Pain, Coping, and Sleep in Children and Adolescents With Sickle Cell Disease

Graves, RN Joyce Kelly; Jacob, RN Eufemia

doi:10.1111/jcap.12077

Cited by 56 publications

(84 citation statements)

References 55 publications

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“…Two-thirds of the participants reported experiencing pain in the preceding month, 91.2% had some degree of sleep disturbance, while 18.2% required sleeping medications. In this study, there was a non-statistically significant trend towards higher PSQI score with increasing pain severity, but not with pain frequency [193]. Two other studies showed that SCD was associated with increased frequency and severity of sleep disturbances in middle-school children and adolescents that resembled the patterns reported for other chronic pain syndromes (e.g., juvenile idiopathic arthritic and headache), with one notable exception e SCD was associated with a much higher prevalence of sleep-disordered breathing [194,195].…”

Section: Erectile Dysfunctioncontrasting

confidence: 62%

Hemoglobinopathies and sleep – The road less traveled

Gileles‐Hillel

Kheirandish‐Gozal

Gozal

2015

Sleep Medicine Reviews

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Section: Erectile Dysfunctioncontrasting

confidence: 62%

Hemoglobinopathies and sleep – The road less traveled

Gileles‐Hillel

Kheirandish‐Gozal

Gozal

2015

Sleep Medicine Reviews

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“…50 In a cohort of children and adolescent SCD patients, depression was also associated with worse HRQoL scores in all domains. 51 Depression was found to be associated with neurocognitive deficits in other patient populations. 52,53 However, assessment of neurocognitive functions showed no difference between those with depression and those without depression in this study, perhaps because this population in general has altered neurocognitive functioning due to SCD-associated neurological complications.…”

Section: Discussionmentioning

confidence: 99%

Depression, quality of life, and medical resource utilization in sickle cell disease

et al. 2017

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Key Points• Depression was found in 35.2% of adult SCD patients and was strongly associated with worse physical and mental quality-of-life outcomes.• Total health care costs for adult SCD patients with depression were more than double those of SCD patients without depression.Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with SCD and its association with HRQoL and medical resource utilization. Depression was measured by the Beck Depression Inventory and clinical history in adult SCD outpatients at a comprehensive SCD center. HRQoL was assessed using the SF36 form, and data were collected on medical resource utilization and corresponding cost. Neurocognitive functions were assessed using the CNS Vital Signs tool.Pain diaries were used to record daily pain. Out of 142 enrolled patients, 42 (35.2%) had depression. Depression was associated with worse physical and mental HRQoL scores (P , .0001 and P , .0001, respectively). Mean total inpatient costs ($25 000 vs $7487, P 5 .02) and total health care costs ($30 665 vs $13 016, P 5 .01) were significantly higher in patients with depression during the 12 months preceding diagnosis. Similarly, during the 6 months following diagnosis, mean total health care costs were significantly higher in depressed patients than in nondepressed patients ($13 766 vs $8670, P 5 .04). Depression is prevalent in adult patients with SCD and is associated with worse HRQoL and higher total health care costs. Efforts should focus on prevention, early diagnosis, and therapy for depression in SCD.

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“…On average, individuals with SCD report pain on 22% of days [41] and those with a diagnosis of avascular necrosis (AVN) experience more subjective sleep difficulties than those with SCD but no radiological evidence of AVN [80]. Studies of sleep disturbance in pediatric SCD have included both subjective [41,[80][81][82][83][84][85][86][87][88][89] and objective [85,[90][91][92][93] sleep measures; however, studies frequently lack a healthy control group and child self-report.…”

Section: Sickle Cell Diseasementioning

confidence: 99%