Pain and Mortality Risk in a Cohort of HIV-Infected Persons with Alcohol Use Disorders

Abstract

Pain has been associated with increased risk for mortality in some studies. We analyzed data from a cohort study [HIV-longitudinal interrelationships of viruses and ethanol (HIV-LIVE)] of HIV-infected persons with alcohol use disorders enrolled 2001–2003 to explore whether reporting moderate or greater pain interference was associated with mortality. The main independent variable was pain that at least moderately interfered with work based on a single question from the SF-12. Primary analyses dichotomized at “moderately” or above. Cox proportional hazards models assessed the association between pain interference and death adjusting for demographics, substance use, CD4 count, HIV viral load and co-morbidities. Although significant in unadjusted models (HR = 1.58 (95 % CI 1.03–2.41; p value = 0.04)), after adjusting for confounders, ≥moderate pain interference was not associated with an increased risk of death [aHR = 1.30 (95 % CI 0.81–2.11, p value = 0.28)]. Among HIV-infected persons with alcohol use disorders, we did not detect a statistically significant independent association between pain interference and risk of death after adjustment for potential confounders.

Association between alcohol consumption trajectories and clinical profiles among women and men living with HIV

“…Heavy drinking in this population is also associated with engagement in risky health behavior, such as cigarette (18,19) and substance use (20), which can lead to other chronic illnesses. Some studies have found that PLWH who use alcohol have increased chronic comorbidity (5,10,21,22), while other studies have found no such association (3,23–25). Others have found a J-curve association between alcohol consumption and risk for chronic illness.…”

Studi Literatur Intensitas Nyeri Pada Orang Dengan HIV/AIDS

“…Faktor klinis berupa jumlah CD4, fase klinis dan pengobatan Anti-Retroviral (ARV) dan infeksi oportunistik merupakan salah satu faktor internal yang dialami seseorang. Dalam tiga penelitian yang dilakukan oleh Azagew, Woreta, Tilahun, dan Anlay (2017); Lawson et al (2015); dan Tsui et al (2016) jumlah CD4 yang lebih rendah tidak memiliki hubungan dengan adanya rasa sakit yang dialami oleh ODHA.…”

Factors associated with current and severe pain among people living with HIV: results from a statewide sample

“…In addition to chronic pain, PLHIV have also reported mental health and harmful substance use issues [ 6 , 8 ]. Generally, PLHIV experiencing mental health problems such as anxiety and depression are also more likely to report increases in pain [ 9 , 10 ].…”