Paeoniflorin Antagonizes TNF-α-Induced L929 Fibroblastoma Cells Apoptosis by Inhibiting NF-κBp65 Activation

Lai, Xiaoyu; Wei, Jing; Ding, Xinghong

doi:10.1177/1559325818774977

Cited by 10 publications

(7 citation statements)

References 23 publications

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“…Ferulic acid promotes osteogenesis in bone marrow mesenchymal stem cells and suppresses osteoclast differentiation (Du et al, 2017; Doss et al, 2018). Paeoniflorin has a significant anti-inflammatory effect on rheumatoid arthritis (Lai et al, 2018; Xu et al, 2018). Paeoniflorin also shows antiosteoporosis activity and regulates osteoclastogenesis and osteoblastogenesis (Li and Chent 2018b; Wang et al, 2018b).…”

Section: Resultsmentioning

confidence: 99%

Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients

et al. 2019

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Hip fracture is a major public health concern, with high incidence rates in the elderly worldwide. Hip fractures are associated with increased medical costs, patient dependency on families, and higher rates of morbidity and mortality. Chinese herbal medicine (CHM) is typically characterized as cost-effective and suitable for long-term use with few side effects. To better understand the effects of CHM on hip fracture patients, we utilized a population-based database to investigate the demographic characteristics, cumulative incidence of overall mortality, readmission, reoperation, and patterns of CHM prescription. We found that CHM usage was associated with a lower risk of overall mortality [ P = 0.0009; adjusted hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.30–0.73], readmission ( P = 0.0345; adjusted HR: 0.67, 95% CI: 0.46–0.97), and reoperation ( P = 0.0009; adjusted HR: 0.57, 95% CI: 0.40–0.79) after adjustment for age, type of hip fracture, surgical treatment type, and comorbidities. We also identified the herbal formulas, single herbs, and prescription patterns for the treatment of hip fracture by using association rule mining and network analysis. For hip fracture patients, the most common CHM coprescription pattern was Du-Zhong (DZ) → Xu-Duan (XD), followed by Du-Huo-Ji-Sheng-Tang (DHJST) → Shu-Jing-Huo-Xue-Tang (SJHXT), and Gu-Sui-Bu (GSB) → Xu-Duan (XD). Furthermore, XD was the core prescription, and DZ, GSB, SJHXT, and DHJST were important prescriptions located in cluster 1 of the prescription patterns. This study provides evidence for clinical CHM use as an adjunctive therapy that offers benefits to hip fracture patients.

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Section: Resultsmentioning

confidence: 99%

Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients

et al. 2019

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“…A previous in vivo study demonstrated that paeoniflorin, the main component of SYGCT, dose-dependently decreases the secretion of pro-inflammatory mediators by inhibiting the activation of nuclear factor kappa light chain enhancer in B cells p65 (NF-κB/p65). 23 As to the prescription of GLY, a mechanistic study in a rat model revealed that the anti-inflammatory activity of GLY may be tied to the inhibition of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, and PGE2. 24 One former study using an animal experimental model also found that an extract of Magnolia officinalis, a major ingredient purified from PWS, could substantially regulate the production of inflammatory mediators by abating the NF-κB pathway.…”

Section: Discussionmentioning

confidence: 99%

The Prescription of Chinese Herbal Medicine and Risk of Endometriosis in Women with Rheumatoid Arthritis: A Population-Based Cohort Study

Chen¹,

Livneh²,

Chen³

et al. 2022

IJWH

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Purpose The systemic inflammation is believed to provide an outline of the association between rheumatoid arthritis (RA) and endometriosis. This retrospective cohort study aimed to explore the association of Chinese herbal medicine (CHM) use with the prevention of endometriosis onset in women diagnosed with RA. Methods We utilized the claims data from the National Health Insurance of Taiwan from 2000 to 2009 and excluded individuals diagnosed with endometriosis before being diagnosed with RA, using age at clinical diagnosis. After selection and propensity-score matching, a total of 5992 females aged ≧20 years old and with newly diagnosed RA but without endometriosis at baseline were included, which contained 2996 CHM users and 2996 non-CHM users. All of them were followed until the end of 2013 to measure the incidence of endometriosis. Results During the study period, we noticed that CHM users had a substantially lower incidence of endometriosis compared to non-CHM users (2.54 vs 5.19 per 1000 person-years). Use of CHM correlated significantly with a lower endometriosis likelihood even after adjusting for potential covariates, with the adjusted hazard ratio of 0.47 (95% confidence interval, 0.35–0.65). A longer duration of CHM use was associated with a reduction in endometriosis risk, especially in those using CHM for more than 730 days. Uses of several herbal products may be associated with a lower risk of endometriosis, like Ge-Gen, Da-Huang, Huang-Qin, Ye-Jiao-Teng, Chuan-Niu-Xi, Shu-Jing-Huo-Xue-Tang, Du-Huo-Ji-Sheng-Tang, Ge-Gen-Tang, Shao-Yao-Gan-Cao-Tang, Ping-Wei-San, Gan-Lu-Yin, and Dang-Gui-Nian-Tong-Tang. Conclusion Taken together, adding CHM to conventional therapy may reduce the incidence of endometriosis in women with RA. The therapeutic mechanisms and safety of these natural products may be a direction for future clinical studies.

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“…According to the protocol delineated by Vanlangenakke et al ( 2011 ), the cells were treated with 50 μl of CJ flower extract at varying concentrations (1, 5, 10, 50, and 100 μg/ml) alongside 50 μl of H 2 O 2 (250 μM) for a 24-h duration. Subsequently, cell viability was assessed using the MTT assay, and the cell viability was calculated based on the absorbance, as outlined by Lai et al ( 2018 ). The experiment was performed in triplicate.…”

Section: Methodsmentioning

confidence: 99%

Exploring the potential of Crotalaria juncea flower extracts as a source of antioxidants, antimicrobials, and cytoprotective agents for biomedical applications

Mahasawat,

Boukaew,

Prasertsan

2023

bta

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Plants provide an unlimited source of bioactive compounds, possessing tremendous applications in the pharmaceutical industry. In the search for sources of antioxidants and antimicrobial agents against human pathogens, ethanol extracts of Crotalaria juncea flowers (CJ flower extract) were evaluated. The highest total phenolic (5.65 μg GAE/ml) and flavonoid (0.43 μg QE/ml) contents were observed in the 100 μg/ml CJ flower extract. To assess antioxidant activity, three in vitro antioxidant tests were employed: DPPH radical-scavenging, ABTS + radical-scavenging, and hydroxyl radical-scavenging assay. The CJ flower extract demonstrated significant (P < 0.05) antioxidant activity, dependent on the percentage of solvent extraction and the specific assays utilized. The highest antioxidant activity was obtained with 100% ethanol extraction and using the hydroxyl radical-scavenging assay (56.63%). Antimicrobial activity was assessed against six human pathogens, including the fungi Microsporum gypseum and five Gram-positive bacteria (Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and Streptococcus mutans), as well as one Gram-negative bacterium (Escherichia coli ). The CJ flower extract inhibited the growth of both fungal and bacterial pathogens.The cytotoxicity of the CJ flower extract was measured using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the highest concentration of the extract (100 μg/ml) did not affect L929 cell viability. Moreover, the CJ flower extract demonstrated the ability to suppress H 2 O 2 -induced toxicity in L929 cells. Overall, the CJ flower extract has potential as an alternative source for exploring new antioxidants, antimicrobial agents, and cytoprotectants that could prove valuable for biomedical applications.

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Paeoniflorin Antagonizes TNF-α-Induced L929 Fibroblastoma Cells Apoptosis by Inhibiting NF-κBp65 Activation

Cited by 10 publications

References 23 publications

Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients

Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients

The Prescription of Chinese Herbal Medicine and Risk of Endometriosis in Women with Rheumatoid Arthritis: A Population-Based Cohort Study

Exploring the potential of Crotalaria juncea flower extracts as a source of antioxidants, antimicrobials, and cytoprotective agents for biomedical applications

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