Pain as a symptom of depression: Prevalence and clinical correlates in patients attending psychiatric clinics

Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression

“…Depression and chronic pain are widely recognised clinical co-morbidities, with up to 50% of chronic pain patients exhibiting depression (Radat et al, 2013), while almost 60% of depressed patients experience painful physical symptoms (Aguera-Ortiz et al, 2011). Recent data from animal studies support this clinical relationship and indicate that inflammatory and neuropathic pain-related responding is enhanced in various animal models of depression including olfactory bulbectomy (OB) (Burke et al, 2013a, Burke et al, 2010, early life stress (Uhelski andFuchs, 2010, Burke et al, 2013b) and the Wistar-Kyoto rat (Burke et al, 2010, Zeng et al, 2008, Rea et al, 2014.…”

Neuropathic Pain and Depression: A Prospective Study to find out Any Association

“…5,6 The most common association of pain is with depression which has been extensively studied. [7][8][9][10][11][12][13][14][15] Studies have also being conducted utilizing the neuroimaging in order to find out the complexity of pain and depression network. [16][17][18][19][20] The prevalence of depression in patients with chronic pain is reported to be between 18 and 85% depending on the conducted survey.…”

“…21 The prevalence of chronic pain in patients treated for depression is reported to be between 51.8 and 59.1%. [8][9][10] A longitudinal cohort study with a 1 year follow-up of the patient's baseline pain, severity and duration has reported a significant association with depression. 15 Fishbain et al 22 have reported a significant correlation between degree of depression and severity of pain.…”

Coexistence of Chronic Pain and Depression: A Short Review with a Focus on the Antidepressant Effect of Tramadol and Buprenorphine

“…30-54% of depressed patients treated in specialized psychiatric centres [13,14]. It has been shown that people with depressive disorders have a lowering of the pain threshold and a stronger emotional and cognitive perception of pain, which eventually becomes a chronic pain [15].…”

“…In primary care, pain is declared by nearly 70% of depressed patients, compared to 38.6% of patients without depression [43]. In the meta-analysis conducted by Agürer-Ortiz et al [15], it was found that in 3566 adult patients with depressive disorders, pain occurred in 59% of subjects, more frequently in women than in men and more often in patients > 50 years of age. The pain most often concerned the back area and the sacral area.…”