatric solid tumours in Nigerian children: A changing pattern?

Tanko, Matthew N.; Echejoh, GO; Manasseh, Nanfwang A; Mandong, Mafala B; Uba, AF

doi:10.4103/0189-6725.48567

Cited by 34 publications

(39 citation statements)

References 10 publications

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“…According to literature data, osteosarcoma is often found in the pre pubertal years and the location on the lower third of the femur is the most common in 47% of cases (Grimer et al, 2005). Carcinomas are rare in children; the rate of these cancers in our study was 3% is comparable to those of authors of Nigeria and South Africa (Tanko et al, 2009;Hadley et al, 2012).…”

Section: 81 Evaluation Of the Histo-epidemiological Profile Of Solidsupporting

confidence: 77%

Evaluation of the Histo-Epidemiological Profile of Solid Childhood Cancers in Togo

Darré

Maneh²,

Boume³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Cancer is a subject of continuing concern, more common in adults than in children, but often with a poor outcome in the latter. Our study set itself the objective to describe the epidemiological and histological aspects of solid cancers in children in Togo. Materials and Methods: This descriptive, cross-sectional study focused on cases of solid cancers in children diagnosed from 2010 to 2014 (5 years) at the pathology laboratory of the Tokoin teaching hospital. Data were collected from the records of that laboratory. Results: We collected 66 cases of childhood cancer representing 5% of all solid cancers. The annual incidence was 13.2 cases. The sex ratio (M/F) was 1.4; mean age was of 7.2±1.6 years. The age group most affected was that of 5-9 years (40.9%). Four histological groups of solid childhood cancers were listed: lymphoma (n=34 cases; 51.5%), embryonic cancer (n=17 cases; 25.8%), sarcomas (n=13 cases; 19.7%) and carcinoma (n=2 cases; 3%). The most common histological types were Burkitt lymphoma (36.4%), nephroblastoma (10.6%) and retinoblastoma (10.6%). Conclusions: This study shows that solid cancers in children are relatively frequent in Togo with a male predominance. They are still largely dominated by Burkitt lymphoma, followed by retinoblastoma and nephroblastoma.

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Section: 81 Evaluation Of the Histo-epidemiological Profile Of Solidsupporting

confidence: 77%

Evaluation of the Histo-Epidemiological Profile of Solid Childhood Cancers in Togo

Darré

Maneh²,

Boume³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…This pattern is similar to the findings in Ibadan, [3,7,9] Jos, [16] Lagos, [2] Ife, [10] and Western Kenya. [28] Burkitt's lymphoma is the commonest solid malignant tumour of childhood seen in Ibadan, [3,7,9] Ife, [10] Lagos, [2] Ghana and Western Kenya.…”

Section: Discussionsupporting

confidence: 79%

“…Burkitt's lymphoma is the commonest paediatric malignant tumour seen in various studies in Nigeria [2,3,[7][8][9][10][11][12][13][14][15][16][17][18][19]. Common childhood malignant neoplasms in other parts of the world include intracranial tumours; neuroblastoma, osteosarcoma, Ewing's sarcoma, and soft tissue sarcoma.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Pattern of Childhood Solid Tumours in Ilorin: A 28-Year Retrospective Review

Omotayo¹,

Duduyemi²,

Mo³

et al. 2013

AJMSM

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Background: Cancers and other non-communicable diseases were thought to be unimportant public health problems in developing countries because of the overwhelmingly high prevalence of communicable diseases. However, with improved health care facilities and extensive national immunization programmes, coupled with generally improving socio-economic status, malignant diseases are beginning to account for a significant percentage of childhood morbidity and mortality. The study aims to determine the morphological pattern, burden and demographic characteristics of paediatric solid malignancies seen at the University of Ilorin Teaching Hospital between January 1979 and December 2006. Methodology: The demographic characteristics of all cases of malignant solid neoplasms seen in children between the ages of 0 and 15 years were retrieved from the archives and recorded. The histopathological, cytological and the post-mortem slides of the recorded cases were retrieved and reviewed. Special staining techniques were employed where necessary. Results: Three hundred and twenty four cases of childhood solid malignant neoplasms were diagnosed over the study period. The prevalence of childhood malignant solid tumours in Ilorin is 311 per million children. The commonest tumour in this study is lymphoma representing 55.56% of total paediatric malignant solid neoplasms seen. Burkitt's lymphoma constituted the largest single entity (80% of all lymphomas). This was followed by nephroblastoma, retinoblastoma and bone tumours which accounted for 8.33%, 7.72% and 4.63% respectively. Intracranial tumours were relatively rare. Conclusion: The pattern of paediatric malignant solid neoplasms seen in Ilorin is similar to what obtains in other parts of Nigeria and African countries. Burkitt's Lymphoma is the commonest childhood malignancy in this study. Nephroblastoma is the second commonest childhood malignant solid neoplasm in Ilorin as against what was observed in other centres such as Ibadan, Ife and Jos where retinoblastoma is the second commonest after lymphoma.

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“…Considering studies that were based exclusively on solid tumours, Burkitt Lymphoma remained the commonest solid tumour in most centres with the exception of Jos and Lagos. The placing of Burkitt lymphoma as the third most common tumour in the review by Tanko et al 28 from Jos needs to be interpreted with caution bearing in mind that Burkitt Lymphoma is mostly diagnosed through cytology of fine needle aspirate and so the Jos study which was based on histology of solid tumours is likely to have an underrepresentation of Burkitt Lymphoma 17 . The predominance of Retinoblastoma among solid tumours in Lagos is similar to the finding in Ibadan which is in the same geopolitical zone.…”

Section: Discussionmentioning

confidence: 99%

“…In the fifth centre, Zaria, Burkitt Lymphoma and Retinoblastoma were of equal frequency and ranked highest 27 . Out of the remaining two centres, Jos reported Rhabdomyosarcoma as the predominant solid tumour accounting for 31 percent of the tumours with Burkitt Lymphoma being the third most common and accounted for 13.8 percent of the tumours while in Lagos, Retinoblastoma was reported to be the predominant tumour and accounted for 21% of the tumours whereas Burkitt Lymphoma accounted for only 2% of the tumours 28,29 . …”

Section: Prevalencementioning

confidence: 98%

A review of the literature on childhood Burkitt lymphoma in Nigeria

B¹

2016

Nig. J. Paed.

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Paediatric solid tumours in Nigerian children: A changing pattern?

Abstract: Based on the result of our study, we conclude that the commonest solid malignancy of childhood in Jos, Nigeria is rhabdomyosarcoma. This has implications for diagnosis, management and prognosis of theses soft tissue sarcomas in our paediatric population.

Cited by 34 publications

References 10 publications

Evaluation of the Histo-Epidemiological Profile of Solid Childhood Cancers in Togo

Evaluation of the Histo-Epidemiological Profile of Solid Childhood Cancers in Togo

Histopathological Pattern of Childhood Solid Tumours in Ilorin: A 28-Year Retrospective Review

A review of the literature on childhood Burkitt lymphoma in Nigeria

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