Paget disease of the breast: Changing patterns of incidence, clinical presentation, and treatment in the U.S.

Chen, Chin-Yau; Sun, Li‐Min; Anderson, Benjamin O.

doi:10.1002/cncr.22137

Cited by 142 publications

(104 citation statements)

References 105 publications

(153 reference statements)

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“…In our proposition we extend the representation of individual pixel to the region around it, including N neighboring pixels. In the case of RGB image each pixel will be represented by the vector of the length 3N, x=[R 0 , R 1 , …, R N , G 0 , G 1 This vector represents pixels of the image region denoted in the matrix form by bold. To prepare vector representation for the boundary pixels (for example position (1,1)) we extend the image by replicating the neighboring n columns and n rows in vertical and horizontal fashion.…”

Section: Methodsmentioning

confidence: 99%

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Milk duct segmentation in microscopic HE images of breast cancer tissues

et al. 2017

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Abstract. The aim of the paper is to recognize and extract the milk duct in haematoxylin and eosin (HE) stained breast cancer tissues. The paper presents the modified K-means approach to segmentation of the milk duct in HE stained images. Instead of using single pixels we propose to consider the defined region of pixels in the process. Thanks to such modification more accurate extraction of the milk ducts has been achieved. To compare the results in a numerical way the GT images prepared by the medical expert have been subtracted from the corresponding images created by the segmentation methods. The numerical experiments performed for many preparations have confirmed the superiority of such approach. The proposed method has allowed reducing significantly the error of duct segmentation in comparison to the classical K-means approaches. The results show, that our method is superior to the standard K-means and to the K-means preceded by averaging or Gaussian filtration at different size of filtration mask.

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Section: Methodsmentioning

confidence: 99%

“…Ductal carcinoma in situ (DCiS) belongs to the most frequently appearing type of non-invasive breast cancer [1,2]. It is "non-invasive" because is limited to the milk duct and is regarded as not life-threatening.…”

Section: Introduction -Medical Backgroundmentioning

confidence: 99%

Milk duct segmentation in microscopic HE images of breast cancer tissues

et al. 2017

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“…Paget's disease of the breast represents approximately 1-3% of all breast malignancies (1,2) and is characterized pathologically by the presence of round intraepidermal cells of the nipple. Paget's disease can present in conjunction with an underlying invasive cancer, in conjunction with underlying ductal carcinoma in situ (DCIS), or alone without any underlying invasive breast carcinoma or DCIS (3). The majority of cases of Paget's disease have an underlying breast malignancy (1,2); however, 66-86% of patients without a clinical mass on physical examination or mammogram have DCIS alone.…”

Section: Introductionmentioning

confidence: 99%

“…The majority of cases of Paget's disease have an underlying breast malignancy (1,2); however, 66-86% of patients without a clinical mass on physical examination or mammogram have DCIS alone. Early reports described the occurrence of Paget's disease alone without an underlying cancer as rare, representing at most 8% of patients with Paget's disease (3). The prognosis of patients who present with Paget's disease of the breast is primarily determined by the extent of the associated carcinoma (1,2), and adjuvant treatment is administered depending on nodal and receptor status.…”

Section: Introductionmentioning

confidence: 99%

Synchronous bilateral Paget’s disease of the breast: A case report

Xie¹,

Zheng²,

Lan³

et al. 2012

Oncology Letters

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Abstract. Synchronous bilateral Paget's disease of the nipple is extremely rare. In the present study, we report a case of synchronous bilateral Paget's disease in a 45-year-old woman who had a medical history of gastric cancer. The patient presented with a 6-month history of eczema and itching in both nipples. Mammography and ultrasonography did not reveal any mass lesions in the bilateral breast, and computed tomography and bone scintigraphy showed no site of distant metastasis. The patient was scheduled for mastectomy and sentinel node biopsy. The histological diagnosis was Paget's disease of the breast with no evidence of underlying invasive ductal carcinoma or ductal carcinoma in situ of the breast tissue. There was no metastasis in either of the sentinel nodes. Immunohistochemical staining showed a negative expression of oestrogen and progesterone receptors. The patient has not received chemotherapy, radiotherapy or hormonal therapy. The patient has been disease-free for 7 months following surgery.

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“…About half of cases of Paget disease are due to DCIS alone and the remainder to DCIS associated with an invasive carcinoma located deeper in the breast. 4 It is very unusual for Paget cells in the skin to directly invade the dermis. To our knowledge, only 2 patients have been described in previous case reports.…”

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confidence: 99%

Paget Disease of the Breast With Invasion From Nipple Skin Into the Dermis: An Unusual Type of Skin Invasion Not Associated With an Adverse Outcome

Sanders

Dominici

Denison

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Paget disease is an uncommon skin manifestation of breast cancer, associated with either invasive carcinoma or ductal carcinoma in situ in the underlying breast. In very rare cases, tumor cells within the epidermis invade through the basement membrane of the skin into the dermis. Objectives.—To identify a series of cases of Paget disease with direct dermal invasion and to investigate the clinicopathologic features and outcome. Design.—Cases were identified during a 6-year period from the files of 2 hospitals. The clinical histories, imaging studies, and pathology reports were reviewed. Results.—Seven patients were identified, 5 with microinvasion (<0.1 cm) and 2 with 0.2- or 0.3-cm invasive carcinomas in the dermis. No lymphovascular invasion was seen. Sentinel nodes were negative in 3 patients who underwent biopsy. Five patients were treated with breast conservation with radiation. Three patients were at high risk for breast cancer because of prior breast cancer, Li-Fraumeni syndrome, or radiation for Hodgkin disease. The latter 2 patients underwent bilateral mastectomies. Three patients received hormonal therapy and 1 oophorectomy. No patient received chemotherapy. At follow-ups ranging from 4 to 66 months (median, 20 months), there have been no recurrences. Conclusions.—Patients with direct dermal invasion from Paget disease had a favorable outcome during the available follow-up period. This type of dermal involvement must be distinguished from locally advanced invasive carcinomas with skin invasion classified as T4b in the American Joint Cancer Commission staging system, as cancers with other types of skin invasion are associated with a poor prognosis.

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Paget disease of the breast: Changing patterns of incidence, clinical presentation, and treatment in the U.S.

Cited by 142 publications

References 105 publications

Milk duct segmentation in microscopic HE images of breast cancer tissues

Milk duct segmentation in microscopic HE images of breast cancer tissues

Synchronous bilateral Paget’s disease of the breast: A case report

Paget Disease of the Breast With Invasion From Nipple Skin Into the Dermis: An Unusual Type of Skin Invasion Not Associated With an Adverse Outcome

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