PAF and Antigen-Induced Bronchial Hyperreactivity in Guinea Pigs

Temporal relationships between leukocytes, IL-5 and IL-8 in guinea pig lungs, plasma cortisol and airway function after antigen challenge

“…The cell adhesion molecules CD18, that binds ICAM-1, and the b1 integrin VLA-4, have been implicated in the antigen-induced pulmonary eosinophilia and hyperreactivity in guinea-pigs [14][15][16] and rabbits [23] by using a variety of neutralising monoclonal antibodies. Clearly many of the strategies which attenuate the antigeninduced eosinophilia also attenuate the development of the hyperreactive state [8][9][10][11][12][13][14][15][16] which would appear to support the theory of 'eosinophil-induced' hyperreactivity [1].…”

“…The guinea pig is widely used to model asthmatic responses in vivo [1]. Administering inhaled antigen to the sensitised animal can lead to the development of a number of features in common with bronchial asthma including: early and late phase bronchoconstrictor responses, inflammatory cell recruitment and the development of airway hyperreactivity [2][3][4][5][6][7].…”