Pain aspects in oocyte aspiration for IVF

Gejervall, Ann-Louise; Stener-Victorin, Elisabet; Cerne, A.; Borg, Kia; Bergh, Christina

doi:10.1016/s1472-6483(10)60786-9

Cited by 16 publications

(11 citation statements)

References 26 publications

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“…This appears to suggest that psychosocial factors are more important predictors of the OR-related pain experience than medical factors. Aspiration of oocytes is a crucial and anxiety-provoking part of IVF/ICSI fertility treatment [3,23]. As a majority of the women may require repeated attempts in order to achieve a pregnancy, experiencing high levels of pain during the OR procedure may cause not only procedural problems such as prolongation, side effects, premature termination of the procedure, but also increased worry and distress.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 7% of the women in our sample found the oocyte retrieval procedure to be very or extremely painful; a result similar to an earlier finding by Højgaard et al (2001) [13], who found that 6% reported unacceptable pain levels. Although 7% appears to be a relatively small number, other studies have shown that more than half of the women report moderate to high pain levels [3,24], and our chosen cut-off (0-4 vs. 5-6) between high and low pain could be viewed as conservative. Nevertheless, even a small group of 7% with intolerable pain stresses the importance of identifying individual characteristics that may indicate need for special interventions to alleviate pain during the procedure.…”

Section: Discussionmentioning

confidence: 99%

“…It is widely accepted that the pain experience is related not only to biological factors, and several psychosocial factors have been found to influence pain intensity and pain tolerance [2] . Anxiety, for example, has been described to be associated with lower pain threshold [3], and the feeling of being in control associated with more efficient pain coping. Many women in fertility treatment are anxious, not only in relation to the OR procedure itself, but they also display various levels of anxiety related to the involuntary childlessness in general [5].…”

Section: Introductionmentioning

confidence: 99%

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Predictors of pain during oocyte retrieval

Frederiksen

Mehlsen

Matthiesen

et al. 2016

Journal of Psychosomatic Obstetrics & Gynecology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predictors of pain during oocyte retrieval

Frederiksen

Mehlsen

Matthiesen

et al. 2016

Journal of Psychosomatic Obstetrics & Gynecology

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“…[ 3 ] Other studies also confirmed that more than half of the women suffer pain during oocyte retrieval. [ 4 , 5 ] Moreover, pelvic organs and blood vessels can be damaged by aspiration needles, and life-threatening complications related to infection or anesthesia may occur. Types of analgesia that have been used clinically for oocyte extraction include conscious sedation, [ 6 , 7 ] general anesthesia, [ 8 ] local injection as a paracervical block (PCB) [ 9 – 14 ] and patient-controlled analgesia.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture for pain relief of women undergoing transvaginal oocyte retrieval

Guo

Li²,

Wei³

et al. 2020

Medicine

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Background: Pain during oocyte retrieval, which can make the in-vitro fertilization process an unpleasant experience, is becoming a common problem. Although there are many analgesic methods available in the clinical setting, they are not therapeutically equivalent, and some are associated with varying adverse reactions. In recent years, acupuncture analgesia has been used in the perioperative period of oocyte retrieval because of its perceived efficacy and safety. The purpose of this systematic review and meta-analysis is to provide evidence that acupuncture is effective in the treatment of vaginal oocyte retrieval pain. Methods: Electronic searches of the following six databases will be conducted by two qualified reviewers: MEDLINE, EMBASE, China National Knowledge Infrastructure, Chinese Biomedical Medicine database, VIP database and Wanfang database. Three clinical trial registries will also be searched: World Health Organization International Clinical Trial Registry Platform, Chinese Clinical Trial Registry, Cochrane Central Register of Controlled Trials and ClinicalTrials.Gov. All searches will cover the period from inception of the database/registry to March 2020 and will be limited to publications in English and Chinese. Data identification, data selection, data extraction, and bias risk assessment will be conducted independently by3ν two or more qualified reviewers, including those who selected the studies. Visual analogue scale scores will be calculated as the primary outcome. Secondary outcomes will include results of other subjective pain rating scales, including Likert scales or other defined numerical or non-numerical scales, self-assessed by patients before, during, and after oocyte retrieval. We will use STATA software (Version 16) to perform meta-analyses, and the Grading of Recommendations, Assessment, Development and Evaluations framework to grade the quality of evidence. If quantitative analysis is not available, a systematic narrative synthesis will be provided. PROSPERO registration number: CRD42020170095.

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“…Oocyte retrieval is only one of many steps and painful procedures that women will experience before becoming a parent. Women undergoing ART report escalating pelvic discomfort in the later stages of ovulation induction and most women use potent analgesics following oocyte retrieval procedures [2,3]. Because post-procedural pain has not been extensively studied and management is challenging due to concerns that anti-inflammatory drugs may interfere with the fertility process, women are at risk for being either under or over-treated with prescribed opioids that may not necessarily be effective or even needed.…”

Section: Introductionmentioning

confidence: 99%

Hormonal and Clinical Predictors for Post–egg Retrieval Pain in Women Undergoing Assisted Reproductive Technology Procedures

Vuilleumier

Dinges

Ciliberto

et al. 2016

The Clinical Journal of Pain

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ObjectivesThe intensity of post-egg retrieval pain is underestimated, with few studies examining postprocedural pain and predictors to identify women at risk for severe pain. We evaluated the influence of pre-procedural hormonal levels, ovarian factors, as well as mechanical temporal summation (mTS) as predictors for post-egg retrieval pain in women undergoing in vitro fertilization (IVF). MethodsEighteen women scheduled for ultrasound-guided egg retrieval under standardized anesthesia and post-procedural analgesia were enrolled. Pre-procedural mTS, questionnaires, clinical data related to anesthesia and the procedure itself, post-procedural pain scores and pain medication for breakthrough pain were recorded. Statistical analysis included Pearson product moment correlations, Mann-Whitney U tests and multiple linear regressions. ResultsAverage peak post-egg retrieval pain during the first 24 hours was 5.0 ± 1.6 on an NRS scale (0=no pain, 10=worst pain imaginable). Peak post-egg retrieval pain was correlated with basal antimullerian hormone (AMH) (r=0.549, p=0.018), pre-procedural peak estradiol (r=0.582, p=0.011), total number of follicles (r=0.517, p=0.028) and number of retrieved eggs (r=0.510, p=0.031). Ovarian hyperstimulation syndrome (OHSS) (n=4) was associated with higher basal AMH (p=0.004), higher peak pain scores (p=0.049), but not with peak estradiol (p=0.13). The mTS did not correlate with peak post-procedural pain (r=0.266, p=0.286), or peak estradiol level (r=0.090, p=0.899).Copyright © 2015 Wolters Kluwer Health, Inc. Unauthorized reproduction of the article is prohibited. DiscussionPeak post-egg retrieval pain intensity was higher than anticipated. Our results suggest that post-egg retrieval pain can be predicted by baseline AMH, high peak estradiol, and OHSS.Further studies to evaluate intra-and post-procedural pain in this population are needed, as well as clinical trials to assess post-procedural analgesia in women presenting with high hormonal levels.

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Pain aspects in oocyte aspiration for IVF

Cited by 16 publications

References 26 publications

Predictors of pain during oocyte retrieval

Predictors of pain during oocyte retrieval

Acupuncture for pain relief of women undergoing transvaginal oocyte retrieval

Hormonal and Clinical Predictors for Post–egg Retrieval Pain in Women Undergoing Assisted Reproductive Technology Procedures

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