Pain and Morbidity of an Extensive Prostate 10-Biopsy Protocol: A Prospective Study in 289 Patients

Peyromaure, Michaël; Ravery, V.; Messas, A.; Toublanc, M.; Boccon-Gibod, L; Boccon-Gibod, L

doi:10.1016/s0022-5347(05)65416-x

Cited by 89 publications

(65 citation statements)

References 13 publications

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“…The scale has also been used in visually impaired patients and to evaluate pain intensity after surgery (12,13). A study assessing pain intensity after TRUS-GB reported a mean NRS score of 3.2 (9). This is consistent with our findings, while pain intensity for MRI-GB was lower.…”

Section: Discussionsupporting

confidence: 91%

“…In the literature the rate of hematuria after TRUS-GB is in the range of 11%-57%, while a higher rate (79%) of mostly mild hematuria was observed in our patient cohort (8,9,14).…”

Section: Discussioncontrasting

confidence: 53%

“…While several studies are available on the side effects, complications, and pain experienced by patients who undergo TRUS-GB, no study has been published on the acceptance and side effects of MRI-GB of the prostate (7)(8)(9). We therefore conducted a survey among patients who underwent MRI-GB of suspicious areas detected by MRI after a history of at least one negative TRUS-GB.…”

mentioning

confidence: 99%

See 2 more Smart Citations

MRI-guided core needle biopsy of the prostate: acceptance and side effects

Egbers¹,

Schwenke²,

Maxeiner³

et al. 2015

Diagn Interv Radiol

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Section: Discussionsupporting

confidence: 91%

“…In the literature the rate of hematuria after TRUS-GB is in the range of 11%-57%, while a higher rate (79%) of mostly mild hematuria was observed in our patient cohort (8,9,14).…”

Section: Discussioncontrasting

confidence: 53%

mentioning

confidence: 99%

See 1 more Smart Citation

MRI-guided core needle biopsy of the prostate: acceptance and side effects

Egbers¹,

Schwenke²,

Maxeiner³

et al. 2015

Diagn Interv Radiol

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“…[8] Hematuria is the most frequently seen complication following TRUS-guided prostate biopsy.Hematuria with an incidence ranging between 14.4, and 84%, persists for an average of 2.7-5.1 days which can extend up to 20 days. [5,7,[9][10][11][12][13][14][15][16][17][18][19][20][21] As a minor complication, hematuria which is frequently encountered after biopsy, generally lasts briefly without any need for additional treatment However, in 0.25-0.7% of the cases hematuria leading to clot retention and/or requiring transfusion can be seen. [5,13] Hematospermia which is another frequently seen complication has been reported in 5.7, and 89% of the cases.…”

Section: Discussionmentioning

confidence: 99%

Complications of transrectal ultrasound-guided 12-core prostate biopsy: a single center experience with 2049 patients

Efesoy¹,

Bozlu

Çayan

et al. 2013

Turkish Journal of Urology

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Objective: Currently, transrectal ultrasound-guided (TRUS) systematic prostate biopsy is the standard procedure in the diagnosis of prostate cancer. Although TRUS-guided prostate biopsy is a safe method, it is an invasive procedure that is not free from complications. In this prospective study we evaluated the complications of a TRUS-guided 12-core prostate biopsy. Material and methods:The study included 2049 patients undergoing transrectal ultrasound-guided 12-core prostate biopsy used in the diagnosis of prostate cancer. The indications for the prostate biopsy were abnormal digital rectal examination findings and/or an elevated serum total prostate specific antigen (PSA) level (greater than 4 ng/mL). The participants received prophylactic oral ciprofloxacin (500 mg) the night before and the morning of the biopsy, followed by 500 mg orally twice daily for 2 days. To prevent development of voiding disorders, the patients also received oral alpha blockers for 30 days starting the day before the procedure. A Fleet enema was self-administered the night before the procedure for rectal cleansing. The complications were assessed both 10 days and 1 month after the biopsy. Results:The mean age, serum total PSA level and prostate volume of the patients were 65.4±9.6 years, 18.6±22.4 ng/mL and 51.3±22.4 cc, respectively. From these 2.042 biopsies, 596 cases (29.1%) were histopathologically diagnosed as prostate adenocarcinoma. Minor complications, such as hematuria (66.3%), hematospermia (38.8%), rectal bleeding (28.4%), mild to moderate degrees of vasovagal episodes (7.7%), and genitourinary tract infection (6.1%) were noted frequently. Major complications were rare and included urosepsis (0.5%), rectal bleeding requiring intervention (0.3%), acute urinary retention (0.3%), hematuria necessitating transfusion (0.05%), Fournier's gangrene (0.05%), and myocardial infarction (0.05%).Conclusion: TRUS-guided prostate biopsy is safe for diagnosing prostate cancer with few major but frequent minor complications. However, patients should be informed and followed-up after biopsy regarding possible complications.

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“…However, increasing the number of biopsies does not seem to add to pain and anxiety from the procedure. 15 In this study, all patients underwent a standard six-sector biopsy.…”

Section: Relevance Of Study To Biopsy Protocolsmentioning

confidence: 99%

A randomised trial of periprostatic local anaesthetic for transrectal biopsy

Walsh

O’Brien

Salemmi

et al. 2003

Prostate Cancer Prostatic Dis

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Increasingly transrectal ultrasound and biopsy is performed for the detection of prostate cancer. We have conducted a randomised trial to evaluate whether the addition of periprostatic local anaesthetic injection reduces the discomfort of the procedure. A total of 64 patients who attended a specialised prostate clinic and were being evaluated for an elevated prostate-specific antigen agreed to participate in the trial and were randomly allocated to two groups. The intervention group received 10 ml of 1% lignocaine in the periprostatic tissue prior to biopsy and the control group underwent a standard biopsy. All patients had a sextant biopsy under ultrasound guidance. After the procedure, they were asked to determine the severity of the pain on a scale of 0-10 and the whether the quality of the pain was mild, moderate or severe. The responses were distributed normally. The groups were compared using Student's t-test. Pain severity showed no significant difference between the two groups (P ¼ 0.14). There was a trend towards a statistical difference (P ¼ 0.07) on the qualitative pain scale. In conclusion, no significant difference in overall discomfort in men having sextant biopsies was detected between the two groups, suggesting that the administration of local anaesthetic may not be as valuable as early reports have suggested.

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Pain and Morbidity of an Extensive Prostate 10-Biopsy Protocol: A Prospective Study in 289 Patients

Abstract: Although minor complications are common, the extensive 10-core prostate biopsy protocol is associated with few major complications. The occurrence and intensity of pain and discomfort are in the range reported after the standard 6-core biopsy protocol.

Cited by 89 publications

References 13 publications

MRI-guided core needle biopsy of the prostate: acceptance and side effects

MRI-guided core needle biopsy of the prostate: acceptance and side effects

Complications of transrectal ultrasound-guided 12-core prostate biopsy: a single center experience with 2049 patients

A randomised trial of periprostatic local anaesthetic for transrectal biopsy

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