Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters

Zhang, Yan; Li, Yao; Li, Chang; Zhao, Yani; Xu, Li; Ma, Shengming; Lin, Fang; Xie, Yanhua; An, Junming; Wang, Siwang

doi:10.1016/j.phymed.2023.154957

Cited by 11 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Insulin resistance is one of the factors causing HUA. Insulin resistance is one of the factors causing HUA, under insulin resistance, the intermediate products of glycolysis to 5-phosphate ribose and ribose phosphate transfer, resulting in an increase in the production of blood uric acid, but also increase the concentration of triglycerides [21], the latter cause more free fatty acid production, accelerate the decomposition of ATP, also caused by an increase in the production of blood uric acid [22]; insulin resistance can increase the synthesis of hepatic fat, resulting in purine metabolism disorders, and increase the production of fatty acids, which can lead to the development of HUA. Insulin resistance can also increase hepatic fat synthesis, leading to purine metabolism disorders and increasing blood uric acid levels [23].…”

Section: Discussionmentioning

confidence: 99%

Effect and mechanism of Yiqing decoction on hyperuricemia rats

Yajie Xu,

Pan Chen,

Long Sun

et al. 2024

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

According to the theory of Chinese medicine, hyperuricemia can be categorized as "dampness" and "turbid stagnation", and is usually treated by strengthening the spleen and resolving dampness, clearing heat and removing dampness, and draining turbidity and eliminating blood stasis [5]. In this study, Yiqing Fang (Patent No. 1350857), as a compound Chinese medicine composed of eight Chinese herbs, including Radix Rehmanniae Praeparata, Poria cocos, Radix Angelicae Sinensis, Radix Paeoniae Alba, Hederocallis sinensis, Zedoary, Rhizoma Atractylodes Macrocephalae, and Cyperus Rotundus, demonstrated remarkable efficacy in targeting the clinical manifestations of HUA such as Spleen Deficiency with Dampness, Phlegm and Turbidity Obstruction, Dampness-

show abstract

Section: Discussionmentioning

confidence: 99%

Effect and mechanism of Yiqing decoction on hyperuricemia rats

Yajie Xu,

Pan Chen,

Long Sun

et al. 2024

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

show abstract

Structural insights and biological activities of flavonoids: Implications for novel applications

Tang,

Wang,

Liu

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

Flavonoids are a major class of polyphenolic compounds that occur naturally in plants and are widely distributed in various dietary products. Flavonoids exhibit prominent physicochemical properties and biological activities, thereby garnering considerable attention. Notably, the physicochemical properties and functionalities of flavonoids are structurally dependent. Variations in chemical structure lead to differences in physicochemical characteristics among different flavonoid types. Structural alterations can modify these characteristics, influencing biological activities and mechanisms of action. However, these structural variations and their biological implication have not been comprehensively elucidated. In this review, we outline the structural characteristics of flavonoids, discuss biosynthesis, in vivo digestion, and absorption, and particularly emphasize the diverse biological activities and action mechanisms associated with different flavonoid structures. By summarizing the current scientific findings, we aim to elucidate the structure–activity relationships of flavonoids and provide a theoretical basis for the development of new flavonoid applications, which will help to target the design of functional molecules and moieties in the food and pharmaceutical industries for use in drug design and development.Practical Application: Understanding the structural characteristics and biological activities of flavonoids can guide the development of functional food products and dietary supplements with targeted health benefits. By leveraging the knowledge of flavonoid structure–activity relationships, food, and pharmaceutical industries can innovate formulations to enhance bioavailability and efficacy, potentially leading to the creation of tailored products for specific health conditions or dietary needs. This research lays the groundwork for the design of novel flavonoid‐based interventions aimed at promoting human health and well‐being.

show abstract