Paediatric Ulcerative Colitis Surgery: Italian Survey

Mattioli, Girolamo; Barabino, A.; Aloi, Marina; Arrigo, S.; Caldaro, Tamara; Carlucci, Marcello; Cucchiara, Salvatore; Angelis, Paola De; Leo, Grazia Di; Illiceto, M.T.; Impellizzeri, Pietro; Leonelli, Lorenzo; Lisi, Gabriele; Lombardi, G.; Martelossi, Stefano; Martinelli, Massimo; Miele, Evelina; Randazzo, A; Romano, Claudio; Romeo, Carmelo; Romeo, Erminia; Selvaggi, Francesco; Valenti, S; Dall’Oglio, Luigi

doi:10.1093/ecco-jcc/jjv065

Cited by 14 publications

(3 citation statements)

References 29 publications

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“…In the Mayo Clinic's systematic review (2412 UC/268 FAP), < 30-day short-term IPAA postoperative complication rates were low and long-term functional outcomes were good, with an overall pouch failure rate of 8% (95% CI 6-12%-median follow-up 109 months), highlighting the safety of this operation in pediatric patients [76]. Although pouchitis is more likely to occur in the pediatric population (related to a younger age at diagnosis), the majority has good long-term functional outcomes with regard to stool frequency [77,78].…”

Section: Itemmentioning

confidence: 99%

Inflammatory bowel disease position statement of the Italian Society of Colorectal Surgery (SICCR): ulcerative colitis

et al. 2020

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The Italian Society of Colorectal Surgery (SICCR) promoted the project reported here, which consists of a Position Statement of Italian colorectal surgeons to address the surgical aspects of ulcerative colitis management. Members of the society were invited to express their opinions on several items proposed by the writing committee, based on evidence available in the literature. The results are presented, focusing on relevant points. The present paper is not an alternative to available guidelines; rather, it offers a snapshot of the attitudes of SICCR surgeons about the surgical treatment of ulcerative colitis. The committee was able to identify some points of major disagreement and suggested strategies to improve the quality of available data and acceptance of guidelines.

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Section: Itemmentioning

confidence: 99%

Inflammatory bowel disease position statement of the Italian Society of Colorectal Surgery (SICCR): ulcerative colitis

et al. 2020

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“…3,4 Even though it is easier to get control than other IBD patients, a few patients still experience unbeneficial outcomes, such as loss of control under monotherapy or surgical treatment. 5,6 Even the loss of response to biological intervention by biologic would occur in the unfortunate. 7,8 Constant transition of therapy is common because of drug resistance or intolerance.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 Surgery is an unavoidable method for patients presented no response to medications or with identified colorectal neoplasm. 5,6 Colectomy, as a paradigm surgery for UC, severely affects the patients' quality of life. 3 No general validated definition has been identified for treatment failures (TFs) in UC patients.…”

Section: Introductionmentioning

confidence: 99%

A Novel Nomogram Combining Mucus Barrier Index for Predicting Treatment Failures in Ulcerative Colitis

Wang¹,

Huang²,

Zhou³

et al. 2023

JIR

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Background: Treatment failures (TFs) generally exist in the course of ulcerative colitis (UC), while early reliable predictors of TFs are still lacking. We aimed to generate nomograms for the prediction of TFs. Methods: In this retrospective case-control study, the endpoint was the occurrence of TFs, which included medically associated treatment failures and surgery-associated treatment failures (colectomy). Clinical features and mucus integrity evident by goblet cells (GCs) number, expression levels of MUC2 and SLC26A3 were enrolled in the univariate analysis. Nomogram performance was evaluated by discrimination and calibration. Results: We identified 256 UC patients at our center from January 2010 to June 2022. Fourteen variables for TFs and 9 for colectomy were identified by univariate analysis. Five baseline indices were incorporated into the nomogram for the prediction of TFs: area of GCs, age at diagnosis, disease duration, hemoglobin, and Mayo score. The model was presented with decent discrimination (C index of 0.822) and well calibration. In addition, the colectomy predictive nomogram was built using MUC2 intensity, age at onset, and Mayo score with a good discrimination (C index of 0.92). Conclusion: Nomograms based on comprehensive factors including mucus barrier function were developed to predict TFs in UC patients with great discrimination, which may serve as practical tools aiming to identify high-risk subgroups warrant timely intervention.

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Robotic Assisted Proctectomy and Ileal J-Pouch Anorectal Anastomosis

Pio

Mattioli

2017

Pediatric Robotic Surgery

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Paediatric Ulcerative Colitis Surgery: Italian Survey

Cited by 14 publications

References 29 publications

Inflammatory bowel disease position statement of the Italian Society of Colorectal Surgery (SICCR): ulcerative colitis

Inflammatory bowel disease position statement of the Italian Society of Colorectal Surgery (SICCR): ulcerative colitis

A Novel Nomogram Combining Mucus Barrier Index for Predicting Treatment Failures in Ulcerative Colitis

Robotic Assisted Proctectomy and Ileal J-Pouch Anorectal Anastomosis

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