Pain Fluctuations of Women with Subacute Herpetic Neuralgia During Local Methylcobalamin in Combination with Lidocaine Treatment: A Single-Blinded Randomized Controlled Trial

Xú, Gang; Tang, Wei‐Zhen; Zhou, Chaosheng; Xu, Jiake; Cheng, Ching‐Li; Gong, Wei; Dong, Shihong

doi:10.2147/jpr.s404713

Cited by 2 publications

(1 citation statement)

References 110 publications

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“…89 According to several clinical studies, the injection of methylcobalamin locally has shown promising results in treating ZAP and PHN, with an overall effectiveness rate of over 80%. [90][91][92][93][94][95] Additionally, locally injected thiamine has been found to have a significant antipruritic effect. 96 These findings suggest that a more targeted approach, focused on protecting the affected nerve, promoting nerve repair, and nourishing the damaged nerve, may be more effective than simply providing analgesia for ZAP and PHN.…”

Section: Dovepressmentioning

confidence: 99%

Low Trend for VZV-Associated Disease Patients to Visit Neurologists

Xú¹,

Xu²,

Gong³

et al. 2023

JMDH

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Background Herpes zoster (HZ) is a skin disease that can also cause virus-infectious peripheral neuropathies. Despite this, there is limited information on patient preferences for seeking medical attention for HZ and zoster-associated pain (ZAP). Our study aimed to evaluate how frequently patients with ZAP choose to visit neurologists for their symptoms. Methods This study conducted a retrospective review of electronic health records in three general hospitals from January 2017 to June 2022. Using association rule mining, the study analyzed referral behaviors. Results We identified 33,633 patients with 111,488 outpatient visits over 5.5 years. The study found that the majority of patients (74.77–91.22%) visited dermatologists during their first outpatient visit, while only a small percentage (0.86–1.47%) preferred to consult a neurologist. The proportion of patients referred to a specialist during their medical visit varied significantly between different specialties within the same hospital (p <0.05) and even within the same specialty (p<0.05). There was a weak association (Lift:1.00–1.17) of referral behaviors between dermatology and neurology. Across the three hospitals, the average number of visits to a neurologist for ZAP was 1.42–2.49, with an average electronic health record duration of 11–15 days per patient. After consulting with a neurologist, some patients were referred to other specialists. Conclusion It was observed that patients with HZ and ZAP tended to visit a variety of specialists, with only a small number seeking the assistance of neurologists. However, from the perspective of neuroprotection, it is the duty of neurologists to provide more means.

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Section: Dovepressmentioning

confidence: 99%

Low Trend for VZV-Associated Disease Patients to Visit Neurologists

Xú¹,

Xu²,

Gong³

et al. 2023

JMDH

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Deciphering pain: molecular mechanisms and neurochemical pathways–challenges and future opportunities

Dehghan,

Abolhasanzadeh,

Shademan

et al. 2024

Front. Mol. Biosci.

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This review delves into the intricate biological underpinnings of pain perception. It encompasses nociceptive signaling pathways, the molecular mechanisms involved, and the subjective experience of discomfort in humans. The initial focus is on nociceptor transduction, where specialized neurons transform noxious stimuli into electrical impulses. Subsequently, the review explores the central nervous system, elucidating how these signals are processed and modulated by critical elements such as ion channels, receptors, and neurotransmitters (e.g., substance P, glutamate, GABA). Shifting gears toward chronic pain, the review examines the concept of neuroplasticity, highlighting its potential to induce maladaptive responses through alterations in neural networks. The burgeoning field of pain genomics, alongside established genetic research, offers valuable insights that could pave the way for a framework of personalized pain management strategies. Finally, the review emphasizes the significance of these molecular insights in facilitating accurate therapeutic interventions. The overarching objective is to establish an integrative framework for precision medicine in pain management by incorporating this information alongside biopsychosocial models. This framework serves to translate the heterogeneous landscape of pain mechanisms into a coherent roadmap for the development of effective therapies.

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Pain Fluctuations of Women with Subacute Herpetic Neuralgia During Local Methylcobalamin in Combination with Lidocaine Treatment: A Single-Blinded Randomized Controlled Trial

Cited by 2 publications

References 110 publications

Low Trend for VZV-Associated Disease Patients to Visit Neurologists

Low Trend for VZV-Associated Disease Patients to Visit Neurologists

Deciphering pain: molecular mechanisms and neurochemical pathways–challenges and future opportunities

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