Pain and thyroid hormones

Aloisi, Anna Maria; Vodo, Stella; Buonocore, Michelangelo

doi:10.1007/s10072-013-1440-7

Cited by 14 publications

(11 citation statements)

References 59 publications

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“…Indicatively, it has been observed that thyroid autoimmunity is facilitated by single nucleotide polymorphisms in genes regulating the immune system, such as human leukocyte antigen genes, cytokines genes, and thyroid specific genes, while polymorphisms in some of these genes have also been implicated in migraine pathogenesis . Furthermore, recent studies have shown that thyroid hormones are involved in pain mechanisms with TSH receptors being expressed in the cortical neurons and cerebral vasculature . There are several mechanisms that may explain how migraine could be a risk factor for hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Migraine and Tension‐Type Headache With Hypothyroidism: A Literature Review

et al. 2019

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Background Migraine, tension‐type headache, and hypothyroidism constitute very common medical conditions. Headache is one of the most common symptoms of hypothyroidism, occurring in approximately one‐third of the patients. To date, data about the relationship between migraine and tension‐type headache and thyroid dysfunction, and in particular hypothyroidism have been contradictory, while the underlying pathophysiological basis explaining this association is still unclear. Objective In this review, we investigated the association between primary headaches and hypothyroidism, with the aim of shedding light on its pathophysiological basis. Methods We conducted a systematic search in the MEDLINE database using both subject headings and keywords for headache, migraine, tension‐type headache, thyroid hormones, and hypothyroidism, and we also examined manually the reference lists of all articles that met the inclusion criteria. Included studies were related to headache and thyroid disease comorbidity, with emphasis on hypothyroidism (ideally demonstrated by hormonal measurements), and with the term headache including migraine, tension‐type headache, and headache attributed to hypothyroidism (HAH) based on the International Classification of Headache Disorders IIIb. Quality of studies was assessed by the Newcastle‐Ottawa scale. Results Of a total of 640 identified articles, 9 studies were included. Overall, there was vast heterogeneity across the included studies concerning population, study design and outcomes. Two studies investigated the HAH, with emphasis on the clinical characteristics of headache (time of onset, localization, quality, intensity, and response to hormonal replacement treatment). Five studies investigated comorbidity between migraine and thyroid disorders, especially hypothyroidism, and in the majority of them a positive association was demonstrated. One study found that headache, and particularly migraine, may increase the risk of developing hypothyroidism. Finally, only 1 study on chronic tension‐type headache found coexistence of migraine and hypoactivity of the hypothalamus‐pituitary‐thyroid axis. The strengths and limitations of these studies are analyzed and possible pathophysiological mechanisms are suggested. Conclusions The existing data are considered inadequate to answer with certainty the relationship between headaches and thyroid disorders. According to our analysis, it seems that suggestions for a possible bidirectional association between headaches and especially migraine and hypothyroidism could exist. It hence lays the foundation for further research into the aforementioned association and its pathogenesis via large prospective multicenter studies.

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Section: Discussionmentioning

confidence: 99%

Relationship of Migraine and Tension‐Type Headache With Hypothyroidism: A Literature Review

et al. 2019

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“…Recent studies explained the comorbidity by involvement of thyroid hormone in pain mechanisms with thyrotropin stimulating hormone receptors being expressed in the cortical neurons and cerebral vasculature [7].…”

Section: Introductionmentioning

confidence: 99%

Migraine and tension headache comorbidity with hypothyroidism in Egypt

Elmaaty

Flifel

Belal

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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Background: Migraine, tension type headache (TTH), and hypothyroidism are clinical problems that affect patient daily activities and quality of life. Objectives: The purpose of this study was to investigate the potential association between hypothyroidism in patients with migraine and TTH. Patients and methods: Two hundred and twelve patients with migraine and TTH and one hundred control subjects underwent clinical evaluation, assessment of thyroid hormones, and thyroid ultrasound. Results: Subclinical and overt hypothyroidism were significantly higher in patients with migraine and TTH (P = 0.001) than control subjects. Patients with migraine and TTH showed significantly more abnormal thyroid gland morphology than healthy control (P = 0.027). Hypothyroidism is significantly expressed in chronic TTH more than TTH with infrequent or frequent TTH (P = 0.009). Conclusions: Patients having migraine and TTH more prone to develop hypothyroidism when compared with control group. Also patients with chronic TTH are susceptible to develop hypothyroidism (either subclinical or overt) when compared with patients having frequent or infrequent TTH.

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“…Many reports can be found in the literature concerning thyroid hormones and their functions; however, studies of their connection with pain are scarce. The thyroid gland has a prominent role in tissue metabolism and development; in addition, the hypothalamic-pituitary-thyroid axis is central to the modulation and neurotransmission processes in the central nervous system [ 17 ] .…”

Section: Discussionmentioning

confidence: 99%

“…Aloisi et al [ 17 ] , in a pilot study with a group of 200 women with chronic pain - whose medical history was investigated - found that 19% of them had some degree of thyroid dysfunction. That rate is similar to the overall value of 16.3% found in our analysis.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with the Development of Chronic Post-Sternotomy Pain: A Case-Control Study

Costa¹,

Trentini²,

Schafranski³

et al. 2015

Revista Brasileira De Cirurgia Cardiovascular

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OBJECTIVE The aim of the present study was to investigate the factors associated with chronic post-sternotomy pain in heart surgery patients.METHODS Between January 2013 and February 2014, we evaluated 453 patients with >6 months post-sternotomy for cardiac surgery at a surgical outpatient clinic. The patients were allocated into a group with chronic post-sternotomy pain (n=178) and a control group without pain (n=275). The groups were compared for potential predictors of chronic post-sternotomy pain. We used Cox proportional hazards regression to determine which independent variables were associated with the development of chronic post-sternotomy pain.RESULTS In total, 39.29% of the patients had chronic poststernotomy pain. The following factors were significantly associated with chronic post-sternotomy pain: (a) use of the internal thoracic artery in coronary bypass grafting (P=0.009; HR=1.39; 95% CI, 1.08 to 1.80); (b) a history of antidepressant use (P=0.0001; HR=2.40; 95% CI, 1.74 to 3.32); (c) hypothyroidism (P=0.01; HR=1.27; 95% CI, 1.03 to 1.56); (d) surgical wound complication (P=0.01; HR=1.69; 95% CI, 1.08 to 2.63), and (e) patients on disability benefits or scheduled for a consultative medical examination for retirement (P=0.0002; HR=2.05; 95% CI, 1.40 to 3.02).CONCLUSION The factors associated with chronic poststernotomy pain were: use of the internal thoracic artery; use of antidepressants; hypothyroidism; surgical wound complication, and patients on disability benefits or scheduled for a consultative examination.

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Pain and thyroid hormones

Cited by 14 publications

References 59 publications

Relationship of Migraine and Tension‐Type Headache With Hypothyroidism: A Literature Review

Relationship of Migraine and Tension‐Type Headache With Hypothyroidism: A Literature Review

Migraine and tension headache comorbidity with hypothyroidism in Egypt

Factors Associated with the Development of Chronic Post-Sternotomy Pain: A Case-Control Study

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