Paget's Disease of Bone

Collins, D. H.

doi:10.1016/s0140-6736(56)90422-6

Cited by 261 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is a focal skeletal disorder characterized by an accelerated bone turnover 210. The incidence of Paget disease is difficult to estimate because most patients are asymptomatic 1–310.…”

Section: Discussionmentioning

confidence: 99%

Paget disease of the bone: Does it exist in Saudi Arabia?

Alshaikh

Almanea

Alzahrani

2011

Annals of Saudi Medicine

View full text Add to dashboard Cite

Paget disease of the bone is a chronic disease characterized by accelerated bone turnover with abnormal repair leading to expansion, pain and deformities. The disease is common in the West, but little if any information is available on its existence in the Arab world, including Saudi Arabia. We present four cases of Saudi patients with Paget disease with variable presentations. The first case, a 63-year-old woman with a history of papillary thyroid cancer, presented with bone, shoulder and chest wall pain and foci of uptake in the ribs and skull that were thought to be metastases, indicating the possibility of diagnostic difficulty in a patient with history of malignancy. Bone biopsy confirmed the diagnosis of Paget disease. The second case was a 47-year-old asymptomatic woman with an elevated alkaline phosphatase of 427 U/L, a common presentation but at an unusual age. Plain x-rays and bone scan confirmed the diagnosis. The third case was a 43-year-old man who presented with hearing impairment and right knee osteoarthritis, unusual presentations at a young age leading to a delay in diagnosis. The fourth case was a 45-year-old man who presented with sacroiliac pain and normal biochemical values, including a normal alkaline phosphatase. Bone biopsy unexpectedly revealed features of Paget disease, which evolved over time into a classical form. A common feature in all except the first case was the relatively young age. Paget disease does exist in Saudi Arabia, and it should be considered in the differential diagnosis of similar cases.

show abstract

“…It is a focal skeletal disorder characterized by an accelerated bone turnover 210. The incidence of Paget disease is difficult to estimate because most patients are asymptomatic 1–310.…”

Section: Discussionmentioning

confidence: 99%

Paget disease of the bone: Does it exist in Saudi Arabia?

Alshaikh

Almanea

Alzahrani

2011

Annals of Saudi Medicine

View full text Add to dashboard Cite

show abstract

“…Price and Goldie [1] estimated the prevalence of Paget's sarcoma of all types amongst the populations of the Leeds and Bristol regions with almost identical results. Thus it may be assumed that a similar proportion of the population of the Bristol region also may have Paget's disease.…”

mentioning

confidence: 90%

“…Collins [1] in a careful study of 650 autopsies at Leeds and Sheffield found evidence of Paget's disease in 3.7% of cadavers over 40 years of age-equivalent to 1.6% of an English population of all ages. Price and Goldie [1] estimated the prevalence of Paget's sarcoma of all types amongst the populations of the Leeds and Bristol regions with almost identical results.…”

mentioning

confidence: 99%

Myeloma occurring with Paget's disease of bone

Price

1976

Skeletal Radiol.

View full text Add to dashboard Cite

show abstract

“…Involvement of a single bone or a single focus of osteitis deformans was noted in 40 %, a higher incidence for the monostotic (mono-osteitic) form of Paget's disease than reported previously. The mono-osteitic type was not described till 1924 [N e w t o n ] and Collins [1956] gave its incidence as 10% which included cases of osteoporosis circumscripta of the skull. Sixty percent of our patients had two or more bones in volved (table IV).…”

Section: Bone Involvementmentioning

confidence: 99%

“…M ercer and D uthif. [1955] found this potentially serious complications in 20 % of their cases of Paget's disease, whereas Collins [1956] reported only 13 %. As a rule fractures occur during the active phase of Paget's disease when bony rarefaction is present.…”

Section: Fracturesmentioning

confidence: 99%