“…While it has been used in children and adolescents suffering from these various disorders for many years, more recently it is also being used in younger patients and patients with various diseases associated to severe bilateral facial deformities, such as Goldenhar syndrome, Treacher Collins syndrome, achondroplasia, craniostenosis, and Down syndrome [1][2][3]. In these patients, NPPV represents an interesting noninvasive alternative to tracheostomy, which is associated with significant morbidity and may impair normal development and, particularly, language development [4,5]. Discomfort and disruption of social and family life are common consequences of patients with a tracheostomy.…”