Paget disease of bone in an elderly patient with chronic renal disease and weight loss

Abstract

Rationale:Asymptomatic Paget disease of bone (PDB) is mostly diagnosed by accidental finding of osteolytic lesion on the plain film. However, in elderly patient with chronic renal insufficiency and weight loss, it is crucial to differentiate PDB from metabolic and metastatic bone diseases for further treatment and better outcome.Patient concerns:An 80-year-old man with chronic kidney disease presented to our emergency department due to fever with chillness for a day, while the abdominal fullness, anorexia, and weight loss had been noted for 3 months. Mixed osteoblastic and lytic changes in the pelvic bone were accidentally found on the abdominal plain film.Diagnosis:The patient was diagnosed as asymptomatic PDB and urinary tract infection of Pseudomonas aeruginosa.Interventions and outcome:The patient received 7 days intravenous and followed by 7 days oral antibiotic treatment, which lead to clinical improvement of his urinary tract infection. No pharmacological treatment was initiated for the asymptomatic and localized PDB. The patient was discharged under stable condition afterward.Lessons:In patients with mixed osteolytic and blastic lesions, the differential diagnoses include metabolic and metastatic bone disease. Thorough understanding of the morphology of the bone lesions in high risk patient, not only helps to make differential diagnosis, but it also leads to precise treatment and better outcome.

Paget's disease of bone and megaloblastic anemia in a 72‑year‑old patient: A case report and systematic literature review

“…Case reports of PDB in the literature have presented other associated pathologies (16,(26)(27)(28), including vitiligo, chronic kidney disease (29), rheumatoid arthritis ( 16), tumor and tumor-like conditions; specifically, <5% of patients with PDB will undergo malignant transformation to sarcoma (30), but more extensive disease and a more prolonged course are associated with higher risk of eventually developing a sarcoma (31) (Fig. 7).…”