Pagetoid spread to oral mucosa from submandibular gland salivary duct carcinoma: a case report

Undifferentiated Laryngeal Carcinoma with Pagetoid Spread

“…In the present laryngeal case, there was spread of the CK7 and CK19 positive tumor cells into the non neoplastic mucosa which was CK5/6 positive, sparing the basement membrane, creating a typical pagetoid pattern evidenced both by morphology and immunohistochemical staining. Pagetoid spread is a very rare entity in head and neck tumors and four cases were reported to the best of our knowledge [1][2][3][4], excluding the sebaceous carcinomas of the orbit and parotid gland [10]. Both the tumor type and the localization of present case seem to be different from the previous ones.…”

“…Immunohistochemistry is helpful as the malignant cells present different expression of antigens from the non-neoplastic epithelial cells [9]. ''Pagetoid spread'' is used to define intraepithelial spread of cancer cells, when a massive carcinoma is identified beneath the basal membrane [3][4][5][6][7]. In the present laryngeal case, there was spread of the CK7 and CK19 positive tumor cells into the non neoplastic mucosa which was CK5/6 positive, sparing the basement membrane, creating a typical pagetoid pattern evidenced both by morphology and immunohistochemical staining.…”

“…Of the three previously reported cases in the oral cavity, two cases were salivary duct carcinomas and one case was an adenocarcinoma [1][2][3]. Pagetoid spread was also described in a maxillary sinus salivary hybrid carcinoma with high-grade transformation [4].…”

“…Pagetoid spread was also described in a maxillary sinus salivary hybrid carcinoma with high-grade transformation [4]. Intraductal spread along the salivary gland duct was proposed as a mechanism of pagetoid spread for these tumors [2][3][4]. A nasal case with sebaceous carcinoma with pagetoid spread, originating from the nasolacrimal duct, was also described [5].…”

Dedifferentiated Salivary Hybrid Carcinoma of the Maxillary Sinus with Pagetoid Spread to the Overlying Lining Mucosa

“…Although dedifferentiation/high grade transformation has been described in a variety of malignant salivary gland tumors, this phenomenon has not been reported in salivary hybrid carcinoma [21,22]. Furthermore, while pagetoid spread of neoplastic cells from a malignant salivary gland tumor to the overlying lining mucosa has been documented in the oral mucosa [21][22][23], such an incidence has not been reported in the maxillary sinus. Herein, we describe an additional case of hybrid carcinoma of salivary glands in the maxillary sinus that demonstrated simultaneous occurrence of high-grade transformation and intraepithelial pagetoid spread to the overlying sinus mucosa.…”