Pain catastrophizing predicts alcohol craving in heavy drinkers independent of pain intensity

Nieto, Steven J.; Green, ReJoyce; Grodin, Erica N.; Cahill, Catherine M.; Ray, Lara A.

doi:10.1016/j.drugalcdep.2020.108368

Cited by 17 publications

(15 citation statements)

References 65 publications

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“…That study, which tested associations between pain and alcohol consumption and motives among 128 patients seeking AUD treatment, also examined pain catastrophizing as a predictor variable of all outcomes. 91 Results indicated that pain catastrophizing was associated with greater alcohol craving, AUD symptoms, and normalizing drinking motives, regardless of pain intensity.…”

Section: Resultsmentioning

confidence: 89%

“…Among a sample of patients seeking treatment for AUD ( N = 128), high-intensity pain ratings (vs. no or low-intensity pain) were associated with a greater number of self-reported drinks per day and higher alcohol craving, and participants with high-intensity pain were more likely to report normalizing motives for drinking (i.e., “to feel normal”). 91 Finally, researchers recently developed and validated the Expectancies for Alcohol Analgesia measure, which assesses perceived likelihood of pain relief from drinking. In a sample of 273 people who reported chronic pain and current alcohol use, expectancies for analgesia were associated with reporting greater frequency and quantity of alcohol use and identifying coping as a motive for drinking.…”

Section: Resultsmentioning

confidence: 99%

“… 114 The review further observed consistent evidence that people with chronic pain are motivated to use alcohol and prescription opioids in response to negative affect 94 , 95 and maladaptive pain-related cognitions (e.g., catastrophic thinking). 91 , 100 Finally, this review found initial evidence suggesting that difficulty managing aversive internal states is associated with risk for opioid misuse, 110 and that people with chronic pain hold unique motives and perceptions about how their pain and drinking are interrelated. 90 …”

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Cognitive-Affective Transdiagnostic Factors Associated With Vulnerability to Alcohol and Prescription Opioid Use in the Context of Pain

Zale

Powers

Ditre

2021

ARCR

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The use of alcohol and prescription opioids is common among people in pain and poses significant public health burdens. This review identifies factors associated with motivation to use alcohol and prescription opioids in the context of pain. Pain-relevant, cognitive-affective, transdiagnostic vulnerability factors—expectancies/motives, pain catastrophizing, pain-related anxiety, distress intolerance, anxiety sensitivity, and perceived interrelations—were selected from theoretical conceptualizations of pain and substance use. Searches conducted in PubMed, PsycINFO, and Embase returned 25 studies that examined associations between identified variables of interest and the use of alcohol and prescription opioids in the context of pain. Consistent with a larger literature on pain and substance use, the studies included in this review demonstrated that people with chronic pain are motivated to use alcohol and opioids in response to negative affect and hold expectancies/motives for coping with pain. Vulnerabilities that engender difficulty managing aversive internal states (distress intolerance and anxiety sensitivity) and maladaptive responses to pain (pain-related anxiety and pain catastrophizing) also were implicated in motivation for alcohol and opioid use. Although one study found that pain-related anxiety was associated with co-use of alcohol and opioids, no studies examined simultaneous use. Future research directions that can explicate causal associations, identify patterns of alcohol and opioid co-use, clarify the role of pain in cessation processes, and inform treatment development are discussed.

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Cognitive-Affective Transdiagnostic Factors Associated With Vulnerability to Alcohol and Prescription Opioid Use in the Context of Pain

Zale

Powers

Ditre

2021

ARCR

View full text Add to dashboard Cite

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“…Nevertheless, psychosocial factors are also highly present in patients with alcohol abuse and can be attributed to abnormalities in the reward system of the brain [ 114 ]. Additionally, a recently published study demonstrated that chronic pain patients with high levels of pain catastrophising are more likely to be heavy drinkers [ 115 ]. General advice on alcohol consumption after cancer is currently not possible due to the high variability of results in different CSs.…”

Section: State-of-the-artmentioning

confidence: 99%

Lifestyle and Pain following Cancer: State-of-the-Art and Future Directions

Lahousse

Roose

Leysen

et al. 2021

JCM

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This review discusses chronic pain, multiple modifiable lifestyle factors, such as stress, insomnia, diet, obesity, smoking, alcohol consumption and physical activity, and the relationship between these lifestyle factors and pain after cancer. Chronic pain is known to be a common consequence of cancer treatments, which considerably impacts cancer survivors’ quality of life when it remains untreated. Improvements in lifestyle behaviour are known to reduce mortality, comorbid conditions (i.e., cardiovascular diseases, other cancer, and recurrence) and cancer-related side-effects (i.e., fatigue and psychological issues). An inadequate stress response plays an important role in dysregulating the body’s autonomic, endocrine, and immune responses, creating a problematic back loop with pain. Next, given the high vulnerability of cancer survivors to insomnia, addressing and treating those sleep problems should be another target in pain management due to its capacity to increase hyperalgesia. Furthermore, adherence to a healthy diet holds great anti-inflammatory potential for relieving pain after cancer. Additionally, a healthy diet might go hand in hand with weight reduction in the case of obesity. Consuming alcohol and smoking have an acute analgesic effect in the short-term, with evidence lacking in the long-term. However, this acute effect is outweighed by other harms on cancer survivors’ general health. Last, informing patients about the benefits of an active lifestyle and reducing a sedentary lifestyle after cancer treatment must be emphasised when considering the proven benefits of physical activity in this population. A multimodal approach addressing all relevant lifestyle factors together seems appropriate for managing comorbid conditions, side-effects, and chronic pain after cancer. Further research is needed to evaluate whether modifiable lifestyle factors have a beneficial influence on chronic pain among cancer survivors.

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“…Hyper-negative emotional states and hyperalgesia are both consequences of repeated alcohol use [ 46 ] and may contribute to an increase in alcohol use as a compensatory mechanism [ 47 ]. Among heavy drinkers, the negative emotional components of pain (i.e., pain catastrophizing) can enhance alcohol craving more than physical pain [ 48 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine

Cameron¹,

Nieto²,

Bosler³

et al. 2021

Adv. Drug Alcohol Res.

Self Cite

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Death by suicide is a global epidemic with over 800 K suicidal deaths worlwide in 2012. Suicide is the 10th leading cause of death among Americans and more than 44 K people died by suicide in 2019 in the United States. Patients with chronic pain, including, but not limited to, those with substance use disorders, are particularly vulnerable. Chronic pain patients have twice the risk of death by suicide compared to those without pain, and 50% of chronic pain patients report that they have considered suicide at some point due to their pain. The kappa opioid system is implicated in negative mood states including dysphoria, depression, and anxiety, and recent evidence shows that chronic pain increases the function of this system in limbic brain regions important for affect and motivation. Additionally, dynorphin, the endogenous ligand that activates the kappa opioid receptor is increased in the caudate putamen of human suicide victims. A potential treatment for reducing suicidal ideation and suicidal attempts is buprenorphine. Buprenorphine, a partial mu opioid agonist with kappa opioid antagonist properties, reduced suicidal ideation in chronic pain patients with and without an opioid use disorder. This review will highlight the clinical and preclinical evidence to support the use of buprenorphine in mitigating pain-induced negative affective states and suicidal thoughts, where these effects are at least partially mediated via its kappa antagonist properties.

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Pain catastrophizing predicts alcohol craving in heavy drinkers independent of pain intensity

Cited by 17 publications

References 65 publications

Cognitive-Affective Transdiagnostic Factors Associated With Vulnerability to Alcohol and Prescription Opioid Use in the Context of Pain

Cognitive-Affective Transdiagnostic Factors Associated With Vulnerability to Alcohol and Prescription Opioid Use in the Context of Pain

Lifestyle and Pain following Cancer: State-of-the-Art and Future Directions

Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine

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