"PAI mutation 4G/5G- Coagulopathy Risk Factor for Stroke or Multiple Sclerosis"

Abstract

Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) with difficult differential diagnosis. The new trials show the importance of PAI-1 in etiology of neuroinflammation and neurodegeneration in multiple sclerosis. PAI mutation of 4G/5G is a risk factor for thrombotic events in young adults. We present a prospective study with patient diagnosed with MS and examined for thrombophilia, especially PAI mutation 4G/5G. Observational study was performed to evaluate the incidence of PAI mutation in patients with ischemic stroke and healthy control group. A comparison analyses was done in the three groups of patients. PAI mutation could play a role as a risk factor for neuroinflammation in MS.