Paget Disease of the Breast: Mammographic, US, and MR Imaging Findings with Pathologic Correlation

Lim, Hyo Soon; Jeong, Su Jin; Lee, Ji Shin; Park, Min Ho; Kim, Jin Woong; Shin, Sang Soo; Park, Jin Gyoon; Kang, Heoung Keun

doi:10.1148/rg.317115070

Cited by 93 publications

(117 citation statements)

References 36 publications

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“…Несмотря на значительный прирост числа вновь выявленных случаев рака МЖ, статистика по РП остается стабильной -0,5-5,0 % от общего числа за-болевших в мире [7][8][9]. Болеют женщины 24-90 лет (средний возраст 50-60 лет) [10,11], преимущественно менопаузального возраста (70 %), хотя выявлены слу-чаи РП и у подростков [12].…”

Section: эпидемиология рака педжетаunclassified

“…В ней пред-полагается малигнизация или дегенерация уже суще-ствующих клеток, а клетки Педжета определяются как злокачественные кератиноциты, возникающие in situ [7][8][9]17].…”

Section: патогенезunclassified

“…Маммографическая оценка должна включать медио-латеральную и краниокаудальную проекции. На сним-ках обращают внимание на утолщение, втяжение или уплощение соска и ареолы, которые лучше всего отображаются при цифровой маммографии [8]. Так, например, на рис.…”

Section: диагностикаunclassified

“…В то же время не исключено отсутствие ка-ких-либо изменений на маммографических снимках (22-71 % больных) [8,41,31], и маммография может серьезно недооценивать степень болезни [45,46]. Ультразвуковое исследование не является вы-сокоточным методом для постановки диагноза РП.…”

Section: диагностика обзорные статьиunclassified

“…Чем выше чувствительность магнитно-резонансного сигнала в области соска, тем выше ве-роятность распространения рака по протокам МЖ [8,45,46]. Характерными признаками являются асимме-тричная форма, утолщение, уплощение или втяжение соска, а также асимметричный и повышенный маг-нитно-резонансный сигнал в этой области (рис.…”

Section: диагностика обзорные статьиunclassified

See 4 more Smart Citations

Paget’s disease of the breast (a review of literature)

Никитина¹,

Нечушкин²,

Trigolosov³

et al. 2016

Tumors of female reproductive system

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Section: эпидемиология рака педжетаunclassified

Section: патогенезunclassified

Section: диагностикаunclassified

Section: диагностика обзорные статьиunclassified

See 3 more Smart Citations

Paget’s disease of the breast (a review of literature)

Никитина¹,

Нечушкин²,

Trigolosov³

et al. 2016

Tumors of female reproductive system

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Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database

Chen

Yuan

et al. 2019

Cancer Medicine

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Background Most mammary Paget disease (MPD) is associated with underlying in situ or invasive breast cancer. The objective of this study was to compare the clinicopathological characteristics and survival outcomes between breast cancer with Paget disease (PD) and breast cancer alone. Methods From the Surveillance, Epidemiology, and End Results (SEER) database, 2000‐2015, of the US National Cancer Institute, we identified 1569 women who had PD with invasive ductal carcinoma (PD‐IDC) and 1489 women who had PD with ductal carcinoma in situ (PD‐DCIS). Independent demographic and clinicopathological variables as well as survival outcomes of these patients were compared to patients with the corresponding breast cancer without concomitant PD. Results PD‐IDC and PD‐DCIS both had worse survival outcomes and poorer tumor characteristics than the corresponding disease without PD. Contrary to in the breast cancer alone groups, in the breast cancer with PD groups, the HR status ( P = 0.182 in PD‐IDC and P = 0.371 in PD‐DCIS), HER2 status ( P = 0.788 in PD‐IDC and P = 0.643 in PD‐DCIS), and combined molecular subtype ( P = 0.196 in PD‐IDC and P = 0.853 in PD‐DCIS) were not found to affect disease prognosis. After matching tumor characteristics and treatment approaches, PD‐IDC as well as PD‐DCIS exhibited no significant difference in disease prognosis with corresponding IDC and DCIS. Finally, by comparative analysis, a kind of PD‐DCIS (ICD‐O‐3 code 8543/3) showed many invasive behaviors (31.8% of 8543/3 patients had stage I‐III cancer) and was associated with worse survival outcomes than the other type of PD‐DCIS. Conclusions Breast cancer with concomitant PD was associated with more aggressive tumor characteristics and worse survival outcomes. The HR status, HER2 status, and combined molecular subtype could not affect the prognosis of breast cancer with PD. Moreover, a portion of the PD‐DCIS cases were invasive breast cancer cases that required special treatment.

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Using immunohistochemistry to classify the molecular subtypes of Paget's disease of the breast

et al. 2023

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Purpose To classify the molecular subtypes of Paget's disease of the breast, and then compare them with general breast cancer to get deeper understanding of this disease and offer better management of associate patients in clinical decisions. Methods We used immunohistochemistry to examine 42 cases of this disease by antibodies against estrogen and progesterone receptors, Ki‐67, as well as human epidermal growth factor receptor 2 (HER‐2). Due to damage and loss of specimens, etc., we obtained 36 pathological specimens from the 42 patients. For 30 of 36 pathological specimens (83.3%), we obtained a complete molecular subtype. Cause the other 6 pathological specimens have missing immunohistochemistry items. For patients with bilateral breast cancer, only information on the side with PDB is listed. For patients with recurrence, only information on the first onset was included. We finally compared and studied the molecular subtype of 26 samples. We calculated the relative frequencies of molecular subtypes including luminal A, luminal B, HER‐2‐enriched, and basal‐like and compared them between PDB and general breast carcinomas in other studies. Results The luminal A and B subtype were found, respectively, in 3 (11.5%) and 6 (23.1%) of all patients, and 15 cases of HER‐2‐enriched subtype was detected (57.7%). In addition, 2 (7.7%) showed a basal‐like subtype. Conclusion The molecular subtypes of common breast cancer and PDB‐associated breast cancer differ. Luminal subtypes are the most common in the former, while within our samples HER‐2 positive subtype was the highest in PDB‐associated breast carcinoma. With further understanding of this disease, rational therapies will be applied in different patients and cures for PDB and PDB‐associated carcinoma will be achieved.

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Paget Disease of the Breast: Mammographic, US, and MR Imaging Findings with Pathologic Correlation

Cited by 93 publications

References 36 publications

Paget’s disease of the breast (a review of literature)

Paget’s disease of the breast (a review of literature)

Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database

Using immunohistochemistry to classify the molecular subtypes of Paget's disease of the breast

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