Paget's disease of jaw bones as primary manifestation: A case report of a proper diagnosis made by general dentist

Campolongo, Martin Giorgio; Cabras, Marco; Bava, Luca; Arduino, Paolo Giacomo; Carbone, M

doi:10.1111/ger.12328

Cited by 3 publications

(7 citation statements)

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“…Simple bone cyst (SBC) were found in three cases (4.1%). SBC was observed mainly in male patients (2 cases; 66.6%) and in one case, the sex was not reported; the mean age was 15 years (range: [13][14][15][16][17][18][19]. In two cases, the diagnostic criteria were CE, PR, and CT (66.6%).…”

Section: Resultsmentioning

confidence: 97%

“…The two cases had two affected quadrants. Langerhans cell histiocytosis (LCH) corresponded to 2 cases (2.7) in males at a mean age of 14.5 years (range: [11][12][13][14][15][16][17][18]. Under the main diagnostic criteria, CE, PR, and biopsy were performed in both cases (100%) and both cases presented an ill-defined, radiolucent image, and had four affected quadrants.…”

Section: Resultsmentioning

confidence: 99%

“…12 PD presents, in general, in polyostotic form involving many skeletal bones, with jawbones being involved in 15% of cases (Figure 2A-C). 13 The upper jaw is more affected than the lower jaw. In the early phase (osteolytic phase), radiolucent areas predominate (ground glass appearance), leading to the loss of the lamina dura when the lesion involves migration and resorption of the roots of teeth.…”

Section: Discussionmentioning

confidence: 99%

“…14 Bone scintigraphy (Figure 2D-H) is recommended to delineate the alteration of mandible bone (Lincoln`s sign). 13 Osteopetrosis is an inherited metabolic bone disorder with a clinical spectrum ranging from mild to severe that shows uniform and generalized sclerosis of the skeleton due to a failure in bone resorption (impaired osteoclast activity or development). Parallel bands of dense bone in the vertebrae and long bones give the impression of 'bone-withinbone'.…”

Section: Discussionmentioning

confidence: 99%

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Synchronous jawbone diseases: a multicenter retrospective study

et al. 2023

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The aim of this study is to report an original case series of synchronous jawbone diseases. Data of patients seen over 13 years were extracted from the files of three Oral Radiology and Pathology diagnostic centers in Brazil. The clinical, radiographic, and laboratory characteristics were tabulated and analyzed by the authors; the patients were described according to lesion type. Seventy-two synchronous jawbone diseases were included in this study. Florid osseous dysplasia, Gorlin-Goltz syndrome, and cherubism were the most frequent disorders reported in this case series. In addition, the posterior mandible area was the main site of manifestation. Florid osseous dysplasia and Gorlin-Goltz syndrome represented two-thirds of our samples. With the utilization of adequate demographic, clinical, and radiologic information, it is possible to diagnose most of the synchronous lesions of jawbones. Sometimes, however, we need complementary exams, such as histopathologic and biochemical analysis or dosing of calcium, phosphorus, and alkaline phosphatase.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Synchronous jawbone diseases: a multicenter retrospective study

et al. 2023

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“…PD presents, in general, in polyostotic form involving many bones of skeletal, with jawbones being involved in 15% of cases (Figure 3A-3C) 13 . The upper jaw is more affected than the lower jaw.…”

Section: Discussionmentioning

confidence: 99%

Lesões sincrônicas dos maxilares

dos Santos da Mata Rezende

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A Ata da defesa, assinada pelos membros da Comissão Examinadora, consta no SIGA/Sistema de Fluxo de Dissertação/Tese e na Secretaria do Programa da Unidade. DEDICATÓRIAEste trabalho é integralmente dedicado ao Prof. Dr. Helder Antonio Rebêlo Pontes. Seu apoio incondicional, nos momentos difíceis desta trajetória, foi a mola propulsora que permitiu o meu avanço e sem o qual eu não teria concluído esta etapa acadêmica. Gratidão eterna. AGRADECIMENTOA Deus por ser autor do meu destino, Ele está sempre presente, me mostrando o caminho certo e proporcionando perseverança durante os momentos difíceis.Aos meus pais por terem me concedido a vida, por todo esforço investido na minha educação e pelo amor irrestrito.Ao Prof. Dr. Hélder Antônio Rebelo Pontes, pela orientação em mais essa etapa da minha formação profissional e pessoal. Além disso, muito obrigado pela paciência nos momentos em que fraquejei, sua amizade me guiou até aqui e sem ela eu não teria conseguido concluir este processo.Ao Dr. José Antônio Brito dos Santos (tio Zeca), uma pessoa admirável, da qual sou grato e me que orgulho em ter presente em minha vida. Ademais um profissional que me inspira a ser cada dia melhor.Aos meus irmãos, Maíra e Lucas, meus melhores amigos. Sou grato pelo companheirismo, pela cumplicidade e pelo apoio incondicional em todos os momentos da vida.As minhas afilhadas, Izabel e Ana Luísa, o amor que sinto por vocês é minha principal motivação.Ao Prof. Dr. Oslei Paes de Almeida pela amizade, acolhimento e pela troca experiências, em especial as vividas no quintal da sua casa.

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Beyond the mouth: Uncovering non-secretory multiple myeloma through oral symptoms

Isaias,

Costa,

Amorim

et al. 2024

Imaging Sci Dent

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Non-secretory multiple myeloma (NSMM) is a rare cancer of plasma cells characterized by the absence of detectable monoclonal M protein in the blood or urine. A 57-year-old woman presented with mandibular pain but without intraoral swelling. Imaging studies revealed multiple osteolytic lesions in her mandible and pronounced root resorption of the left mandibular second molar. Biopsy results showed atypical plasmacytoid cells positive for anti-kappa, CD138, MUM1, and CD79a antibodies, but negative for anti-lambda and CD20. These results were indicative of a malignant plasma cell neoplasm. No abnormalities were revealed by free light chain assay or by serum or urine protein electrophoresis, leading to a diagnosis of NSMM. The patient began chemotherapy in conjunction with bisphosphonate therapy and achieved remission following treatment. This case underscores the critical role of dentists in the early detection and prevention of NSMM complications, as the disease can initially present in the oral cavity.

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Paget's disease of jaw bones as primary manifestation: A case report of a proper diagnosis made by general dentist

Abstract: Clinicians should consider PDB in differential diagnosis for an elderly patient undergoing unexplained alteration in face profile and occlusion.

Cited by 3 publications

References 5 publications

Synchronous jawbone diseases: a multicenter retrospective study

Synchronous jawbone diseases: a multicenter retrospective study

Lesões sincrônicas dos maxilares

Beyond the mouth: Uncovering non-secretory multiple myeloma through oral symptoms

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