Paget's disease of the vulva

Tebes, Stephen J.; Cardosi, Richard J.; Hoffman, Mitchel S.

doi:10.1067/mob.2002.125700

Cited by 95 publications

(70 citation statements)

References 8 publications

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“…Combined with immunohistochemical techniques for tumor antigens can be detected by the presence of micrometastasis, to achieve tumor "super stage" [17]. The incidence of genital extramammary Paget's disease in this study is consistent with the literature [18]. The disease lesions confined to the epidermis had better prognosis [19].…”

Section: Lymph Node Status Totalsupporting

confidence: 81%

Clinical analysis of vulvar carcinoma

Thakur¹,

Nijamudin²,

Hua³

et al. 2013

Gynecol

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Objective: The purpose of this study is to understand the incidence, related factors, and the prognosis factors in order to avoid risk, proper method of diagnosis and treatment and reduce complications and provide the basis. Methods: 85 Vulvar cancer (VC) patients treated in our hospital from 2002.10 to 2012.10 were collected and analyzed by retrospective comparative methods. SPSS19.0 application software was used for the statistical analysis. The clinical data are analyzed by chi-square and F test statistic methods. P < 0.05 was a significant difference between the judgment standard. Results: During 10 years, we treated 3391 cases of the primary malignant tumors including 85 VC cases; VC was 2.89% (85/3391). The age was between 24~88 years old, mean was 57.09±12.93 yrs. old, variable age (F=6. 013, P=0.016<0.05). VC had seen more in rural than urban patients. By statistical analysis, region distribution in these two groups was remarkably different=4.16, P=0.045<0.05, but the urban proportion of patients in different years has no difference (χ2=0.080, P=0.777). Conclusion:The number of cases increased progressively in young age. VC patients were more in rural area than urban. High-risk groups Suggested doing regular physical exam. For long-term genital itching, genital tumor, genital ulcers, and other symptoms, should be alert to the possibility of VC. Preoperative diagnosis should be Colposcopic, biopsy in order to improve the accuracy of earlier diagnosis. Postoperative common complications are wound infection. Follow-up rate is low; It is difficult to say statistically survival rate is 5 years.

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Section: Lymph Node Status Totalsupporting

confidence: 81%

Clinical analysis of vulvar carcinoma

Thakur¹,

Nijamudin²,

Hua³

et al. 2013

Gynecol

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“…Therefore, a recurrence rate up to 30% after surgical therapy has been reported [88,89]. Invasive vulvar Paget's disease can be treated with radical vulvectomy and skin grafting [90].…”

Section: Tumours Other Than Squamous Cell Carcinomamentioning

confidence: 99%

Old and new perspectives in the management of high-risk, locally advanced or recurrent, and metastatic vulvar cancer

Gadducci

Cionini

Romanini

et al. 2006

Critical Reviews in Oncology/Hematology

104

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“…Paget cells are usually found in the adnexal strictures of the epidermis that may be located in the subcutaneous tissue. These adnexal structures are never found more than 0.5 cm below the dermis [3]. Therefore, an optimal therapy for vulvar EMPD is simple vulvectomy with a minimum of 0.5 cm of subcutaneous tissue.…”

Section: Discussionmentioning

confidence: 98%

Paget’s disease of the vulva with bladder invasion: a case report

Inoue

Shiina

Igawa

2011

Arch Gynecol Obstet

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Tumor excision and dermal-flap skin graft operations were performed on a 72-year-old woman diagnosed with extramammary Paget's disease at our hospital in August 2001. Paget cells were identified in the external urethral meatus even though nine local excisions of recurrent tumors had been performed. She was suffered from severe vesical pain from May 2007. Urine cytology was class V and physical examination revealed redness in external urethral meatus. Pelvic MRI did not show apparent lymph node swelling and the endoscopic multiple biopsies performed at multiple bladder mucosa and distal urethra. Pathological diagnosis of the endoscopic biopsy showed multiple Paget cells from urethra, posterior and bilateral lateral wall, and bladder neck. Because Paget's disease may infiltrate bladder mucosa and cause severe vesical pain due to bladder invasion, total cystorethrectomy, ileal conduit, and external skin excision were performed. Pathological findings were continuous infiltration of Paget cells from external urethral meatus to bladder mucosa.

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Paget's disease of the vulva

Cited by 95 publications

References 8 publications

Clinical analysis of vulvar carcinoma

Clinical analysis of vulvar carcinoma

Old and new perspectives in the management of high-risk, locally advanced or recurrent, and metastatic vulvar cancer

Paget’s disease of the vulva with bladder invasion: a case report

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