Pain experience in Fibromyalgia Syndrome: The role of alexithymia and psychological distress

Tella, Marialaura Di; Ghiggia, Ada; Tesio, Valentina; Romeo, Annunziata; Colonna, Fabrizio; Fusaro, Enrico; Torta, Riccardo; Castelli, Lorys

doi:10.1016/j.jad.2016.08.080

Cited by 82 publications

(63 citation statements)

References 44 publications

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“…This affect regulation may be related to other GABAergic (sedative) and serotonergic (stimulant) central pathways differing from above mentioned resilience and adaptation mechanisms of nociception regulation. From an evolutionary viewpoint, the putative “pain aggravation” mechanism is a part of a general affective alarm mechanism for enhancing or substituting insufficient sensory (visceral, proprioceptive, and nociceptive) harm‐related signaling to consciousness for behavior change to coping with the problem in those with deficits in sensory processing like some alexithymia components …”

Section: Discussionmentioning

confidence: 99%

“…From an evolutionary viewpoint, the putative "pain aggravation" mechanism is a part of a general affective alarm mechanism for enhancing or substituting insufficient sensory (visceral, proprioceptive, and nociceptive) harm-related signaling to consciousness for behavior change to coping with the problem in those with deficits in sensory processing like some alexithymia components. [90][91][92][93] Lifestyle (cigarette smoking, alcohol, caffeine, and exercise) factors were additionally reviewed for their probable mediation effects through explored CV asymmetry variables on protection of health or exacerbation of IBS severity. All found effects were independent of the IBS chronicity.…”

Section: Discussionmentioning

confidence: 99%

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Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome

Davydov

Naliboff

Shahabi

et al. 2017

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome

Davydov

Naliboff

Shahabi

et al. 2017

Neurogastroenterology Motil

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“…Nevertheless, care must be taken because this disorder is often misdiagnosed. One study has evaluated the relation between pain and distress, analyzing possible risk and exacerbating factors such as alexithymia . Dysthymic disorder was diagnosed in 15% of all chronic pain patients and in 17% of fibromyalgia patients.…”

Section: Discussionmentioning

confidence: 99%

Frequency of mental disorders among chronic pain patients with or without fibromyalgia in Japan

Miki

Nakae

Shi³

et al. 2018

Neuropsychopharm Rep

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Aim To explore the characteristics of psychiatric morbidity in chronic pain patients who present with or without fibromyalgia. Methods Patients are referred to our chronic pain clinic from primary medical institutions, as we are a secondary medical institution. Although some patients have chronic pain, they have no clear organic disorder such as rheumatoid arthritis to account for the pain. Among the 367 new patients seen during the period from March 2009 to August 2012, 347 patients underwent psychiatric evaluation in face‐to‐face interviews with mental health specialists before a physical examination. Results Of the 347 patients examined, at least one psychiatric diagnosis was made for 94.6%. The average number of DSM‐IV‐TR diagnoses was 1.46 in the 330 chronic pain patients who had at least one psychiatric diagnosis. The breakdown of the number of psychodiagnoses was one in 60.8%, two in 27.1%, three in 4.9%, and more than three in 2.3% chronic pain patients with or without fibromyalgia. In fibromyalgia patients, the highest relative frequencies were found for somatoform disorders (76%), followed by dysthymic disorder (17%) and major depressive disorder (15%). In patients without fibromyalgia, the highest relative frequencies were found for somatoform disorders (64%), followed by major depressive disorder (15%) and dysthymic disorder (14%). Psychiatric disorders were found in 96.9% of fibromyalgia patients, and in 93.5% of chronic pain patients without fibromyalgia in Japan (no significant difference using chi‐square test). Conclusion Results show that chronic pain patients with or without fibromyalgia are extremely likely to be diagnosed with a psychiatric disorder.

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“…FM is a chronic pain syndrome, characterized by widespread musculoskeletal pain with diffuse tenderness in specific areas. It affects 3-6% of the world population and 80% of suffers are women [33,34]. The plasma and CSF levels of 5-HT are decreased in individuals with FM and correlate with clinical symptoms.…”

Section: Serotonin and Its Metabolites In Migrainementioning

confidence: 99%

“…As 5-HT2 and 5-HT3 are involved in pain perception, the treatment with 5-HT3 antagonist or inhibition of 5-HT reuptake is effective in FM patients [39]. The SSRI administration is necessary as depression is a common disorder among FM patients and it is present in up to 80% of individuals [34]. Participation of 5-HT in the pathogenesis of migraine attacks requires further study.…”

Section: Serotonin and Its Metabolites In Migrainementioning

confidence: 99%

Serotonin in Neurological Diseases

Dorszewska¹,

Florczak-Wyspiańska²,

Kowalska³

et al. 2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

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Serotonin (5-HT) is responsible for anxiety, aggression, and stress. Alterations in a serotonergic system play a significant role in pathogenesis of neurological diseases and neuropsychiatric disorders. A wide range of disturbances associated with serotonergic neurotransmission results from different functions of 5-HT in a nervous system. It is believed that 5-HT may be involved in the pathogenesis of migraine, epilepsy, Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), attention-deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). In these diseases, disturbances of 5-HT and its metabolites, such as 5-hydroxyindoleacetic acid (5-HIAA), were observed in the plasma, blood platelets, and cerebrospinal fluid (CSF). Changes in the level of this biogenic amine (5-HT) may be associated with malfunction of 5-HT receptors, reuptake transporter for 5-HT (5-HTT, SERT), the enzymes responsible for the synthesis and metabolism of 5-HT, and genetic variants for serotonergic system. It seems that 5-HT and its metabolites may be used as a diagnostic and prognostic marker for neurological diseases or a target for more efficient therapy in neurology in the future.

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Pain experience in Fibromyalgia Syndrome: The role of alexithymia and psychological distress

Cited by 82 publications

References 44 publications

Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome

Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome

Frequency of mental disorders among chronic pain patients with or without fibromyalgia in Japan

Serotonin in Neurological Diseases

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