Paeoniflorin prevents TLR2/4-mediated inflammation in type 2 diabetic nephropathy

Zhang, Tingmin; Zhu, Qi-Jin; Shao, Yunxia; Wang, Kun; Wu, Yuangang

doi:10.5582/bst.2017.01104

Cited by 47 publications

(39 citation statements)

References 26 publications

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“…(Wang et al, 2017). On the other hand, PAE reduced macrophage activation by inhibiting TLR2/4 signaling expression in type 2 diabetic nephropathy (Zhang et al, 2017). The examined dosage of HSYA and PAE at 13.7 and 26.7 µg/ml respectively were equivalent to their concentrations in XBJ (10 µl/ml).…”

Section: Xbj Has Better Anti-inflammatory Effect Than Its Main Componmentioning

confidence: 88%

Xuebijing Injection Alleviates Pam3CSK4-Induced Inflammatory Response and Protects Mice From Sepsis Caused by Methicillin-Resistant Staphylococcus aureus

Qian

Miao

et al. 2020

Front. Pharmacol.

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A leading cause of death worldwide is sepsis that develops as a dysregulated immune response to infection. Serious infection caused by methicillin-resistant Staphylococcus aureus (MRSA) increases the difficulty of treatment in septic patients. Host-directed therapy (HDT) is an emerging approach to bacterial infections. Xuebijing injection (XBJ), a commercialized injectable prescription from traditional Chinese medicine, has been used as adjuvant therapy for sepsis with a history of 15 years. Whether it plays a protective role in severe infection caused by antibiotic-resistant bacteria is still unknown. In this study, XBJ significantly improved the survival of MRSA-induced sepsis mice. In MRSA-infected mouse model, XBJ down-regulated the expression of inflammatory cytokines interleukin (IL)-6, tumor necrosis factor (TNF)-a, MCP-1, MIP-2, and IL-10 in sera. Besides that, it decreased the bacterial load in spleens, livers, and alleviated tissue damage of lung, liver, and kidney. The combination of XBJ with vancomycin or dexamethasone exhibited a better down-regulatory role of the inflammatory response. Then, the protective mechanism of XBJ was further investigated. XBJ inhibited heatkilled MRSA-induced IL-6 and TNF-a production in mouse macrophages. XBJ also decreased Pam3CSK4 (a synthetic tripalmitoylated lipopeptide mimicking bacterial lipoproteins)stimulated expression of IL-6, TNF-a, IL-1b, IL-12, etc. in mouse macrophages. Furthermore, XBJ down-regulated the activation of NF-kB, MAPK, and PI3K/Akt pathways in Pam3CSK4-stimulated mouse macrophages. In conclusion, our findings demonstrated that XBJ played a protective role in MRSA-challenged mice and down-regulated the inflammatory response and the activation of signaling pathways initiated by Pam3CSK4. It enlarged the clinical application of XBJ in the treatment of severe bacterial infection, e.g. caused by MRSA.

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Section: Xbj Has Better Anti-inflammatory Effect Than Its Main Componmentioning

confidence: 88%

Xuebijing Injection Alleviates Pam3CSK4-Induced Inflammatory Response and Protects Mice From Sepsis Caused by Methicillin-Resistant Staphylococcus aureus

Qian

Miao

et al. 2020

Front. Pharmacol.

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“…Paeoniflorin is one of the major active ingredients in Chinese peony, which is also called Paeonia lactiflora. Paeoniflorin is shown to have anti-inflammatory and immune-regulatory effects (Zhang et al, 2017; Chen et al, 2018). The latest study indicates that paeoniflorin can improve the IgE-induced allergic reaction and scratching behavior (Lee et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Integration of Metabolomics and Transcriptomics Reveals the Therapeutic Mechanism Underlying Paeoniflorin for the Treatment of Allergic Asthma

et al. 2019

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Objectives: Asthma is a chronic airway inflammatory disease, which is characterized by airway remodeling, hyperreactivity and shortness of breath. Paeoniflorin is one of the major active ingredients in Chinese peony, which exerts anti-inflammatory and immune-regulatory effects in multiple diseases. However, it remains unclear whether paeoniflorin treatment can suppress allergic asthma.Methods: In this study, we evaluated the effect of paeoniflorin on lung function and airway inflammation in asthmatic mice. These asthmatic Balb/c mice were first sensitized and constructed through ovalbumin (OVA) motivation. Subsequently, we determined the mechanism of action of paeoniflorin in treating allergic asthma through integrated transcriptomic and metabolomic data sets.Results: Our results demonstrated that many genes and metabolites were regulated in the paeoniflorin-treated mice. Moreover, the potential target proteins of paeoniflorin played important roles in fatty acid metabolism, inflammatory response, oxidative stress and local adhesion.Conclusion: Paeoniflorin has a beneficial effect on asthma, which may be achieved through regulating fatty acid metabolism, inflammatory response and the adhesion pathway at system level.

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“…Natural products and their extracts regards as a very large treasure now used for drug development.Paeoni orin,a natural product of polyphenols,has shown anticancer activity in a variety of cancers, [1]Paeoni orin exists in the roots of Paeonia genus plants such as Ranunculaceae,Peony,Purple Peony,etc, [2,3]and have been shown to have a wide range of treatments in nasopharyngeal cancer, [4]nonsmall cell lung cancer; [5,6]glioma, [7][8][9]diabetic nephropathy [10,11] and other diseases.Pharmacological activity,and especially anti-in ammatory effects, have been demonstrated in a variety of tumors or consumptive disease.The above results showed that paeoni orin could be used as a therapeutic agent for various diseases.In addition, [7,8,12]our previous studies had shown that paeoni orin could inhibited the migration,invasion,proliferation,and cell cycle of glioma cells.And in the veri cation of subsequent in vitro experiments,it also has the effect of inhibiting tumor growth.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Paeoniflorin Treatment of Cancer Based on Bioinformatic Network and Potential Target Prediction

yongan¹,

Yu²,

Li³

et al. 2020

Preprint

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In the synthesis of chemical drugs used to treat various cancers and tumors,more and more scientists are now focusing on the development of natural extracts.Paeoniflorin,as an important compounds of the total glucosides of peony,,had therapeutic effects on a variety of cancers in vivo and in vitro experiments.The purpose of this study was to use biological information analysis to reveal the basic mechanism and potential molecular mechanism of paeoniflorin treatment.We evaluated the efficacy of paeoniflorin through Traditional Chinese Medicine Systems Pharmacology Database(TCMSP).The potential targets of paeoniflorin were identified and summarized by Comparative Toxicogenomics Database (CTD),and GeneMANIA protein interaction analysis was performed online.Also.We used WebGestalt for Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis and functional annotation.Finally,cytoscape was used to construct the paeoniflorin-target-pathway network to predict the results.

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Paeoniflorin prevents TLR2/4-mediated inflammation in type 2 diabetic nephropathy

Cited by 47 publications

References 26 publications

Xuebijing Injection Alleviates Pam3CSK4-Induced Inflammatory Response and Protects Mice From Sepsis Caused by Methicillin-Resistant Staphylococcus aureus

Xuebijing Injection Alleviates Pam3CSK4-Induced Inflammatory Response and Protects Mice From Sepsis Caused by Methicillin-Resistant Staphylococcus aureus

Integration of Metabolomics and Transcriptomics Reveals the Therapeutic Mechanism Underlying Paeoniflorin for the Treatment of Allergic Asthma

Analysis of Paeoniflorin Treatment of Cancer Based on Bioinformatic Network and Potential Target Prediction

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