Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease

“…Behavioral deficits following administration of galactose, a neurotoxic agent, have been reversed (Zhong et al, 2009) and paeonol can prevent anoxic damage to nervous tissue (Hsieh et al, 2006;Wu et al, 2008). While in our study, paeonol appeared to mitigate Aβ-induced damage to the cerebral vasculature, paeonol has been reported as antiangiogenic in a trial relating to its potential use in cancer treatment ).…”

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

“…Earlier reports have shown that D-galactose can induce neurodegeneration in hippocampus (Zhong et al 2009;Banji et al 2013). In this current study with D-galactose treatment, we observed the loss of neurons and significant neuronal damage in the hippocampus of mice.…”

Nephroprotective activity ofMacrothelypteris oligophlebiarhizomes ethanol extract

“…The obtained homogenate was centrifuged at 800 rpm formitochondrial supernatant, which was used to determine the superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), nitric oxide (NO) and glutathione peroxidase (GSH-Px) (Paglia & Valentine, 1967;Marklund & Marklund, 1974;Zhong et al, 2009;Mohan et al, 2010;Koppula & Choi., 2011). Protein concentrations in tissue homogenates were determined by the method described previously using bovine serum albumin as the standard (Bradford, 1976).…”