Pain catastrophizing and neural responses to pain among persons with fibromyalgia

Gracely, Richard H.; Geisser, Michael E.; Giesecke, Thorsten; Grant, Masilo; Petzke, Frank; Williams, David A.; Clauw, Daniel J.

doi:10.1093/brain/awh098

Cited by 779 publications

(578 citation statements)

References 42 publications

Supporting

Mentioning

518

Contrasting

Unclassified

Order By: Relevance

“…The RC index of the FIQ physical impairment scale indicated responder rates of 58.1%, 38.1%, and 2.5% in the OBT, CBT, and AP groups, respectively ( 2 [2] ϭ 14.95, P Ͻ 0.005). The percentage of CBT and OBT responders was significantly higher than that of the AP responders (CBT versus AP: 2 [1] ϭ 7.23, P Ͻ 0.05; OBT versus AP: 2 [1] ϭ 14.02, P Ͻ 0.001). CBT and OBT responders were not significantly different (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…The combination of pain ( 2 [ Canonical discriminant analyses found that pain behavior discriminated the CBT group from the OBT and AP groups (Wilks' [2] ϭ 0.488, P Ͻ 0.001; F[2] ϭ 11.561, P Ͻ 0.001). CBT patients responding with clinically significant reduction of physical impairment showed lower pain behaviors prior to the treatment in contrast to OBT responders who showed a greater number of pain behaviors and AP patients who displayed extremely high pain behaviors.…”

Section: Resultsmentioning

confidence: 99%

“…Patients diagnosed with FMS also report poor coping ability (2,3) and display overt expressions of pain (i.e., pain behaviors [4,5]), suggesting that psychological processes may contribute to the maintenance of symptoms and disability (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…Even though the results that have been reported indicate statistically significant improvements on some outcome criteria, a significant percentage of patients do not demonstrate clinically significant benefits (17). Most of the published clinical outcome studies have treated patients as homogeneous groups based on the diagnosis of FMS despite the patient heterogeneity observed in both physiologic variables (18 -20) and psychosocial characteristics (2,21,22). The results observed with CBT and OBT raise an important question regarding which patients are most likely to benefit from these treatments, which have different emphases.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Responder criteria for operant and cognitive–behavioral treatment of fibromyalgia syndrome

Thieme¹,

Turk²,

Flor³

2007

Arthritis & Rheumatism

105

View full text Add to dashboard Cite

Objective. To predict the effects of cognitive-behavioral therapy (CBT) and operant-behavioral therapy (OBT) in fibromyalgia syndrome (FMS).Methods. A total of 125 patients who fulfilled the American College of Rheumatology FMS criteria were randomly assigned to CBT (n ‫؍‬ 42), OBT (n ‫؍‬ 43), or attention placebo (AP; n ‫؍‬ 40). The pretreatment to 12-month followup reliability change index was used to determine clinically meaningful changes in pain intensity and physical impairment. Multinominal logistic regression analyses were used to determine the predictors of improvement in pain intensity and physical impairment for the entire sample. Analyses of variance were computed to compare the characteristics of responders and nonresponders in each of the 3 interventions. Results. At the 12-month followup, 53.5%, 45.2%, and 5% of patients in the OBT, CBT, and AP groups, respectively, reported clinically meaningful improvements in pain intensity. Similarly, 58.1%, 38.1%, and 7.5% of patients treated with OBT, CBT, and AP, respectively, reported clinically significant improvements in physical impairment. Prior to treatment, the OBT physical impairment responders displayed significantly more pain behaviors, physical impairment, physician visits, solicitous spouse behaviors, and level of catastrophizing compared with nonresponders. The CBT physical impairment responders, compared with nonresponders, reported higher levels of affective distress, lower coping, less solicitous spouse behavior, and lower pain behaviors. Conclusion. The results of this study suggest that pretreatment patient characteristics are important predictors of treatment response and may serve as a basis for matching treatments to patient characteristics. Prospective outcome studies are needed to confirm whether the tailoring of treatment actually leads to better outcomes for patients with FMS.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Responder criteria for operant and cognitive–behavioral treatment of fibromyalgia syndrome

Thieme¹,

Turk²,

Flor³

2007

Arthritis & Rheumatism

105

View full text Add to dashboard Cite

show abstract

“…Pain catastrophizing is suggested to increase pain sensitivity through enhanced attention to painful stimuli as well as heightened emotional responses to pain. Indeed, catastrophizing has been associated with increased activity in brain areas related to anticipation of pain, attention to pain, and emotional aspects of pain and motor control 21,38 . Those who catastrophize about pain preferentially process pain-related information and interpret even ambiguous sensations as painful 41 .…”

Section: Discussionmentioning

confidence: 99%

In Vivo Praying and Catastrophizing Mediate the Race Differences in Experimental Pain Sensitivity

Meints

Hirsh

2015

The Journal of Pain

View full text Add to dashboard Cite

Black individuals have a lower tolerance for experimental pain than White individuals. Black and White individuals also differ in their use of pain coping strategies, which may explain the race differences in pain sensitivity. We examined the extent to which situation-specific pain coping mediated Black-White differences in pain sensitivity. We hypothesized that: (1) Black participants would demonstrate lower pain tolerance than White participants, (2) Black participants would use different pain coping strategies than White participants, and (3) the differential use of these strategies would mediate the relationship between race and pain tolerance. Healthy college undergraduates (N=190) participated in a cold pressor task and then completed the CSQ-R to assess their situation-specific pain coping. Compared to White participants, Black participants demonstrated lower pain tolerance, engaged in more situationspecific catastrophizing and praying, and ignored pain less frequently. Catastrophizing and praying were inversely related to pain tolerance and were significant mediators of the relationship between race and pain tolerance. The indirect effect of praying was stronger than that of catastrophizing. Race differences in pain sensitivity may be due, in part, to differences in the use of catastrophizing and praying as coping strategies. These results may help guide treatments addressing maladaptive pain coping. Perspective:This study suggests that race differences in pain sensitivity may be due, in part, to the differential use of catastrophizing and praying strategies. Psychosocial treatments for pain should encourage patients to take an active role in their pain management.

show abstract

Association of Major Depressive Disorder With Altered Functional Brain Response During Anticipation and Processing of Heat Pain

Strigo¹,

Simmons²,

Matthews³

et al. 2008

Arch Gen Psychiatry

238

188

View full text Add to dashboard Cite

Context Chronic pain and depression are highly comorbid conditions, yet little is known about the neurobiological basis of pain processing in major depressive disorder (MDD). Objective To examine the neural substrates underlying anticipation and processing of heat pain in a group of unmedicated young adults with current MDD. Design Functional magnetic resonance neuroimaging (fMRI) data were collected during an event-related factorial experimental pain paradigm. Painful and non-painful heat stimuli were applied to the left volar forearm while different color shapes explicitly signaled the intensity of the upcoming stimulus. Setting University brain imaging center. Patients 15 (12 F) young adults with current MDD and 15 (10F) healthy subjects with no history of MDD were recruited and matched for age and level of education. The Structured Clinical Interview for DSM-IV was administered to all participants by a board-certified psychiatrist. Main Outcome measure Between-group differences in blood oxygen level-dependent fMRI signal change to anticipation and processing of painful versus non-painful temperature stimuli. Results MDD compared to healthy controls showed: (1) increased activation in right anterior insular region, dorsal anterior cingulate and right amygdala during anticipation of painful relative to non-painful stimuli, (2) increased activation in right amygdala and decreased activation in periaqueductal gray, rostral anterior cingulate and prefrontal cortices during painful stimulation relative to non-painful stimulation, and (3) in MDD subjects greater activation in the right amygdala during anticipation of pain was associated with greater levels of perceived helplessness. Conclusion These findings suggest that increased emotional reactivity during the anticipation of heat pain may lead to an impaired ability to modulate pain experience in MDD. Future studies should examine the degree to which altered functional brain response during anticipatory processing affects ability to modulate negative affective states in MDD, which is a core characteristic of this disorder.

show abstract

Pain catastrophizing and neural responses to pain among persons with fibromyalgia

Cited by 779 publications

References 42 publications

Responder criteria for operant and cognitive–behavioral treatment of fibromyalgia syndrome

Responder criteria for operant and cognitive–behavioral treatment of fibromyalgia syndrome

In Vivo Praying and Catastrophizing Mediate the Race Differences in Experimental Pain Sensitivity

Association of Major Depressive Disorder With Altered Functional Brain Response During Anticipation and Processing of Heat Pain

Contact Info

Product

Resources

About