Paediatric T cell Lymphoma with Nephrotic Syndrome: A Rare Association

Abstract

Renal involvement is frequent in hematologic malignancies especially Hodgkin's lymphoma. Renal complications in children with malignancies primarily arise from tumour lysis syndrome, malignant infiltration or obstruction of the urinary tract, deposits of immunoglobulin fractions or crystals, renal infiltration by malignant cells, paraneoplastic or storage glomerulopathies. Nephrotic syndrome has been described in B cell type Non Hodgkin's lymphomas. There are very few reports of association of T cell lymphoma and nephrotic syndrome in pediatric patients. We present a case of peripheral T cell lymphoma with nephrotic syndrome in a 10 year old boy.

Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases

“…A handful of cases are reported in the form of single case reports from India at different time points, on lymphoma infiltration, intravascular lymphoma, and primary renal lymphoma causing renal dysfunction. [ 4 5 6 7 8 9 10 11 12 13 14 15 ] We present here a case series of patients who have undergone renal biopsy in the evaluation of intrinsic causes of renal injury (i.e. lymphomatous infiltration, tubulointerstitial injury and paraneoplastic glomerulopathy).…”

“…[ 16 ] Few case reports are associated with T-cell neoplasms. [ 7 17 18 ] Grade of NHL were low in 5, intermediate in 2 and high grade in 2 cases. Our series is in conjunction with literature in that low-grade lymphomas are more common to affect glomerular compartment versus nonglomerular compartment in high-grade lymphomas.…”