Pagetoid Bowen's disease of vulva: Excellent response to imiquimod

Vulvar Bowen disease treated successfully by Photodyamic therapy: about two cases

“…The therapeutic decision takes into account the size and number of lesions, and the age of the patient, but also the experience of the practitioner and the choice of the patient as well as his immune status. Although it has the advantage of histological control, surgery at the vulvar level can be debilitating and mutilating with severe consequences [4][5][6]. Dynamic phototherapy (PDT) is increasingly used to treat superficial cancers of the skin.…”

“…We specify that treatment with Imiquimod alone requires a more aggressive treatment, of prolonged duration and offers only partial results in the literature. However, in some report cases, Imiquimod allowed an interesting result in pagetoid form and small area [5,6]. For our extensive cases, we opted for a PDT with a supplement therapy by Imiquimod due to its immunomodulatory action to potentiate the effect of PDT and minimize the risk of recurrence.…”

“…Dynamic phototherapy (PDT) is an interesting therapeutic strategy thanks in particular to the original properties of tumor selectivity [3,4]. Also, Imiquimod can be a potential treatment modality for lesions that are difficult to treat with surgical excision [5,6].…”