Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats

Sieve, Amy N.; King, Tamara; Ferguson, Adam R.; Grau, James W.; Meagher, Mary W.

doi:10.1007/s002130000535

Cited by 10 publications

(1 citation statement)

References 63 publications

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“…This is especially important in the present case, because vocalization to shock can be elicited in decerebrate subjects that lack a forebrain and, presumably, experience no pain (King et al, 1999; Meagher, 1989). Given this limitation, in Experiments 3 and 4 we examined the effect of severe shock using behavioral assays (vocalization to heat and fear conditioning) that are sensitive to forebrain manipulations (Helmstetter & Bellgowan, 1993; King et al, 1999; LeDoux, Iwata, Cicchetti, & Reis, 1988; Meagher, Crown, Ferguson, & Grau, 2001) and are thought to provide a better index of the affective component of pain (Borszcz, 1995b; Carroll & Lim, 1960; Hoffmeister, 1968; King et al, 1996; Sieve, King, Crown, Meagher, & Grau, 1998; Sieve, King, Grau, & Meagher, 2001).…”

Section: Resultsmentioning

confidence: 99%

Shock-induced hyperalgesia: IV. Generality.

Meagher¹,

Ferguson²,

Crown³

et al. 2001

Journal of Experimental Psychology: Animal Behavior Processes

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Brief-moderate shock (3, 0.75 s, 1.0 mA) has opposite effects on different measures of pain, inducing antinociception on the tail-flick test while lowering vocalization thresholds to shock and heat (hyperalgesia) and enhancing fear conditioned by a gridshock unconditioned stimulus (US). This study examined the generality of shock-induced hyperalgesia under a range of conditions and explored parallels to sensitized startle. Reduced vocalization thresholds to shock and antinociception emerged at a similar shock intensity. Severe shocks (3, 25 s, 1.0 mA or 3, 2 s, 3.0 mA) lowered vocalization threshold to shock but increased vocalization and motor thresholds to heat and undermined fear conditioned by a gridshock or a startling tone US. All shock schedules facilitated startle, but only brief-moderate shock inflated fear conditioning. The findings suggest that brief-moderate shock enhances the affective impact of aversive stimuli, whereas severe shocks attenuate pain.

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